Abstract: Glyphosate is an organophosphorus herbicide, which is widely used due to its low cost, strong systemic conductivity, and broad herbicidal spectrum.The extensive use of glyphosate not only destroys the ecosystem, but also accumulates in animals through bioaccumulation and spreads along the food chain, producing toxic effects on non-target organisms.Combined with domestic and foreign research progress, the authors overviewed the action mechanism, use and pollution status of glyphosate, and analyzed the toxic effects of glyphosate abuse on non-target organisms.The toxic effects of glyphosate on aquatic, terrestrial and amphibian animals were mainly discussed, such as neurotoxicity, oxidative toxicity, reproductive toxicity, genotoxicity, teratogenicity and carcinogenicity.In addition, the authors further summarized the main toxicological mechanisms of glyphosate toxicity in animals (such as causing oxidative stress, promoting cell apoptosis, damaging nerve conduction), initially put forward the key issues that need to be solved in this research field, and looked forward to the reasonable use of glyphosate and related research on animal toxicity in the future.The purpose of this paper was to provide reference basis for the in-depth study of glyphosate toxicity in animals and the environmental risk assessment in its use.

Key words: glyphosate; aquatic animals; terrestrial animals; amphibians; toxicity