›› 2015, Vol. 42 ›› Issue (2): 251-257.doi: 10.16431/j.cnki.1671-7236.2015.02.002

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Comparation of Expression Pattern of Clock Genes in Cashmere Goat Skin

JIA Li-li1,2, JIN Feng1,2, FU Shao-yin1,2, ZHENG Zhu-qing1,2, DU Chen1,2, JI Xiao-yang1,2, WANG Zhi-xin1,2, LI Jin-quan1,2, LIU Shao-qing4, ZHANG Wen-guang1,2,3   

  1. 1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
    2. Key Laboratory of Animal Genetics, Breeding and Reproduction of the Inner Mongol Autonomous Region, Hohhot 010018, China;
    3. Institute of ATCG, Inner Mongol Bio-Information, Hohhot 010020, China;
    4. Breeding Field of Inner Mongolia White Cashmere Goat, Etuokeqi 016100, China
  • Received:2014-08-21 Online:2015-02-20 Published:2015-02-13

Abstract: The purpose of this study was to research expression pattern of clock,tim,per1 and cry1 genes in cashmere goats skin,and to analysis the role of Clock genes as well as relationship of tissue development in cashmere goat skin.Clock genes form a transcription-translation feedback loop,clock gene expression was higher through the growth cycle of skin in cashmere goat,activating per1, cry1 genes transcription-conversion process,which regulated mRNA and protein levels of the core Clock genes with rhythmic expression.The result showed that the expression levels of Clock genes in cashmere goat's skin was:clock >tim >per1 >cry1.The period of anagen in skin hair follicle,rhythmic expression of high-amplitude clock,per1,tim,cry1 appeared at 04:00,08:00,08:00,16:00;The periods of telogen in skin hair follicle,rhythmic expression of high-amplitude clock,per1,tim,cry1 appeared at 08:00,04:00,04:00,16:00.Furthermore,the cry1 and per1 genes expression were activated in the Clock genes positive feedback loop,the tim gene expression was activated in a negative feedback loop.In short,under the regulation of clock,tim,per1 and cry1 feedback loop,which operated cyclical phenomenon of pile.

Key words: goat; clock; tim; cry1; per1; skin; expression pattern

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