Abstract: Growth differentiation factor 9(GDF9)gene and bone morphogenetic protein 15(BMP15) gene as candidate genes on the prolificacy. Single nucleotide polymorphism of GDF9 gene and BMP15 gene was detected in Qianbei-pockmarked goats by sequencing. The results showed that there was one single nucleotide mutation (A562→C562) at exon 2 of GDF9 gene in Qianbei-pockmarked goats，and this mutation resulted in an amino acid change: glutamine→proline.The results indicated that there were two genotypes (AA and Aa ) detected in Qianbei-pockmarked goats，genotypic frequency was respectively 0.7273 and 0.2727; frequency of A and a allele was 0.8637 and 0.1363. The results showed that there was one single nucleotide mutation (C480→G480)at exon 2 of BMP15 gene in Qianbei-pockmarked goats，and this mutation resulted in an amino acid change: glutamine→glutamate. The results indicated that there were two genotypes (BB and Bb) detected in Qianbei-pockmarked goats，genotypic frequency was respectively 0.7000 and 0.3000; frequency of B and b allele were 0.8500 and 0.1500.

Key words: growth differentiation factor 9; bone morphogenetic protein 15; genetic variation; Qianbei-pockmarked goats