应激对妊娠期母体免疫影响的研究进展

›› 2013, Vol. 40 ›› Issue (4): 180-184.

应激对妊娠期母体免疫影响的研究进展

刘雪银¹, 杨青春², 余仲佳¹, 刘冠慧¹, 陈耀星¹, 马保臣², 王子旭¹, 董玉兰¹

1. 中国农业大学动物医学院,北京 100193;
2. 中国牧工商(集团)总公司,北京 100070

收稿日期:2012-09-24 出版日期:2013-04-20 发布日期:2013-04-19
通讯作者: 董玉兰(1977-),女,山东人,硕士生导师,副教授,主要从事神经免疫的研究。E-mail:ylbcdong@cau.edu.cn E-mail:ylbcdong@cau.edu.cn
作者简介:刘雪银(1991-),女,四川人,学士,研究方向:应激免疫。杨青春(1972-),男,山西人,兽医师,研究方向:动物药品开发、动物福利研究以及进出口贸易。刘雪银与杨青春对本文具有同等贡献,并列为第一作者。
基金资助:
国家级大学生创新创业训练计划项目(201210019263、201210019069)。

Research Progress on Effect of Maternal Immunity during Pregnancy in Stress

LIU Xue-yin¹, YANG Qing-chun², YU Zhong-jia¹, LIU Guan-hui¹, CHEN Yao-xing¹, MA Bao-chen², WANG Zi-xu¹, DONG Yu-lan¹

1. College of Veterinary Medicine, China Agricultural University, Beijing 100193,China;
2. China Animal Husbandry Group, Beijing 100070,China

Received:2012-09-24 Online:2013-04-20 Published:2013-04-19

摘要/Abstract

摘要： 随着集约化养殖的发展,环境应激对动物生长发育和繁殖的影响愈来愈严重,尤其是妊娠期母体应激,将诱发母体情绪紧张,影响胎儿发育,甚至导致流产。其作用机制可能是通过激活神经－内分泌－免疫网络,导致母体全身免疫和子宫局部淋巴细胞、NK细胞数量和活性失调,引起妊娠期母体免疫微环境紊乱,引发胚胎免疫排斥,影响胎儿发育、异常,甚至死亡。作者就应激对妊娠的影响及其作用通路,尤其是应激对妊娠期母体免疫的研究进展进行了综述。

关键词: 应激; 妊娠; 免疫

Abstract: Environmental stress on animal growth and reproduction of influence were more and more serious with the development of intensive aquaculture. Pregnancy maternal stress would induce maternal emotional tension, affect fetal development, and even cause abortion. Mechanism of stress influence might be caused maternal immunity and the number and activity of uterus lymphocytes, NK disharmony, and then induced the disorder of maternal immunity through the activation of the nerve-endocrine, immune network, which would initiate the embryonic immune rejection, affect fetal dysplasia and even death. The research progress of stress on pregnancy, and the influences role path, especially stress on maternal immune during pregnancy were summarized.

Key words: stress; pregnancy; immunity

中图分类号:

S852.4

刘雪银, 杨青春, 余仲佳, 刘冠慧, 陈耀星, 马保臣, 王子旭, 董玉兰. 应激对妊娠期母体免疫影响的研究进展[J]. , 2013, 40(4): 180-184.

LIU Xue-yin, YANG Qing-chun, YU Zhong-jia, LIU Guan-hui, CHEN Yao-xing, MA Bao-chen, WANG Zi-xu, DONG Yu-lan. Research Progress on Effect of Maternal Immunity during Pregnancy in Stress[J]. , 2013, 40(4): 180-184.

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