中药与抗菌药物联用对猪源大肠杆菌耐药性的抑制作用

doi:10.16431/j.cnki.1671-7236.2018.09.036

Abstract

Abstract:

This study was aimed to discuss the effect of drug resistance of Escherichia coli(E.coli) by combining traditional Chinese medicine and antibiotics drugs.50 samples which collected from Henan province were isolated for identification,biochemical experiments and pathogenicity test.12 kinds of traditional Chinese medicine were selected for isolation and identification of pathogenic porcine E.coli,and the K-B method was used to detect the drug resistance.The screened traditional Chinese medicines and antibiotics were used to conduct in vitro antibacterial tests against pathogenic E.coli,and analyze the inhibitory effect of Chinese and Western drugs on E.coli.The results showed that 23 strains of 50 samples were consistent with the isolation and culture characteristics and biochemical characteristics of E.coli.23 strains of bacteria were pathogenic Escherichia coli.Through the drug resistance test,23 test strains had different degrees of resistance to the tested traditional Chinese medicines.The resistance rate of the tested strains to licorice was the highest (82.6%),followed by the birthplace (78.2%),and the resistance to cork(17.3%) and pulsatilla (21.7%) were lower,with certain sensitivity.In vitro antibacterial result showed that the combination of traditional Chinese medicine and antibiotics had different degrees of antibacterial effect,and the antibacterial effect of cork,pulsatilla chinensis combined with antibiotics was the most obvious.It showed that the combination of traditional Chinese medicine and antibiotics could not only inhibit the drug resistance of E.coli,but also delay the emergence of drug resistance of E.coli.

Key words: traditional Chinese medicine; antibacterial drugs; Escherichia coli; drug resistance; inhibitory effect

CLC Number:

S852.61⁺2

ZHANG Bingliang, DONG Faming, WANG Wenwen, LI Pengshan, LIANG Liqin. Inhibition Effect of Drug Resistance of Swine Derived Escherichia coli by Combining Traditional Chinese Medicine and Antibacterial Drugs[J]. , 2018, 45(9): 2628-2636.

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Inhibition Effect of Drug Resistance of Swine Derived Escherichia coli by Combining Traditional Chinese Medicine and Antibacterial Drugs

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