氨基酸对哺乳动物脂质代谢的调控及其作用机理

doi:10.16431/j.cnki.1671-7236.2017.12.012

Abstract

Abstract:

Lipid metabolism not only affects human health but also is vital to livestock and poultry production. Therefore, it is necessary to study the nutrition regulation strategy of lipid metabolism. This paper mainly introduces the four amino acids which are important for the regulation of lipid metabolism, including methionine (Met),leucine (Leu),arginine (Arg) and glutamate (Glu), and summarizes the regulation effects and mechanism on lipid metabolism of the four amino acids at the physiological level, cellular level and molecular level. This paper introduces these four amino acids in the role of nutritional research, physiological effects in animal experiments,the mechanism of regulation effect on lipid metabolism and the combination effect. Meanwhile,the regulation and mechanism of amino acid on lipid metabolism in adipose,liver and muscle tissue were emphatically discussed. This paper reviews the progress of four amino acids in basic research and livestock production application, and further analyze the potential directions in the future research on the deep mechanism of lipid metabolism to clarify the regulation effects and potential mechanism of the amino acids on mammals' lipid metabolism, which was aimed to provide a reference for the accuracy using of amino acids.

Key words: amino acids; mammals; lipid metabolism; regulation; mechanism

CLC Number:

Q493.5

XIAO Kai-li, YIN Yu-long, ZHANG Lin, DENG Bai-chuan, DENG Jin-ping, TAN Cheng-quan. Regulation Effects and Mchanism of Amino Acids on Lipid Metabolism in Mammals[J]. , 2017, 44(12): 3473-3481.

References

[1] Nair K S, Short K R. Hormonal and signaling role of branched-chain amino acids[J]. Journal of Nutrition, 2005,135(6):1547-1552.
[2] Conde-Aguilera J A,Cobo-Ortega C, Tesseraud S, et al. Changes in body composition in broilers by a sulfur amino acid deficiency during growth[J].Poultry Science,2013,92(5):1266-1275.
[3] Zhang H H,Jiang Q K,Sun W L,et al. Effects of different dietary protein levels and DL-methionine supplementation on hair growth and pelt quality in mink (Neovision vision)[J].Journal of Animal Physiology and Animal Nutrition,2013,97(6):1036-1042.
[4] 谢明,侯水生,刘福柱. 蛋氨酸毒性及其中毒机制的研究进展[J].饲料博览,2002,4:14-15.
[5] Orentreich N, Matias J R, Defelice A,et al. Low methionine ingestion by rats extends life span[J].Journal of Nutrition,1993,123(2):269-274.
[6] Zimmerman J A,Malloy V,Krajcik R, et al. Nutritional control of aging[J]. Experimental Gerontology,2003,38(1-2):47-52.
[7] Miller R A,Buehner G,Chang Y,et al. Methionine-deficient diet extends mouse lifespan,slows immune and lens aging,alters glucose,T4,IGF-Ⅰ and insulin levels, and increases hepatocyte MIF levels and stress resistance[J].Aging Cell,2005,4(3):119-125.
[8] Malloy V L,Krajcik R A, Bailey S J,et al. Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction[J].Aging Cell,2006,5(4):305-314.
[9] Sun L,Sadighi Akha A A,Miller R A,et al. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age[J]. Journals of Gerontology Series A-Biological Sciences and Medical Sciences,2009,64(7):711-722.
[10] Hasek B E,Stewart L K, Henagan T M, et al. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states[J].American Journal of Physiology-Regulatory Integrative and Comparative Physiology,2010,299(3):R728-R739.
[11] Plaisance E P, Henagan T M, Echlin H,et al. Role of beta-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction[J].American Journal of Physiology-Regulatory Integrative and Comparative Physiology,2010,299(3):R740-R750.
[12] Hasek B E,Boudreau A,Shin J,et al. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats[J].Diabetes,2013,62(10):3362-3372.
[13] Perrone C E,Mattocks D L,Hristopoulos G,et al. Methionine restriction effects on 11 beta-HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue[J].Journal of Lipid Research, 2008,49(1):12-23.
[14] Perrone C E,Mattocks D A,Jarvis-Morar M, et al. Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue,liver,and skeletal muscle of F344 rats[J]. Metabolism-Clinical and Experimental,2010,59(7):1000-1011.
[15] Plaisance E P,Greenway F L, Boudreau A,et al. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome[J].Journal of Clinical Endocrinology & Metabolism,2011,96(5):E836-E840.
[16] Zhou X H,He L Q,Wan D,et al. Methionine restriction on lipid metabolism and its possible mechanisms[J].Amino Acids,2016,48(7):1533-1540.
[17] Tomas E,Tsao T S,Saha A K,et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain:Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation[J].Proceedings of the National Academy of Sciences of the United States of America,2002,99(25):16309-16313.
[18] Yamauchi T,Kamon J,Minokoshi Y,et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase[J].Nature Medicine,2002,8(11):1288-1295.
[19] Deval C,Talvas J,Chaveroux C,et al. Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes[J]. Biochimie, 2008,90(11-12):1716-1721.
[20] Wanders D,Stone K P,Forney L A,et al. Role of GCN2-independent signaling through a noncanonical perk/nrf2 pathway in the physiological responses to dietary methionine restriction[J].Diabetes,2016,65(6):1499-1510.
[21] Stone K P,Wanders D,Orgeron M,et al. Mechanisms of Increased in vivo insulin sensitivity by dietary methionine restriction in mice[J]. Diabetes,2014,63(11):3721-3733.
[22] Lin Z F,Tian H S,Lam K S L,et al.Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice[J].Cell Metabolism,2013,17(5):779-789.
[23] Li X L,Rezaei R,Li P,et al. Composition of amino acids in feed ingredients for animal diets[J].Amino Acids,2011,40(4):1159-1168.
[24] 陈浩,毛湘冰,陈代文,等.亮氨酸调节哺乳动物脂肪代谢的研究进展[J].动物营养学报,2014,26(7):1723-1727.
[25] Zemel M B, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects[J].Nutrients,2012,4(6):529-541.
[26] Lopez N,Sanchez J,Pico C,et al. Dietary L-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus[J].Peptides,2010,31(7):1361-1367.
[27] Vianna D, Resende G F T,Torres-Leal F L,et al. Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats[J]. Nutrition,2012,28(2):182-189.
[28] Freudenberg A,Petzke K J,Klaus S. Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity[J].Amino Acids,2013,44(2):519-528.
[29] Zhang Y Y,Guo K Y,Leblanc R E,et al. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms[J].Diabetes,2007,56(6):1647-1654.
[30] 王仁华,刘晓兰,王琤韡.亮氨酸对母猪的营养作用与应用[J].饲料研究,2011,11:13-15.
[31] Duan Y H, Li F N, Li Y H, et al. The role of leucine and its metabolites in protein and energy metabolism[J].Amino Acids,2016,48(1):41-51.
[32] Chen Q,Reimer R A.Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro[J].Nutrition,2009,25(3):340-349.
[33] Sun X C,Zemel M B.Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells[J].Lipids,2007,42(4):297-305.
[34] Kozak L P,Anunciado-Koza R. UCP1:Its involvement and utility in obesity[J]. International Journal of Obesity,2008,32:S32-S38.
[35] Binder E,Bermudez-Silva F J,Elie M,et al. Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice[J].Obesity,2014,22(3):713-720.
[36] Tan B E,Li X G,Yin Y L,et al. Regulatory roles for L-arginine in reducing white adipose tissue[J].Frontiers in Bioscience-Landmark,2012,17:2237-2246.
[37] Tan B, Yin Y L, Liu Z Q, et al. Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle[J].Journal of Nutritional Biochemistry,2011,22(5):441-445.
[38] Wu G Y,Bazer F W,Davis T A,et al. Arginine metabolism and nutrition in growth,health and disease[J].Amino Acids,2009,37(1):153-168.
[39] Fu W J,Haynes T E,Kohli R,et al. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats[J].Journal of Nutrition,2005,135(4):714-721.
[40] Tan B,Yin Y L,Liu Z Q,et al. Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs[J].Amino Acids,2009,37(1):169-175.
[41] Lucotti P, Setola E, Monti L D, et al. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese,insulin-resistant type 2 diabetic patients[J].American Journal of Physiology-Endocrinology and Metabolism,2006,291(5):E906-E912.
[42] Nisoli E,Clementi E,Paolucci C,et al. Mitochondrial biogenesis in mammals:The role of endogenous nitric oxide[J].Science,2003,299(5608):896-899.
[43] Andersson K,Gaudiot N,Ribiere C,et al. A nitric oxide-mediated mechanism regulates lipolysis in human adipose tissue in vivo[J].British Journal of Pharmacology,1999,126(7):1639-1645.
[44] Fruhbeck G,Gomez-Ambrosi J. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide[J].Cell Signal,2001,13(11):827-833.
[45] Gaudiot N,Jaubert A M,Charbonnier E,et al. Modulation of white adipose tissue lipolysis by nitric oxide[J].Journal of Biological Chemistry,1998,273(22):13475-13481.
[46] Khedara A,Goto T,Morishima M,et al. Elevated body fat in rats by the dietary nitric oxide synthase inhibitor,L-N omega nitroarginine[J].Bioscience Biotechnology and Biochemistry,1999,63(4):698-702.
[47] Tan B,Yin Y L,Kong X F,et al.L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells[J].Amino Acids,2010,38(4):1227-1235.
[48] Carriere A,Carmona M C,Fernandez Y,et al. Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation——A mechanism for hypoxia-dependent effect[J]. Journal of Biological Chemistry,2004,279(39):40462-40469.
[49] Lin J,Wu H,Tarr P T,et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres[J].Nature,2002,418(6899):797-801.
[50] Miura S,Tomitsuka E,Kamei Y,et al. Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP[J].American Journal of Pathology,2006,169(4):1129-1139.
[51] Satterfield M C,Wu G. Brown adipose tissue growth and development:Significance and nutritional regulation[J].Frontiers in Bioscience-Landmark,2011,16(1):589-608.
[52] Jobgen W,Meininger C J,Jobgen S C,et al. Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats[J].Journal of Nutrition,2009,139(2):230-237.
[53] Nisoli E,Cozzi V,Carruba M O.Amino acids and mitochondrial biogenesis[J].American Journal of Cardiology,2008,101(11A):22E-25E.
[54] Long Y C,Zierath J R.AMP-activated protein kinase signaling in metabolic regulation[J]. J Clin Invest,2006,116(7):1776-1783.
[55] Kahn B B,Alquier T,Carling D,et al.AMP-activated protein kinase:Ancient energy gauge provides clues to modern understanding of metabolism[J].Cell Metabolism,2005,1(1):15-25.
[56] Lopez M,Lelliott C J,Vidal-Puig A.Hypothalamic fatty acid metabolism:A housekeeping pathway that regulates food intake[J].Bioessays,2007,29(3):248-261.
[57] Brosnan J T,Brosnan M E. Glutamate:A truly functional amino acid[J].Amino Acids,2013,45(3):413-418.
[58] Fu D Z,Yang H S,Kong X F,et al. Molecular cloning and expression profiling of excitatory amino acid carrier 1 in Huanjiang mini-piglets with different body weight[J]. Molecular Biology Report,2013,40(4):3341-3350.
[59] Feng Z M,Zhou X L,Wu F,et al. Both dietary supplementation with monosodium L-glutamate and fat modify circulating and tissue amino acid pools in growing pigs,but with little interactive effect[J].PLoS One,2014,9(1):e84533.
[60] Feng Z M,Li T J,Wu C L,et al. Monosodium L-glutamate and dietary fat exert opposite effects on the proximal and distal intestinal health in growing pigs[J].Applied Physiology Nutrition and Metabolism,2015,40(4):1-11.
[61] Feng Z M,Li T J,Wu L,et al. Monosodium L-glutamate and dietary fat differently modify the composition of the intestinal microbiota in growing pigs[J].Obesity Facts,2015,8(2):87-100.
[62] Kong X F,Zhou X L,Feng Z M,et al. Dietary supplementation with monosodium L-glutamate modifies lipid composition and gene expression related to lipid metabolism in growing pigs fed a normal-or high-fat diet[J]. Livestock Science,2015,180:247-252.
[63] He K, Du S F, Xun P C,et al. Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults:China Health and Nutrition Survey (CHNS)[J]. American Journal of Clinical Nutrition, 2011,93(6):1328-1336.
[64] Insawang T,Selmi C,Cha'on U,et al. Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population[J]. Nutrition & Metabolism,2012,9(1):1-6.
[65] Chen G,Zhang J,Zhang Y Z,et al.Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets[J]. Amino Acids,2014,46(1):245-250.
[66] Hermanussen M,Tresguerres J A. Does high glutamate intake cause obesity?[J].Journal of Pediatric Endocrinology & Metabolism Jpem,2003,16(7):965-968.
[67] Hermanussen M, Tresguerres J A. Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis[J].Journal of Perinatal Medicine,2005,31(6):489-495.
[68] Frederich R C,Löllmann B,Hamann A,et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity[J].Journal of Clinical Investigation,1995,96(3):1658.
[69] Dawson R,Pelleymounter M A,Millard W J,et al. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage[J].American Journal of Physiology,1997,273(1):E202-E206.
[70] Tang-Christensen M,Holst J J,Hartmann B,et al.The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin[J].Neuroreport,1999,10(6):1183.
[71] Shannon M,Green B,Willars G,et al. The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1(GLP-1) gut hormone and GLP-1 receptor interaction[J].Toxicology Letters,2017,265:97-105.
[72] Alwaleedi S A.Adverse effects of monosodium glutamate on serum lipid profile, cholesterol status and blood glucose in adult rats[J].Research Journal of Pharmaceutical,Biological and Chemical Sciences,2016,7(1):732-739.
[73] Egbuonu A C.Sub-chronic concomitant ingestion of L-arginine and monosodium glutamate improves feed efficiency,lipid metabolism and antioxidant capacity in male Wistar rats[J]. Pakistan Journal of Biological Sciences,2012,15(6):301-305.
[74] Hyun Y,Kim J D,Ellis M,et al. Effect of dietary leucine and lysine levels on intramuscular fat content in finishing pigs[J].Canadian Journal of Animal Science,2007,87(3):303-306.
[75] Madeira M S,Pires V M,Alfaia C M,et al. Combined effects of dietary arginine,leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs[J].British Journal of Nutrition,2014,111(9):1521-1535.
[76] Tous N,Lizardo R,Vila B,et al. Addition of arginine and leucine to low or normal protein diets:Performance,carcass characteristics and intramuscular fat of finishing pigs[J]. Spanish Journal of Agricultural Research,2016,14(4):e0605.
[77] Da Silva P M R,Zoppi C C,Filiputti E,et al. Preliminary report:Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats[J]. Metabolism-Clinical and Experimental,2010,59(6):911-913.

Regulation Effects and Mchanism of Amino Acids on Lipid Metabolism in Mammals

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	WANG Saiqiao, ZHAO Lu, ZHAI Zhenhan, ZHANG Binglei, JIA Wanhang, WANG Yuqin. Tissue Expression and Bioinformatics Analysis of miR-449a/b Precursor Sequences in Sheep [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2175-2184.
[2]	SONG Yue, SU Shengjie, ZHANG Fan, BAI Fan, DAI Lingli, WANG Na, WANG Dawei, YANG Qianwen, ZHAO Shihua, ZHANG Yuemei. Prokaryotic Expression and Polyclonal Antibody Preparation of Mannheimia haemolytica Truncated Leukotoxin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2479-2486.
[3]	LU Hui, CAI Gaofeng, WU Caihong, QIU Shulei, YUAN Chen, CHEN Xiaolan, LIU Yun, QIN Kaili. Effect of Agrocybe aegerita Polysaccharid on Immunomodulatory of Splenic Lymphocytes in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1828-1835.
[4]	ZHANG Jingyi, CHEN Li, HUANG Siyang, CHEN Xiang, LIU Zongping, TONG Xishuai. Research Progress on Pathogenic Characteristics and Pathogenicity of Ehrlichia canis [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2023-2031.
[5]	XU Chenghui, ZHANG Xumei, YANG Tong, LI Jiahui, SUN Yawei, SHI Huijun, FU Qiang, YANG Li. Molecular Mechanism of Leonurine in the Treatment of Intestinal Inflammation Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2103-2113.
[6]	CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2114-2129.
[7]	GUO Bingyu, LI Li, LI Chen, KONG Xianghui. Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1584-1592.
[8]	CHEN Shaojun, LI Gang, NAI Zida, LIU Di, JIANG Xinpeng. Research and Application of Gene-edited Probiotics in Animal Intestinal Health [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1016-1024.
[9]	DOU Jiahong, WANG Ziying, YANG Juan, ZHOU Weiwei, ZHANG Tongcun, HE Hongpeng, DAI Xiaofeng, LI Xiumei. Analysis of the Active Ingredients and Mechanism of Radix Paeoniae Rubra Antioxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1229-1240.
[10]	QIN Zhiyun, JIANG Huaizhi. An Overview of Research on Skin Hair Follicle Development and Regulatory Mechanism in Sheep During the Fetal Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 638-646.
[11]	HAN Guorui, XIAO Xiaoyue, ZHANG Yang, LI Yanhua, CHEN Xueying, WANG Xiumin, QIN Junjie, LIU Yanyan. Mechanism of Gui Qi Yimu Oral Liquid in the Treatment of Sus scrofa Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 722-733.
[12]	MENG Yingwen, LI Yuehua, SHA Zhou, LI Chenyu, GONG Youquan, DONG Yaqin, WEI Rong, ZOU Fengcai, NI Bo. Screening of the Natural Products Against Senecavirus A and Study on Its Mechanism of Antagonism [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 734-744.
[13]	WANG Wei, LI Chunzhu, WANG Shasha, SANG Rui, GE Bingjie, LI Chunting, ZHAO Xin, LIU Xinman, YU Minghong, ZHANG Xuemei. Study on the Protective Mechanism of Traditional Chinese Medicine Combined with Probiotics on Diarrhea Caused by E.coli in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 779-788.
[14]	LIU Lin, WU Baoqing, GUO Xiaoyin, YU Wenhui, TIAN Lang. Study on Bacteriostatic Action of Aqueous Extract of Granati pericarpium Against Multi-drug Resistant Escherichia coli of Swine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 328-340.
[15]	LIU Hongying, WANG Jingyu, CUI Zhenzhen, MA Qingxia, WANG Tingting, LI Jianming, SHI Kun, GONG Qinglong, DU Rui, LENG Xue. Research Progress on Immune Adjuvant Effect and Related Mechanism of Active Ingredients of Traditional Chinese Medicine on Animal Vaccines [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 390-397.