哺乳动物初级性别决定机制研究进展

doi:10.16431/j.cnki.1671-7236.2024.02.018

Abstract

Abstract: Sex determination in mammals is an important event that occurs during early embryonic development, and is crucial for the formation of an animal's reproductive capability.In recent years, with the development of high-throughput sequencing techniques, the transcriptome, proteome and spatial transcriptome analyze methods at the single-cell level and the cell lineage tracking and precise gene manipulation methods have made a great progress.All these techniques enabled the investigation of sex determination and gonadal development of mammals have made remarkable progress.Meanwhile, along with the continuous increase in the demand for sex-specific animals in livestock and poultry breeding, a series of breakthroughs have been made in the development of new sex sorting technologies based on sex determination mechanisms.With the elevated requirements of animal welfare, the application of postnatal sex sorting methods is limited, the sex sorting methods at sex determination stage shows great potential for application in the field of livestock and poultry production.The authors summarize the regulatory network of sex determination in mammals by analyzing the classical experiments related to sex determination and combining with the case reports of genetic defects clinical cases, and the entire regulatory network of mammalian primary gender determination is connected by studying the gender reversal phenomenon and gender specific differentiation process in gene expression manipulation experiments related to gender determination.In addition, this article traces the progress and development trend of sex sorting technologies utilizing gene editing techniques based on sex determination mechanisms.Thus, the review of mammalian sex determination mechanism in recent years will provide theoretical references for the innovative of livestock sex sorting technologies.

Key words: mammals; sex determination; molecular regulatory network; sex control

CLC Number:

S814

JIANG Bowen, LIU Guoshi, ZHANG Lu. Research Progress on the Primary Sex Determination Mechanisms in Mammals[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 614-623.

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Research Progress on the Primary Sex Determination Mechanisms in Mammals

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