2020年国内外家兔遗传育种与繁殖研究进展

doi:10.16431/j.cnki.1671-7236.2022.01.027

摘要/Abstract

摘要： 家兔是中国传统的畜禽品种，同时也是中国畜牧业的重要组成部分。近年来，随着产业升级，生物技术快速发展，国内外家兔遗传育种取得了较大进展。文章分别从传统育种与分子育种2个方面对2020年国内外家兔遗传育种与繁殖研究进展进行了综述，以期为家兔种质资源利用与保护提供参考。国外在传统育种与分子育种上均作了较多研究，在传统育种上主要针对选择和环境因素对家兔生长及繁殖性能的影响进行研究；在分子育种上对生长及肉质相关基因、繁殖性能相关基因及遗传多样性等方面进行研究。国内开展的家兔遗传育种与繁殖研究数量相较国外更多，研究重点集中于分子育种，包括对皮毛性状、肉质性状及繁殖性能相关基因的研究；传统育种主要包括选择和环境效应对家兔生长与繁殖性能的影响。

关键词: 家兔; 遗传育种; 繁殖

Abstract: The rabbit is the one of Chinese traditional domestic animals, and also is an important part of animal husbandry in China. In recent years, with the industry upgrading, the developing rapidly of biotechnology, great progress has been made in rabbit genetic breeding, both at home and abroad. In this review, the research progress on genetic breeding and reproduction of rabbits in 2020 are reviewed from the traditional breeding, molecular breeding and reproduction of rabbits. For abroad, lots of researches involved in traditional breeding and molecular breeding. Traditional breeding mainly focuses on the effects of selection and environment on the growth and reproductive performance of rabbits. In molecular breeding, the related genes of growth, meat quality and genetic diversity were studied. In China, there are more studies on rabbit genetic breeding and reproduction than abroad, and the research concentrate mainly on molecular breeding, including functional genes related to fur traits, meat quality traits and reproductive performance. In addition to, there are lots of studies on the effects of selection and environmental effects on growth and reproductive performance of rabbits in traditional breeding. This review could provide basis and ideas for the protection, development and utilization of the rabbit.

Key words: rabbit; genetic breeding; reproduction

中图分类号:

S829.1

王源朗, 丁海生, 赵辉玲, 黄冬维. 2020年国内外家兔遗传育种与繁殖研究进展[J]. 中国畜牧兽医, 2022, 49(1): 248-255.

WANG Yuanlang, DING Haisheng, ZHAO Huiling, HUANG Dongwei. Research Progress on Genetic Breeding and Reproduction of Domestic and International Rabbits in 2020[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 248-255.

参考文献

[1] 武拉平.2016-2025中国兔产业发展战略思考[J].中国养兔,2017,1:6. WU L P.Strategic thinking on Chinese rabbit industry development from 2016 to 2025[J].Chinese Journal of Rabbit Farming,2017,1:6.(in Chinese)
[2] 黄冬维,陈胜,程广龙,等.我国种兔业存在的问题及发展对策[J].中国草食动物科学,2013,6:63-66. HUANG D W,CHEN S,CHENG G L,et al.Problems and development countermeasures of rabbit industry in China[J].Chinese Herbivore Science,2013,6:63-66.(in Chinese)
[3] 简文素,徐昌文,文斌,等.川白獭兔毛皮品质研究[J].中国养兔,2018,1:8-10. JIAN W S,XU C W,WEN B,et al.Study on fur quality of Sichuan White Rex rabbits[J].Chinese Journal of Rabbit Farming,2018,1:8-10.(in Chinese)
[4] 赖松家,崔恒敏,杨光友,等.天府黑兔新品系选育研究[J].黑龙江畜牧兽医,2002,10:47-49. LAI S J,CUI H M,YANG G Y,et al.Breeding of a new strain of Tianfu Black rabbits[J].Heilongjiang Animal Science and Veterinary Medicine,2002,10:47-49.(in Chinese)
[5] SULEMAN S,KHAN S A,AZIZ M H.Effect of breed on growth performance and carcass quality attributes of apparently healthy male weanling rabbits under conventional housing system[J].Turkish Journal of Veterinary and Animal Sciences,2020,44(4):945-949.
[6] HOCQUETTE J F,GONDRET F,BAEZA E,et al.Intramuscular fat content in meat-producing animals:Development,genetic and nutritional control,and identification of putative markers[J].Animal an International Journal of Animal Bioscience,2010,4(2):303-319.
[7] KASZA R,DONKO T,MATICS Z,et al.Rabbit lines divergently selected for total body fat content:Correlated responses on growth performance and carcass traits[J].Animals,2020,10(10):1815.
[8] FARGHLY M,MAHROSE K M,MAHMOUD G B,et al.Lighting programs as an appliance to improve growing New Zealand White rabbit's performance[J].International Journal of Biometeorology,2020,64(8):1295-1303.
[9] SECCI G,BOVERA F,MUSCO N,et al.Use of mirrors into free-range areas:Effects on rabbit meat quality and storage stability[J]. Livestock Science,2020,239(1):104094.
[10] FRANK D,JOO S T,WARNER R.Consumer acceptability of intramuscular fat[J].Korean Journal for Food Science of Animal Resources,2016,36(6):699-708.
[11] VAN ELSWYK M E,MCNEILL S H.Impact of grass/forage feeding versus grain finishing on beef nutrients and sensory quality:The US experience[J].Meat Science,2014,96(1):535-540.
[12] MADRID B,VARONA L,BLASCO A,et al.The effect of divergent selection for intramuscular fat on the domestic rabbit genome[J].Animal,2020,14(11):2225-2235.
[13] 董春花.提高家兔产仔数的综合措施[J].中国养兔,2001,6:30-31. DONG C H.Comprehensive measures for raising litter size of rabbits[J].Chinese Journal of Rabbit Farming,2001,6:30-31.(in Chinese)
[14] CASTO-REBOLLO C,ARGENTE M J,GARCIA M,et al.Identification of functional mutations associated with environmental variance of litter size in rabbits[J].Genetics Selection Evolution,2020,52(1):22.
[15] RODRIGUES P,LIMBACK D,MCGINNIS L K,et al.Oogenesis:Prospects and challenges for the future[J].Journal of Cellular Physiology,2008,216(2):355-365.
[16] SERNA-GARCIA M,PEIRO R,SERNA E,et al.Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits[J].Animals,2020,10(10):1924.
[17] VON HOLST D,HUTZELMEYER H,KAETZKE P,et al.Social rank,fecundity and lifetime reproductive success in wild European rabbits (Oryctolagus cuniculus)[J].Behavioral Ecology and Sociobiology,2002,51(3):245-254.
[18] SELTMANN M W,RANGASSAMY M,ZAPKA M,et al.Timing of maternal nest building and perinatal offspring survival in a group-living small mammal[J].Behavioral Ecology and Sociobiology,2017,71(4):64.
[19] HOFFMAN K L,MORALES R I R.Toward an understanding of the neurobiology of "just right" perceptions:Nest building in the female rabbit as a possible model for compulsive behavior and the perception of task completion[J].Behavioural Brain Research, 2009,204(1):182-191.
[20] BENEDEK I,ALTBCKER V,ZSOLNAI A,et al.Exploring the genetic background of the differences in nest-building behavior in European rabbit[J].Animals,2020,10(9):1579.
[21] 王璐,冯慧,冯成利.细胞色素B基因检测方法在物种鉴定中的应用[J].陕西农业科学,2020,66(1):74-76. WANG L,FENG H,FENG C L.Application of cytochrome-B in species indentification[J].Shaanxi Journal of Agricultural Sciences,2020,66(1):74-76.(in Chinese)
[22] EMAM A M,AFONSO S,GONZALEZ-REDONDO P,et al.Status and origin of Egyptian local rabbits in comparison with Spanish common rabbits using mitochondrial DNA sequence analysis[J].World Rabbit Science,2020,28(2):93-102.
[23] 秦应和.家兔育种技术及种业发展[J].饲料与畜牧,2019,371(2):55-59. QIN Y H.Development of rabbit breeding technology and seed industry[J].Feed and Animal Husbandry,2019,371(2):55-59.(in Chinese)
[24] 刘策,孙海涛,白莉雅,等.闽西南黑兔与新西兰白兔的屠宰性能及肉品质研究[J].中国畜牧杂志,2020,57(1):6. LIU C,SUN H T,BAI L Y,et al.A comparative study on slaughter performance and meat quality of Min Southwest Black and New Zealand White rabbits[J].Chinese Journal of Animal Science and Veterinary Medicine,2020,57(1):6.(in Chinese)
[25] 刘福鑫,张英,刘静慧,等.猞猁色獭兔繁殖性能及后代生长性能研究[J].中国养兔,2020,239(5):6-8. LIU F X,ZHANG Y,LIU J H,et al.Study on reproductive performance and offspring growth performance of Lynx Rex rabbits[J].Chinese Journal of Rabbit Farming,2020,239(5):6-8.(in Chinese)
[26] 熊飙,李英姣.品种、出生季节和胎次对家兔繁殖性能的影响[J].中国饲料,2020,16:16-19. XIONG B,LI Y J.Effects of breed,birth season and parity on reproductive performance of rabbits[J].China Feed,2020,16:16-19.(in Chinese)
[27] 郑洁,杨超,雷岷,等.热应激对家兔繁殖性能影响及相关热休克蛋白的研究进展[J].中国养兔,2020,235(1):21-24. ZHENG J,YANG C,LEI M,et al.Research progress on effects of heat stress on reproductive performance of rabbits and related heat shock proteins[J].Chinese Journal of Rabbit Farming, 2020,235(1):21-24.(in Chinese)
[28] GARCIA-ISPIERTO I,PILES M,RAFEL O,et al.High environmental temperature affects fertility in rabbit farms[J]. Reproduction in Domestic Animals,2007,42:128-129.
[29] 陈虹,李国庆,卢葳.热应激对伊拉兔生理常数的影响[J].四川畜牧兽医,2020,47(9):4. CHEN H,LI G Q,LU W.Effects of heat stress on physiological constants of IRA rabbits[J].Sichuan Animal Husbandry and Veterinarian,2020,47(9):4.(in Chinese)
[30] ROY D,ANGELINI N L,FUJIEDA H,et al.Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin[J].Endocrinology,2001,142(11):4711-4720.
[31] 罗刚,孟繁臣,任战军,等.LED光源不同光色与光照强度对母兔繁殖性能的影响[J].家畜生态学报,2020,216(5):57-61. LUO G,MENG F C,REN Z J,et al.Effects of different light color and light intensity of LED light source on reproductive performance of female rabbits[J].Journal of Domestic Animal Ecology,2020,216(5):57-61.(in Chinese)
[32] ANDL T,REDDY S T,GADDAPARA T,et al.WNT signals are required for the initiation of hair follicle development[J].Developmental Cell,2002,2(5):643-653.
[33] BOTCHKAREV V A,SHAROV A A.BMP signaling in the control of skin development and hair follicle growth[J]. Differentiation,2004,72(9-10):512-526.
[34] HAREL S,HIGGINS C A,CERISE J E,et al.Pharmacologic inhibition of JAK-STAT signaling promotes hair growth[J].Science Advances,2015,1(9):e1500973.
[35] WANG L C,LIU Z Y,GAMBARDELLA L,et al.Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration[J].Journal of Investigative Dermatology,2000,114(5):901-908.
[36] LIANG S,BAO Z,ZHAO B,et al.Characterization and functional analysis of Krtap11-1 during hair follicle development in Angora rabbits (Oryctolagus cuniculus)[J].Genes and Genomics,2020,42(11):1281-1290.
[37] ZHOU T,CHEN Y,ZHAO B,et al.Characterization and functional analysis of SIAH1 during skin and hair follicle development in the Angora rabbit (Oryctolagus cuniculus)[J].Hereditas,2020,157(1):10.
[38] ZHAO B,CHEN Y,HU S,et al.Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit[J].Genome,2020,63(5):179-187.
[39] DING H,CHENG G,LENG J,et al.Analysis of histological and microRNA profiles changes in rabbit skin development[J].Scientific Reports,2020,10(1):454.
[40] STURM R A,TEASDALE R D,BOX N F.Human pigmentation genes:Identification,structure and consequences of polymorphic variation[J].Gene,2001,277(1-2):49-62.
[41] YANG N,ZHAO B,HU S,et al.Characterization of POU2F1 gene and its potential impact on the expression of genes involved in fur color formation in Rex rabbit[J].Genes,2020,11(5):575.
[42] HU S,CHEN Y,ZHAO B,et al.KIT is involved in melanocyte proliferation,apoptosis and melanogenesis in the Rex rabbit[J].PeerJ,2020,8(5):e9402.
[43] LI J,CHEN Y,LIU M,et al.Association of melanophilin (MLPH) gene polymorphism with coat colour in Rex rabbits[J]. World Rabbit Science,2020,28(1):29.
[44] 卢婷婷,王曼曼,陈实,等.獭兔MITF不同可变剪接体对黑色素沉积的影响[J].西北农业学报,2020,29(11):1625-1632. LU T T,WANG M M,CHEN S,et al.Effects of MITF variable splice on melanin deposition in Rex rabbits[J].Acta Agriculturae Boreali-occidentalis Sinic, 2020,29(11):1625-1632.(in Chinese)
[45] LIU G,LI S,LIU H,et al.The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits[J].BMC Developmental Biomogy,2020,20(1):8.
[46] FONTANESI L,SCOTTI E,CISAROVA K,et al.A missense mutation in the rabbit melanocortin 4 receptor (MC4R) gene is associated with finisching weight in a meat rabbit line[J].Animal Biotechnology,2013,24(4):268-277.
[47] YANG Z J,FU L,ZHANG G W,et al.Identification and association of SNPs in TBC1D1 gene with growth traits in two rabbit breeds[J].Asian-Australasian Journal of Animal Sciences,2013,26(11):1529-1535.
[48] MIGDAL L,KOZIOL K,PALKA S,et al.Mutations in leptin (LEP) gene are associated with carcass and meat quality traits in crossbreed rabbits[J].Animal Biotechnology,2018,29(2):153-159.
[49] FONTANESI L,SPARACINO G,UTZERI V J,et al.Identification of polymorphisms in the rabbit growth hormone receptor (GHR) gene and association with finishing weight in a commercial meat rabbit line[J].Animal Biotechnology,2016,27(2):77-83.
[50] YANG X,DENG F,WU Z,et al.A genome-wide association study identifying genetic variants associated with growth,carcass and meat quality traits in rabbits[J].Animals,2020,10(6):1068.
[51] LUO G,WANG L,HU S,et al.Association of leptin mRNA expression with meat quality trait in Tianfu Black rabbits[J].Animal Biotechnology,2020,3:1-7.
[52] 李彦宏,罗鑫茂,贾先波,等.天府黑兔APOA4基因多态性及生物信息学分析[J].中国养兔,2020,235(1):10-14. LI Y H,LUO X M,JIA X B,et al.APOA4 gene polymorphism and bioinformatics analysis of Tianfu Black rabbits[J].Chinese Journal of Rabbit Farming,2020,235(1):10-14.(in Chinese)
[53] KORSTANJE R,GILLISSEN G F,VERSTEEG S A,et al.Mapping of rabbit microsatellite markers using chromosome-specific libraries[J].Journal of Heredity,2003,94(2):161-169.
[54] ALLAM M,MAHROUS N S.Molecular genetic diversity of some rabbit breeds based on mitochondrial 16S rRNA sequences[J].World Rabbit Science,2021,29(3):193-201.
[55] MANCIN E,SOSA-MADRID B S,BLASCO A,et al.Genotype imputation to improve the cost-efficiency of genomic selection in rabbits[J].Animals,2021,11(3):803.
[56] 周彤,周娟,梁爽,等.福建黄兔线粒体基因组全序列测定与分析[J].西北农业学报,2020,29(9):9. ZHOU T,ZHOU J,LIANG S,et al.Determination and analysis of complete mitochondrial genome of Fujian Yellow rabbits[J].Acta Agriculturae Boreali-occidentalis Sinic, 2020,29(9):9.(in Chinese)
[57] GARCIA Y,DE LEON R E P,GUZMAN G S.Genetic variation sources influencing fertility and birth traits in F1 rabbits[J].Cuban Journal of Agricultural Science,2008,42(4):333-337.
[58] 牛晓艳,曹亮,李燕平,等.卵泡刺激素(FSHβ)基因多态性及其与獭兔繁殖性状的关联性研究[J].中国养兔,2020,235(1):6-9. NIU X Y,CAO L,LI Y P,et al.Study on follicle stimulating hormone (FSHβ) gene polymorphism and its association with reproductive traits of Rex rabbits[J].Chinese Journal of Rabbit Farming,2020,235(1):6-9.(in Chinese)