全基因组重测序在畜禽研究领域的应用进展

doi:10.16431/j.cnki.1671-7236.2023.10.026

Abstract

Abstract: Whole genome resequencing (WGRS) is the whole genome level sequencing between different individuals of species with known reference genome sequences,which has the advantages of abundant detection variant types,high cost performance and wide application.With the reduction of sequencing cost and the completion of animal genome sequencing,WGRS technology has become an important tool for the research of genetic variation in animals.The large amount of genetic variation information obtained through WGRS,including single nucleotide polymorphism (SNP),insertion/deletion (InDel),structural variation (SV) and copy number variation (CNV),etc.,enriches the existing genome sequence.The resulting large-scale dataset of WGRS provides a genomic information base for exploring phenotypic traits and genetic improvement in animals,and promotes the in-depth study and utilization of the genetic resources.In this article,the condition of WGRS technology and its key influencing factors (sequencing depth,sequence comparison and variant detection) were summarized,the application progress on this technology in the research field of important farm animals (cattle,sheep,pigs and chickens) was reviewed,and the future research trend focusing on integrated analysis of resequencing data,accurate phenotypic records and multi-omics information was prospected.

Key words: whole genome resequencing; farm animals; genetic diversity; selection and evolution; functional gene

CLC Number:

S813.3

YE Wen, SUN Dongxiao, HAN Bo. Application Progress on Whole Genome Resequencing in Farm Animals[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(10): 4125-4132.

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Application Progress on Whole Genome Resequencing in Farm Animals

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