长链脂酰CoA合成酶(ACSL)的研究进展

Abstract

Abstract: Long chain acyl-CoA synthetases (ACSLs) are encoded by a multi-gene family. Synthesis of acyl-CoA catalyzed by acyl-CoA synthetase (ACS) is the first step in mammalian response to the use of fatty acids,so ACSL in fat metabolism plays a major role. In this review,we cover the nomenclature and classing of the ACSL family,the expression of ACSL gene influencing on fat metabolism,the selectivity of different ACSL family on substrate,the regulation of ACSL gene expression by different transcription factors,and the current research related to livestock ACSL. We also put forward the future research focus and research significance about the ACSL family.

Key words: ACSL; fat metabolism; gene expression; livestock

CLC Number:

Q552

LI Qing-gang, TAO Zhu, YANG Yu-zeng, ZHANG Bo, SHI Li-hua, BAN Dong-mei, ZHANG Hao. Research Progress of Long Chain Acyl-CoA Synthetase[J]. , 2012, 39(6): 137-140.

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