抗猫传染性鼻气管炎病毒药物的体外筛选

doi:10.16431/j.cnki.1671-7236.2017.11.039

Abstract

Abstract:

This study was aimed to detect the efficacy of antiviral drugs against feline infectious rhinotracheitis virus. F81 cell was used to construct a model for drug screening against feline infectious rhinotracheitis virus in vitro. Virus inhibition rate was detected with MTT assay and calculated with SPSS software. The IC₅₀ of acyclovir, ribavirin, L-lysine, isatis root and Astragalus polysaccharides were 9.5,3.3,3.4,161.0 and 4.7 μg/mL, respectively,the IC₅₀ of polyinosinic was 6.0 mg/mL. The TI of them were 76.8, 39.3, 2 588.0, 4.5, 78.7 and 5.8, respectively. The effect of L-lysine and Astragalus polysaccharides were most significant.

Key words: feline infectious rhinotracheitis virus; MTT; screening; antiviral drugs

CLC Number:

S859.79⁺2

LIU Jian, YANG Xian-chao, LI Kai-hang, LI Xin, XU Feng, YANG De-quan, GE Jie, JU Hou-bin, ZHOU Jin-ping. Screening of the Drugs Against Feline Infectious Rhinotracheitis Virus in vitro[J]. , 2017, 44(11): 3385-3390.

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Screening of the Drugs Against Feline Infectious Rhinotracheitis Virus in vitro

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