炎症反应致肌肉蛋白质降解机理的研究进展

doi:10.16431/j.cnki.1671-7236.2016.09.024

Abstract

Abstract:

Skeletal muscle wasting is a consequence of the decrease of muscle protein synthesis and/or degradation acceleration,and often accompanies with various serious diseases,such as pathogen infection,injury and tumor.At present,many studies have shown that the systemic inflammation is playing an important role in the process of muscle wasting.Based on the current literature,we present an overview of the molecular and cellular mechanisms that contribute to the inflammation-induced muscle wasting,mainly including the ubiquitin-proteasome pathway (UPP),autophagy-lysosomal pathway (ALP),PI3K/Akt pathway,p38/MAPK pathway and NF-κB pathway,which hope to offer the guidance for the treatment of skeletal muscle wasting.

Key words: skeletal muscle wasting; protein degradation; inflammation

CLC Number:

R392

WANG Sheng-jun, LIU Yan, LIU Yu-lan, WANG Wen-jun, ZHANG Jing. Research Progress on the Mechanisms of Inflammation-induced Muscle Protein Degradation[J]. , 2016, 43(9): 2379-2387.

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Research Progress on the Mechanisms of Inflammation-induced Muscle Protein Degradation

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