脂质代谢和糖代谢在PRRSV感染宿主细胞中作用研究进展

doi:10.16431/j.cnki.1671-7236.2024.04.036

Abstract

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) infection is known to cause reproductive disorders in sows,respiratory disease in piglets,and reduce semen quality in boars,resulting in significant economic losses to the global pig industry.PRRSV is unable to replicate on its own and relies on the host metabolic system for all stages of its life cycle.Host cells,in turn,regulate their metabolic processes to hinder PRRSV replication and maintain their normal physiological functions.Both lipid metabolism and glucose metabolism play crucial roles in PRRSV infection.As an enveloped virus,PRRSV is particularly reliant on lipid metabolism systems.Lipids are involved in various stages of the PRRSV life cycle,including adsorption,entry,replication,assembly and release,it is also associated with cellular inflammation,immunity and apoptosis.Glucose metabolism can also interfere with PRRSV life activities,thereby promoting or inhibiting PRRSV replication.The roles of fatty acids,cholesterol,phospholipids,lipid droplets and lipid rafts in lipid metabolism are reviewed,along with the involvement of glycolysis and the tricarboxylic acid cycle in glucose metabolism in PRRSV-infected host cells,so to provide a theoretical basis for elucidating the pathogenic mechanism of PRRSV and contribute to the development of vaccines and anti-PRRSV drugs.

Key words: Porcine reproductive and respiratory syndrome virus (PRRSV); host cells; lipid metabolism; glucose metabolism

CLC Number:

S852.65⁺9.6

LUO Qin, LIU Baoling, QIAO Changhong, CHEN Xiangyu, LIU Dingyu, WANG Xiaohu, WANG Gang, LIU Hao, CAI Rujian. Research Progress on the Role of Lipid Metabolism and Glucose Metabolism in PRRSV-infected Host Cells[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(4): 1686-1695.

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Research Progress on the Role of Lipid Metabolism and Glucose Metabolism in PRRSV-infected Host Cells

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