草食动物免疫球蛋白表达谱及其多样性机制研究进展

doi:10.16431/j.cnki.1671-7236.2023.08.029

Abstract

Abstract: The research on disease resistance breeding of herbivores is shifting from traditional breeding to molecular level.The antibodies in the immune system of herbivores have a very unique structure and diversity generation mechanism,and the rich antibody library is an important basis for the formation of disease resistance of herbivores.Antibody is composed of immunoglobulin,which has heavy chain and light chain,and the structure and diversity mechanism of immunoglobulin are different among herbivores.Although the number of immunoglobulin genes in herbivores is limited,the diverse mechanisms in various forms contribute to the formation of rich antibody libraries,which further enhance the immune capacity of animals.At present,the case fatality rate of herbivores in farms is relatively high,and the improvement of their immune levels is urgent.Therefore,it is very important to study the structure and diversity mechanism of their immunoglobulin.The author introduces the basic structure and different types of immunoglobulin,and briefly describe the gene structure and expression diversity mechanism of immunoglobulin in four herbivores:Cattle,sheep,rabbit and camel,in order to provide relevant theoretical basis and research ideas for the breeding of disease resistance.

Key words: herbivore; immunoglobulin; expression profile; expression mechanism; nano antibodies

CLC Number:

S852.4

LEI Yichen, WANG Ziteng, JIANG Junyi, WANG Shuhui, SUN Xiuzhu. Advances on Expression Profile and Diversity Mechanisms of Immunoglobulins in Herbivore[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(8): 3313-3324.

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Advances on Expression Profile and Diversity Mechanisms of Immunoglobulins in Herbivore

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