转录组测序技术在猪繁殖与呼吸综合征病毒研究中的应用

doi:10.16431/j.cnki.1671-7236.2019.01.005

Abstract

Abstract:

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of reproductive failure in sows and respiratory disorders in piglets.The spread and outbreak of PRRSV has led to a serious threat to global pig industry.Currently,the pathogenic mechanism and interaction with the hosts of PRRSV remains unclear.With the rapid development of high throughput sequencing,the transcriptome sequencing has been widely applied in the research of PRRSV.It offers a new way for the explanation of the pathogenic mechanism and interaction with the hosts of PRRSV.This article reviews the application of transcriptome sequencing technology in the response,the function of virus proteins,the strains,the vaccine and the resistance breeding of PRRSV research,it summarizes the differentially expressed genes (DEGs) and pathways enriched in the transcriptome sequencing of PRRSV infection,and may provide a reference for PRRSV research in the future.

Key words: porcine reproductive and respiratory syndrome virus (PRRSV); transcriptome sequencing technology; differentially expressed genes; pathways

CLC Number:

S852.4

LIANG Wan, ZHOU Danna, PENG Zhong, YANG Keli, DUAN Zhengying, GUO Rui, LIU Wei, WU Bin, CHEN Wenjie, MENG Li, TIAN Yongxiang. Application of Transcriptome Sequencing Technology in Porcine Reproductive and Respiratory Syndrome Virus Research[J]. , 2019, 46(1): 37-44.

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Application of Transcriptome Sequencing Technology in Porcine Reproductive and Respiratory Syndrome Virus Research

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