宏基因组学在哺乳动物肠道微生物中的应用

doi:10.16431/j.cnki.1671-7236.2018.12.016

Abstract

Abstract:

There are a large number of microorganisms that inhabit in the gut of mammals animal.The gut microbiome are closely related to host digestion,absorption and immunization.The metagenomics of intestinal microbiota has received significant attention from researchers.With the application of molecular biologic technology in the field of the intestinal microbiome,especially metagenomic sequencing of the next-generation sequencing technology,progress has been made in the study of the intestinal microbiome.Metagenomics can be used to study intestinal microbiome diversity and its relationship to health and disease.Moreover,functional metagenomics can identify novel functional genes,and determine interactions and co-evolution between microbiota and host.This review will introduce the recent advances and successful application in mammalian gastrointestinal microbes and the limitations of metagenomics,and the prospects of their application in the researches of gut microbiota were discussed,so as to further understanding the importance of intestinal microbiota in intestinal function of mammals.

Key words: metagenomics; intestinal microbiome; mammals

CLC Number:

HE Jing, HAI Le, Sirendalai, MING Liang, YI Li, Jirimutu. Application of Metagenomics in Mammals Gut Microbiome[J]. , 2018, 45(12): 3438-3446.

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Application of Metagenomics in Mammals Gut Microbiome

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