1 任培森, 吕文静, 丁壮, 等. 猪繁殖与呼吸综合征疫苗研制的研究进展[J]. 中国畜牧兽医, 2012, 39(7): 218~221. 2 吴国华, 赵志荀, 张强. 猪繁殖与呼吸综合征病毒分子生物学及免疫学的研究进展[J]. 安徽农业科学, 2010 (13): 6716~6719. 3 金光明, 刘胜兵, 杨倩, 等. 猪繁殖与呼吸综合征病毒疫苗不同接种途径对母猪生殖道黏膜淋巴细胞分布的影响[J]. 南京农业大学学报, 2004, 27(1): 124~126. 4 金光明, 杨倩, 王珏, 等. 猪雌性生殖道黏膜显微和超微结构观察[J]. 畜牧兽医学报, 2005, 36(6): 612~615. 5 郝亚宁, 马永平. 关于黏膜免疫佐剂的研究现状[J]. 中国微生态学杂志, 2009, 21(7): 661~663. 6 常凯凯, 姚晓英, 李大金. 女性生殖道局部黏膜免疫微环境[J]. 中国免疫学杂志, 2012, 28(12): 1142~1145. 7 崔萍, 于三科. 黏膜免疫佐剂及免疫途径研究进展[J]. 动物医学进展, 2007, 28(2): 81~84. 8 Avdic S, Cao J Z, Cheung A K L, et al. Viral interleukin-10 expressed by human cytomegalovirus during the latent phase of infection modulates latently infected myeloid cell differentiation[J]. Journal of Virology, 2011, 85(14): 7465~7471. 9 Bansal K, Elluru S R, Narayana Y, et al. PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells[J]. The Journal of Immunology, 2010, 184(7): 3495~3504. 10 Binjawadagi B, Dwivedi V, Manickam C, et al. Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS production[J]. Viral Immunology, 2011, 24(6): 475~482. 11 Brayden D J, Jepson M A, Baird A W. Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting[J]. Drug Discovery Today, 2005, 10(17): 1145~1157. 12 Charerntantanakul W, Platt R, Roth J A. Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production[J]. Viral Immunology, 2006, 19(4): 646~661. 13 Che T M, Johnson R W, Kelley K W, et al. Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus[J]. Journal of Animal Science, 2011, 89(8): 2592~2602. 14 Czerkinsky C, Holmgren J. Topical immunization strategies[J]. Mucosal Immunology, 2010, 3(6): 545~555. 15 Davis S S. Nasal vaccines[J]. Advanced Drug Delivery Reviews, 2001, 51(1): 21~42. 16 Dwivedi V, Manickam C, Patterson R, et al. Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs[J]. Vaccine, 2011a, 29(23): 4067~4076. 17 Dwivedi V, Manickam C, Patterson R, et al. Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant[J]. Vaccine, 2011b, 29(23): 4058~4066. 18 Dwivedi V, Manickam C, Binjawadagi B, et al. Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions[J]. Virol J, 2012a, 16(9): 45. 19 Dwivedi V, Manickam C, Binjawadagi B, et al. Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs[J]. PLoS One, 2012b, 7(12): e51794. 20 Foo S Y, Phipps S. Regulation of inducible BALT formation and contribution to immunity and pathology[J]. Mucosal Immunology, 2010, 3(6): 537~544. 21 Hyland K, Foss D L, Johnson C R, et al. Oral immunization induces local and distant mucosal immunity in swine[J]. Veterinary Immunology and Immunopathology, 2004, 102(3): 329~338. 22 Kimman T G, Cornelissen L A, Moormann R J, et al. Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology[J]. Vaccine, 2009, 27(28): 3704~3718. 23 Klinge K L, Vaughn E M, Roof M B, et al. Age-dependent resistance to porcine reproductive and respiratory syndrome virus replication in swine[J]. Virol J, 2009, 6(1): 177. 24 Kim D Y, Kaiser T J, Horlen K, et al. Insertion and deletion in a non-essential region of the nonstructural protein 2 (nsp2) of porcine reproductive and respiratory syndrome (PRRS) virus: Effects on virulence and immunogenicity[J]. Virus Genes, 2009, 38(1): 118~128. 25 Lemke C D, Haynes J S, Spaete R, et al. Lymphoid hyperplasia resulting in immune dysregulation is caused by porcine reproductive and respiratory syndrome virus infection in neonatal pigs[J]. The Journal of Immunology, 2004, 172(3): 1916~1925. 26 Martelli P, Gozio S, Ferrari L, et al. Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: Clinical protection and cell-mediated immunity[J]. Vaccine, 2009, 27(28): 3788~3799. 27 Moyron-Quiroz J, Rangel-Moreno J, Carragher D M, et al. The function of local lymphoid tissues in pulmonary immune responses[M].Crossroads between Innate and Adaptive Immunity, Springer US, 2007. 28 Nelson E A, Christopher-Hennings J, Benfield D A. Serum immune responses to the proteins of porcine reproductive and respiratory syndrome (PRRS) virus[J]. Journal of Veterinary Diagnostic Investigation, 1994, 6(4): 410~415. 29 Plotkin S A. Vaccines: Past, present and future[J]. Nature Medicine, 2005, 11: S5~S11. 30 Randall T D. Bronchus-associated lymphoid tissue (BALT) structure and function[J]. Advances in Immunology, 2010, 107: 187~241. 31 Renukaradhya G J, Alekseev K, Jung K, et al. Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs[J]. Viral Immunology, 2010, 23(5): 457~466. 32 Renukaradhya G J, Dwivedi V, Manickam C, et al. Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: A new perspective[J]. Animal Health Research Reviews, 2012, 13(1): 21~37. 33 Rowland R R. The stealthy nature of PRRSV infection: The dangers posed by that ever-changing mystery swine disease[J]. Vet J, 2007, 174(3): 451. 34 Sminia T, Van der Brugge-Gamelkoorn G J, Jeurissen S H. Structure and function of bronchus-associated lymphoid tissue (BALT)[J]. Critical Reviews in Immunology, 1989, 9(2): 119. 35 Suzuki H, Sekine S, Kataoka K, et al. Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells[J]. Gastroenterology, 2008, 135(3): 917~925. 36 Woodland D L, Randall T D. Anatomical features of anti-viral immunity in the respiratory tract[J]. Seminars in Immunology, 2004, 16(3): 163~70. 37 Zhang L, Tian X, Zhou F. Intranasal administration of CpG oligonucleotides induces mucosal and systemic type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo[J]. International Immunopharmacology, 2007, 7(13): 1732~1740. |