共轭亚油酸的生物学功能及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2019.11.010

Abstract

Abstract: As a natural new functional fatty acid,conjugated linoleic acid (CLA) has anti-hypertensive,anti-cancer,anti-diabetic and other biological properties,and its main active isomers play different roles.In recent years,with the decrease of CLA artificial synthesis cost and the deep researches in the field of animal nutrition,it was found that CLA can inhibit the expression and production of pro-inflammatory factors,promote the production of anti-inflammatory factors,and achieve anti-inflammatory effects,it can also regulate lymphocyte proliferation and differentiation,macrophage activity,promote antibody synthesis,regulate humoral immunity and cellular immunity,thereby enhancing animal immunity.CLA can also regulate the expression of a variety of nuclear transcription factors,affect fatty acid uptake and oxidation,as well as lipid anabolism,thereby reducing body fat deposition,increasing intramuscular fat content,changing fatty acid composition,and improving meat quality.Therefore,CLA has potential application value and broad market prospects in animal husbandry production.The article mainly introduced the roles of CLA in anti-inflammatory,immune function,lipid metabolism and anti-oxidation,and reviewed the biological functions of CLA and its application researches in animal production.In addition,CLA was also discussed as a feed additive,including its synthetic purity,optimal addition amount in different types of animals,different ages,feeding methods,in order to provide a theoretical reference for its rational application in animal production.

Key words: conjugated linoleic acid(CLA); anti-inflammatory; immune regulation; lipid metabolism; anti-oxidation

CLC Number:

S816.7

YANG Mei, MA Jie, YANG Tai, YAN Zhaoming, CHEN Qinghua. Biological Function of Conjugated Linoleic Acid and Its Application in Animal Production[J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(11): 3216-3224.

References

[1] ROSA R,ANDRADE A M,BANDARRA N M,et al.Physiological and biochemical effects of conjugated linoleic acid and its use in aquaculture[J].Reviews in Aquaculture,2010,2(2):59-72.
[2] KIM K J,LEE J,PARK Y,et al.ATF3 mediates anti-cancer activity of trans-10,cis-12-conjugated linoleic acid in human colon cancer cells[J].Biomolecules & Therapeutics,2015,23(2):134-140.
[3] BRUEN R,FITZSIMONS S,BELTON O.Theroprotective effects of conjugated linoleic acid[J].British Journal of Clinical Pharmacology,2017,83(1):46-53.
[4] HERRERA-MEZA M S,MENDOZA-LóPEZ M R,GARCíA-BARRADAS O,et al.Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats[J].International Journal of Food Sciences and Nutrition,2013,64(5):575-586.
[5] SONG K,SONG I B,GU H J,et al.Anti-diabetic effect of fermented milk containing conjugated linoleic acid on type Ⅱ diabetes mellitus[J].Korean Journal for Food Science of Animal Resources,2016,36(2):170-177.
[6] BESSA R J B,SANTOS-SILVA J,RIBEIRO J M R,et al.Reticulo-rumen biohydrogenation and the enrichment of ruminant edible products with linoleic acid conjugated isomers[J].Livestock Production Science,2000,63(3):201-211.
[7] GRIINARI J M,CORL B A,LACY S H,et al.Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase[J].Journal of Nutrition,2000,130(9):2285-2291.
[8] 张可,滕域晰,胡凯,等.共轭亚油酸合成原料的研究进展[J].中国粮油学报,2018,33(3):140-146. ZHANG K,TENG Y X,HU K,et al.Research progress of feedstock for conjugated linoleic acid[J].Journal of the Chinese Cereals and Oils Association,2018,33(3):140-146.(in Chinese)
[9] SHOKRYZADAN P,RAJION M A,MENG G Y,et al.Conjugated linoleic acid:A potent fatty acid linked to animal and human health[J]. Critical Reviews in Food Technology,2017,57(13):12.
[10] DESREUMAUX P,DUBUQUOY L,NUTTEN S,et al.Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer.A basis for new therapeutic strategies[J].Journal of Experimental Medicine,2001,193(7):827-838.
[11] HUANG W C,TU R S,CHEN Y L,et al.Conjugated linoleic acids suppress inflammatory response and ICAM-1 expression through inhibition of NF-κB and MAPK signaling in human bronchial epithelial cells[J].Food & Function,2016,7(4):2025-2033.
[12] HUEBNER S M,OLSON J M,CAMPBELL J P,et al.Low dietary c9t11-conjugated linoleic acid intake from dairy fat or supplements reduces inflammation in collagen-induced arthritis[J].Lipids,2016,51(7):807-819.
[13] KONG L,CHENG S,XIANG X,et al.Dietary conjugated linoleic acid modulates morphology,selective immune parameters,and gene expressions in the intestine of grass carp[J].Fish and Shellfish Immunology,2018,86:536-548.
[14] ERIK-OLIVER G,DANIEL K,KAAN B,et al.Inflammatory bowel disease and mutations affecting the interleukin-10 receptor[J].New England Journal of Medicine,2009,361(21):2033-2045.
[15] LI G,BARNES D,BUIZ D,et al.10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo[J].Journal of Lipid Research,2005,46(10):2134-2142.
[16] SHEU J N,LIN T H,LII C K,et al.Contribution of conjugated linoleic acid to the suppression of inducible nitric oxide synthase expression and transcription factor activation in stimulated mouse mesangial cells[J].Food & Chemical Toxicology,2006,44(3):409-416.
[17] VILADOMIU M,HONTECILLAS R,BASSAGANYA-RIERA J.Modulation of inflammation and immunity by dietary conjugated linoleic acid[J].European Journal of Pharmacology,2016,785(15):87-95.
[18] MARIANNE O,JOSEP B R,MOHEDE I C M.Immunomodulatory properties of conjugated linoleic acid[J].American Journal of Clinical Nutrition,2004,79(6 Suppl):1199-1206.
[19] LIU Y X,ZHU K Y,LIU Y L,et al.Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection[J].Animal,2016,10(10):1660-1665.
[20] RAMÍREZ-SANTANA C,CASTELLOTE C,CASTELL M,et al.Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life[J].Journal of Nutritional Biochemistry,2011,22(5):495-501.
[21] CHANGHUA L,JINDONG Y,DEFA L,et al.Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide[J].Journal of Nutrition,2005,135(2):239-244.
[22] KANG J H,LEE G S,JEUNG E N B,et al.Trans-10,cis-12-conjugated linoleic acid increases phagocytosis of porcine peripheral blood polymorphonuclear cells in vitro[J].British Journal of Nutrition,2007,97(1):117-125.
[23] SOCHA B M,ŁUPICKA M,SZCZEPAŃSKA A A,et al.PPAR expression throughout the oestrous cycle in the bovine endometrium[J].Theriogenology,2017,100:88-94.
[24] WANG Y M,NAGAO K,INDUE N,et al.Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats[J].Bioscience Biotechnology & Biochemistry,2006,70(2):355-362.
[25] QI X,WU S,ZHANG H,et al.Effects of dietary conjugated linoleic acids on lipid metabolism and antioxidant capacity in laying hens[J].Archives of Animal Nutrition,2011,65(5):354-365.
[26] 张天颖.反10、顺12共轭亚油酸(trans10,cis12-CLA)对奶山羊乳腺上皮细胞脂代谢的调控作用研究[D].杨凌:西北农林科技大学,2018. ZHANG T Y.Regulation mechanism of trans 10,cis 12 conjugated linoleic acid (t10c12-cla) in lipid metabolism of mammary epithelial cells on dairy goat[D].Yangling:Northwest A & F University,2018.(in Chinese)
[27] TAO H,CHANG G,XU T,et al.Feeding a high concentrate diet down-regulates expression of ACACA,LPL and SCD and modifies milk composition in lactating goats[J].PLoS One,2015,10(6):e130525.
[28] PETERSON D G,MATITASHVILI E A,BAUMAN D E.The inhibitory effect of trans-10,cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1[J].Journal of Nutrition,2004,134(10):2523-2527.
[29] MA L,LENGI A J,MCGILLIARD M L,et al.Short communication:Effect of trans-10,cis-12 conjugated linoleic acid on activation of lipogenic transcription factors in bovine mammary epithelial cells[J].Journal of Dairy Science,2014,97(8):5001-5006.
[30] BROCARDO P S,BOEHME F,PATTEN A,et al.Anxiety-and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders:Protective effects of voluntary physical exercise[J].Neuropharmacology,2012,62(4):1607-1618.
[31] HUANG Y S,LIN Z D,RONG H,et al.Effects of conjugated linoleic acid on growth body composition,antioxidant status,lipid metabolism and immunity parameters of juvenile Chu's croaker,Nibea coibor[J].Aquaculture Research,2017,49(1):6447-6455.
[32] ZUO R T,AI Q H,MAI K S,et al.Effects of conjugated linoleic acid on growth,non-specific immunity,antioxidant capacity,lipid deposition and related gene expression in juvenile Large Yellow croaker (Larmichthys crocea) fed soybean oil-based diets[J].British Journal of Nutrition,2013,110(07):1220-1232.
[33] BERGAMO P,MAURANO F,ROSSI M.Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress[J].Free Radical Biology & Medicine,2007,43(1):71-79.
[34] FUKE G,NORNBERG J L.Systematic evaluation on the effectiveness of conjugated linoleic acid in human health[J].Critical Reviews in Food Technology,2016,57(1):1-7.
[35] LEE K W,LEE H J,CHO H Y,et al.Role of the conjugated linoleic acid in the prevention of cancer[J].Critical Reviews in Food Science & Nutrition,2005,45(2):135-144.
[36] SHAHZAD M M K,FELDER M,LUDWIG K,et al.Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress,autophagy,and modulation of SRC[J].PLoS One,2018,13(1):e189524.
[37] PARK H S,CHO H Y,HA Y L,et al.Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats[J].Journal of Nutritional Biochemistry,2004,15:229-235.
[38] CHO H J,KIM W K,KIM E J,et al.Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2003,284(6):996.
[39] WAN X Z,YUAN X L,YANG X L,et al.Studies on mechanism of cis9,trans11-CLA and trans10,cis12-CLA inducing apoptosis of human breast cancer cell line MCF-7[J].The Chinese-German Journal of Clinical Oncology,2010,9(10):583-589.
[40] KANTER J,GOODSPEED L,WANG S,et al.10,12 conjugated linoleic acid-driven weight loss is protective against atherosclerosis in mice and is associated with alternative macrophage enrichment in perivascular adipose tissue[J].Nutrients,2018,1416:1-14.
[41] SARAH M C,CLARE C,ROISIN O,et al.Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell[J].Atherosclerosis,2010,211(1):96-102.
[42] COPPINGER J A,GERARD C,SINEAD T,et al.Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions[J].Blood,2004,103(6):2096-2104.
[43] TORRESDUARTE A P,VANDERHOEK J Y.Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets[J].Biochimica Et Biophysica Acta Molecular Cell Research,2003,1640(1):69-76.
[44] 王生辉.共轭亚油酸对开产蛋鸡生产性能、蛋品质、蛋黄脂质组成和胆固醇代谢的影响[D].兰州:甘肃农业大学,2018. WANG S H.Effects of conjugated linoleic acid on performance,egg quality,fatty acid profile of egg yolk and cholesterol metabolism in primiparous laying hens[D].Lanzhou:Gansu Agricultural University,2018.(in Chinese)
[45] 郗艳菊.共轭亚油酸对肉鸡肌肉品质、脂类代谢和免疫机能影响的研究[D].保定:河北农业大学,2009. XI Y J.Effect of dietary conjugated linoleic acid on carcass characteristics,lipids metabolism and immune performance of broilers[D].Baoding:Hebei Agricultural University,2009.(in Chinese)
[46] LONG F Y,YANG X,GUO Y M,et al.Conjugated linoleic acids alleviate the immunosuppression of peripheral blood T lymphocytes in broiler chickens exposed to cyclosporin A[J].Poultry Science,2012,91(10):2431.
[47] ZHANG H J,GUO Y M,YUAN J M.Conjugated linoleic acid enhanced the immune function in broiler chicks[J].British Journal of Nutrition,2005,94(5):746-752.
[48] 刘永祥,刘艳丽,姜东风,等.共轭亚油酸和鱼油组合对雄性肉鸡屠体性状、肌肉脂肪酸组成和脂质过氧化状态的影响[J].动物营养学报,2015,27(8):2517-2526. LIU Y X,LIU Y L,JIANG D F,et al.Combination effects of conjugated linoleic acid and fish oil on carcass traits,fatty acid composition and lipid peroxidation status of muscles of male broiler chickens[J].Chinese Journal of Animal Nutrition,2015,27(8):2517-2526.(in Chinese)
[49] WEN J,SHAOPING N,ZHE Q,et al.The effects of conjugated linoleic acid on growth performance,carcass traits,meat quality,antioxidant capacity,and fatty acid composition of broilers fed corn dried distillers grains with solubles[J].Poultry Science,2014,93(5):1202-1210.
[50] CORINO C,PASTORELLI G,ROSI F,et al.Effect of dietary conjugated linoleic acid supplementation in sows on performance and immunoglobulin concentration in piglets[J].Journal of Animal Science,2009,87(7):2299-2305.
[51] 邹书通,蒋宗勇,林映才.共轭亚油酸对14日龄断奶仔猪部分免疫指标的影响[J].动物营养学报,2006,18(1):6-11. ZOU S T,JIANG Z Y,LIN Y C.Effect of conjugated linoleic acid on some immune indices in 14-day weaned piglets[J]. Chinese Journal of Animal Nutrition,2006,18(1):6-11.(in Chinese)
[52] HUANG J X,QI R L,CHEN X L,et al.Improvement in the carcass traits and meat quality of growing-finishing Rongchang pigs by conjugated linoleic acid through altered gene expression of muscle fiber types[J].Genetics & Molecular Research,2014,13(3):7061-7069.
[53] TEIXEIRA S,CHAVEIRO A,MOREIRA DA SLISA F.Effect of conjugated linoleic acid on boar semen quality after long-term refrigeration at 17℃[J].Reproduction in Domestic Animals,2015,50(4):604-610.
[54] 贾宝瑜.共轭亚油酸对猪卵母细胞体外成熟、胚胎培养和冷冻保存的作用机制[D].北京:中国农业大学,2014. JIA B Y.Effects of t10c12 CLA on oocyte in vitro maturation,embryo development and cryopreservation in pig[D].Beijing:China Agricultural University,2014.(in Chinese)
[55] KRAMER R,WOLF S,PETRI T,et al.A commonly used rumen-protected conjugated linoleic acid supplement marginally affects fatty acid distribution of body tissues and gene expression of mammary gland in heifers during early lactation[J].Lipids in Health & Disease,2013,12(1):96-108.
[56] KANIKARLA-MARIE P,JAIN S K.Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes[J].Free Radical Biology and Medicine,2016,95:268-277.
[57] OLIVEIRA R C,PRALLE R S,RESENDE L C D,et al.Prepartum supplementation of conjugated linoleic acids (CLA) increased milk energy output and decreased serum fatty acids and β-hydroxybutyrate in early lactation dairy cows[J].PLoS One,2018,13(5):e197733.
[58] 罗军,单翠燕,王海滨,等.共轭亚油酸对奶山羊公羔肉用性能以及肌肉和脂肪中脂肪酸组成的影响[J].动物营养学报,2010,22(3):709-716. LUO J,SHAN C Y,WANG H B,et al.Effects of dietary conjugated linoleic acids on meat performance and fatty acid composition in muscle and fat tissues in male kids of Guanzhong diary goats[J].Journal of Animal Nutrition,2010,22(3):709-716.(in Chinese)
[59] SCHIAVON S,BERGAMASCHI M,PELLATTIERO E,et al.Fatty acid composition of lamb liver,muscle,and adipose tissues in response to rumen-protected conjugated linoleic acid (CLA) supplementation is tissue dependent[J].Journal of Agricultural and Food Chemistry,2017,65(48):10604-10614.
[60] ZHANG H,DONG X,WANG Z,et al.Dietary conjugated linoleic acids increase intramuscular fat deposition and decrease subcutaneous fat deposition in Yellow Breed×Simmental cattle[J].Animal Science Journal,2016,87(4):517-524.
[61] 周玉香,杨宇为.过瘤胃赖氨酸、共轭亚油酸和N-氨甲酰谷氨酸对舍饲滩羊产肉性能和肉品质的影响[J].动物营养学报,2015,27(12):3904-3911. ZHOU Y X,YANG Y W.Effects of rumen-protected,conjugated linoleic acid and N-carbamoyl glutamic acid on meat performance and meat quality of stabling Tan sheep[J].Chinese Journal of Animal Nutrition,2015,27(12):3904-3911.(in Chinese)
[62] 戴四发,闻爱友,王立克,等.肉仔鸡肌肉色泽与品质相关性研究[J].中国农业大学学报,2007,12(1):61-64. DAI S F,WEN A Y,WANG L K,et al.Study on relationship between meat color and meat quality of Arber Acres broiler[J].Journal of China Agricultural University,2007,12(1):61-64.(in Chinese)

Biological Function of Conjugated Linoleic Acid and Its Application in Animal Production

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