乳腺康注射液的药效学研究

doi:10.16431/j.cnki.1671-7236.2017.09.039

Abstract

Abstract:

The study was aimed to investigate the in vitro and in vivo efficacy of Ruxiankang injection.The Oxford cup method was took to study the antibacterial activity in vitro of Ruxiankang injection;Six classical pharmacological models which were hot plate method, acetic acid inducing writhing, xylene inducing ear edema,egg white inducing paw edema, fever in rats induced by 2,4-dinitrophenol and dried yeast were adopted to study the analgesic, anti-inflammatory and antipyretic effects of Ruxiankang injection.The results showed that Ruxiankang injection had significant inhibitory effect in vitro on Escherichia coli and Staphylococcus aureus; And among them, middle and high dose groups could extremely significantly increase the pain threshold of mice and reduce the writhing times of mice (P<0.01);Middle dose group could significantly reduce the degree of ear swelling induced by xylene and foot metatarsus swelling by egg white in mice (P<0.05);Middle and high dose groups had significant antipyretic effect caused by 2, 4-dinitrophenol fever at 1.5 to 2.0 and 3.0 to 3.5 h and dry yeast at 1.0 to 3.5 h (P<0.05).The results indicated that Ruxiankang injection could obviously inhibit Escherichia coli and Staphylococcus aureus activity and had remarkable antipyretic analgesic and anti-inflammatory effects.

Key words: Ruxiankang injection; Staphylococcus aureus; antiinflammatory; analgesia; antipyretic

CLC Number:

R285.5

LIU Tao, PENG Xiao-feng, LIU Cui, PAN Chun-hui, YANG Dan, ZHANG Wen-jing, DENG Yan-jun, XU Yu-ling. Study on the Pharmacodynamics of Ruxiankang Injection[J]. , 2017, 44(9): 2822-2828.

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Study on the Pharmacodynamics of Ruxiankang Injection

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