克隆动物的端粒长度研究进展

›› 2009, Vol. 36 ›› Issue (11): 99-104.

• 遗传繁育 • Previous Articles Next Articles

Research of Telomere Length in Cloned Animals

LV Kun, LIN Dan, HUANG Ying

(Shanghai Institution of Medical Genetics, Shanghai Jiao Tong University; Key Laboratory of Embryo Molecular Biology, Ministry of Health; Shanghai Laboratory of Embryo and Reproduction Engineering, Shanghai 200040, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-11-20 Published:2009-11-20
Contact: HUANG Ying

Abstract

Abstract: Telomeres are composed of repeated DNA sequences and specific DNA-binding proteins, which form a nucleoprotein complex at the end of eukaryotic chromosomes, and play an important role in the replication and stability of the telomeres. Recent researches indicate that telomere-shorten is closely related to disease and aging of the human. Being considered as an available instrument of agamogenesis, somatic cell nuclear transfer (SCNT) is widely applied in research and production. However, restricted by the fact that donor cells are always adult somatic cells, which contain shortened telomeres, it is significant to ensure whether telomeres of cloned animals are restored in the embryogenesis or not. In this article, authors review the latest researches about the structure of telomere, telomere maintain mechanism and telomere length of cloned mammals.

Key words: telomere; telomere length; mammal; somatic cell nuclear transfer

CLC Number:

S814.8

LV Kun;LIN Dan;HUANG Ying. Research of Telomere Length in Cloned Animals[J]. , 2009, 36(11): 99-104.

[1]	JIANG Bowen, LIU Guoshi, ZHANG Lu. Research Progress on the Primary Sex Determination Mechanisms in Mammals [J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 614-623.
[2]	YAN Yelian, ZHANG Mengya, LIU Qiuchen, WANG Xin, XU Changzhi, ZONG Yanfeng, ZHU Zhihua, WU Sucheng, SONG Yu, LI Yunsheng, ZHANG Yunhai, CAO Zubing. Research Progress of Epigenetic Reprogramming in Mammalian Somatic Cell Nuclear Transfer Embryo Development [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2259-2269.
[3]	TAO Weikun, LIU Bo, HUANG Fei, WANG Jie, GAO Qinghua. Research Progress on Xist lncRNA Mediated X Chromosome Inactivation and Its Application [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 216-223.
[4]	WANG Pengpeng, HUANG Shulin, ZHANG Yunke, WANG Zhanhui, WU Wenxue. Research Progress on Serum-free Suspension Culture of Mammalian Cells [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(3): 839-845.
[5]	QI Zicheng, LIU Zhonghua. Research Advances on OCT4 in Mammalian Early Embryonic Development [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3715-3725.
[6]	GUO Xuefeng, BAO Pengjia, CHANG Yongfang, ZHANG Yongfeng, LI Zhongbang, LEI Lei, YAN Ping, PAN Heping. Research Progress on the Development and Regulation of Mammalian Hair Follicles [J]. , 2019, 46(2): 387-394.
[7]	XU Weihua, WU Zhenfang, SHI Junsong. Research Progress on Methods to Improve Mammalian Cloning Efficiency [J]. , 2018, 45(9): 2516-2523.
[8]	HE Jing, HAI Le, Sirendalai, MING Liang, YI Li, Jirimutu. Application of Metagenomics in Mammals Gut Microbiome [J]. , 2018, 45(12): 3438-3446.
[9]	CAO Jun-guo, WEI Hai-jun, XU Bao-zeng. Research Progress on the Relationship between Cryopreservation of Mammalian Germ Cells and Their DNA Methylation [J]. , 2017, 44(3): 819-824.
[10]	XIAO Kai-li, YIN Yu-long, ZHANG Lin, DENG Bai-chuan, DENG Jin-ping, TAN Cheng-quan. Regulation Effects and Mchanism of Amino Acids on Lipid Metabolism in Mammals [J]. , 2017, 44(12): 3473-3481.
[11]	HUA Zai-dong, GUO Shuai, XIAO Hong-wei, REN Hong-yan, ZHANG Li-ping, GE Yao-wen. Effect of Oocytes in vivo and in vitro on the Developmental Potential of Porcine Somatic Cell Cloned Embryos [J]. , 2017, 44(11): 3143-3148.
[12]	FU Bo, LIU Di, MA Hong, GUO Zhen-hua, WANG Liang, LI Zhong-qiu, PENG Fu-gang, ZHANG Dong-jie, LIU Zi-guang, BAI Jing. Study on Oocyte Nuclear Factor Promotes the Early Development of Tetraploid Somatic Cell Nuclear Transfer Embryos [J]. , 2017, 44(1): 148-154.
[13]	JIA Sheng-jun, ZHAO Jiao, LI Na. Biological Functions of TLRs in Mammalian Ovulation Processes [J]. , 2016, 43(6): 1591-1596.
[14]	GUO Yuan, LIU Zong-zheng, LIU Le, MENG Fan-hua, ZHANG Yan-ru, ZHOU Huan-min, LIU Chun-xia. Production and Identification of Clone Sheep Using Bone Marrow Mesenchymal Stem Cells as Donor Cell [J]. , 2016, 43(11): 3011-3018.
[15]	SU Wen-long, LI Lu, MENG Na-na, LIU Meng-he, WANG Han-yang, LI Jie-xin, CAO Hui, TIAN Shu-jun, SUN Shu-chun, LI Jun-jie. Effects on Somatic Cell Nuclear Transfer Embryos Development of Cell Cycle Synchronization of Sheep Cumulus Cells [J]. , 2015, 42(3): 658-662.

Research of Telomere Length in Cloned Animals

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments