Abstract: 【Objective】 The purpose of this experiment was to study the anti-inflammatory,analgesic and antipyretic effects of Erding extract powder.【Method】 The anti-inflammatory,analgesic and antipyretic effects of Erding extract powder were studied by xylene induced auricle swelling,glacial acetic acid induced body twisting in mice and lipopolysaccharide (LPS) induced fever in rabbits.The experimental mice were randomly divided into 5 groups,10 mice in each group,which were low,medium and high dose groups of Erding extract powder,positive control group (Pudilan group/aspirin group) and model control group.Erding extract powder low,medium and high dose groups and Pudilan group were given intragastric administration of 3.9,7.8,15.6 and 4.8 g/kg crude drug,respectively,once a day for 4 consecutive days.Aspirin group was given intragastric administration of 0.2 g/kg aspirin on the fourth day,and model control group was given an equal amount of purified water.After administration,specific operations were performed according to different experiments.Rabbits were injected with 0.3 mL/kg LPS solution (2 μg/mL) through ear vein to establish LPS thermogenic model,which were randomly divided into 5 groups,including low,medium and high dose groups of Erding extract powder,and aspirin group were administrated intragastric at doses containing crude drug 1.4,2.8,5.6 and 0.1 g/kg,respectively.The model control group was given an equal amount of purified water,and the changes of rabbit body temperature were measured at 1,2,3,4,5 and 6 h after administration.【Result】 The results of auricle swelling induced by xylene in mice showed that,compared with model control group,auricle swelling of mice in high and medium dose groups of Erding extract powder were extremely significantly or significantly decreased (P<0.01 or P<0.05).Compared with Pudilan group,there was no significant difference in each dose group of Erding extract powder (P>0.05).The writhing test of mice induced by glacial acetic acid showed that compared with model control group,the body writhing of mice in high and medium dose groups of Erding extract powder were extremely significantly or significantly decreased (P<0.01 or P<0.05).Compared with aspirin group,there was no significant difference of the body writhing of mice in Erding extract powder high dose group (P>0.05),but significant or extremely significant difference between medium and low dose groups (P<0.05 or P<0.01).The results of LPS fever test showed that compared with model control group,2 h after administration,the body temperature of rabbits in aspirin group and Erding extract powder high and medium dose groups were extremely significantly or significantly decreased (P<0.01 or P<0.05).Compared with aspirin group,2 h after administration, the body temperature of rabbits in Erding extract powder medium dose group was significant increased (P ＜0.05).【Conclusion】 The results showed that Erding extract powder had good anti-inflammatory,analgesic and antipyretic effects,which provide theoretical basis for clinical application and further research of Erding extract powder.

Key words: Erding extract powder; anti-inflammatory; analgesic; antipyretic