头孢喹肟在猪呼吸道感染中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2019.04.032

Abstract

Abstract:

Respiratory disease seriously threats the livestock industry,which has caused high morbidity and mortality so that resulted in huge economic losses.Actinobacillus pleuropneumoniae (A.pleuropneumoniae),Pasteurella multocida (P.multocida),Streptococcus suis (S.suis) and Haemophilus parasuis (H.parasuis) are the material reasons for the respiratory tract diseases which caused by the bacterial infected.Cefquinome,the fourth generation of cephalosporins soly for animals,which is characterized as quick absorption,high bioavailability,high stability to β-lactamases and low toxicity to mammals.It can effectively treat porcine respiratory diseases and prevent resistance.The article described the physicochemical properties,bactericidal mechanism and pharmacokinetics of cefquinome,and compared the pharmaceutical parameters of cefquinome in different animals,indicating that cefquinome had a short peak time and high peak concentration in pigs,elimination half-life was longer,could quickly exert high-efficiency antibacterial effect and maintain antibacterial effect for a certain period of time.The in vitro antibacterial activity and clinical treatment effect of cefquinome on the main pathogens of respiratory tract in pigs were systematically introduced.It was found that the clinical pathogens of respiratory tract had high sensitivity to cefquinome and had a promising clinical application.However,there are some problems in the clinical application of this drug.The unreasonable use of cefquinome leads to the emergence of drug resistance.Through the research of PK-PD synchronization model and the establishment of drug resistance determination criteria,it can provide a scientific basis for the rational application of the drug.

Key words: respiratory disease; Actinobacillus pleuropneumoniae; Pasteurella multocida; Streptococcus suis; Haemophilus parasuis; cefquinome

CLC Number:

S859.79⁺6

MI Kun, HUANG Lingli. Advances in the Application of Cefquinome in Respiratory Tract Infection of Pigs[J]. , 2019, 46(4): 1227-1235.

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Advances in the Application of Cefquinome in Respiratory Tract Infection of Pigs

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