Abstract: 21st,with the development of human life and the level of health, the demand of green food (meat, eggs, milk) is growing, consumers are more concerned about food safety. Countries in the world, carry out the study of drug substitute for feed additives especially in Europe, Japan and other developed countries. Research and extension of green safe feed additive are encouraged and promoted actively, probiotics attract the world’s attention. But scientists still need explore the relationship between stability and continuity of such product and physiological, biochemical, nutritional aspects. Domestic and foreign scholars are working on the study of bacteriocin (antibacterid peptides or peptide antibiotics), with the progress of study and in-depth at home and abroad, people have found that these peptides not only have anti-bacterial, anti-fungal effect, but also have anti-parasite, virus, cancer and other functions, in medicine and food preservation technology, it becomes a hot research. In today’s food safety, it is possible that bacteriocin will do as a effective and safe feed additive,they need intensity and be developed, bacteriocin genetic engineering, protein engineering and molecular screening methods will continue to research and breakthroughs, it will alternant antibiotics and product green food for human finally.

Key words: lactic acid bacteria; bacteriocin; purification; Nisin