›› 2009, Vol. 36 ›› Issue (6): 49-51.

• 生理生化 • 上一篇    下一篇

磷脂氢谷胱苷肽过氧化酶

王茜,张春香,岳文斌, 任有蛇   

  1. (山西农业大学动物科技学院, 太谷 030801)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-06-20 发布日期:2009-06-20
  • 通讯作者: 岳文斌

Phospholipid Hydroperoxide Glutathione Peroxidase

WANG Qian,ZHANG Chun-xiang,YUE Wen-bin,REN You-she   

  1. (Animal Science College of Shanxi Agricultural University, Taigu 030801,China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-06-20 Published:2009-06-20
  • Contact: YUE Wen-bin

摘要: 磷脂氢谷胱苷肽过氧化酶(phospholipid hydroperoxide glutathione peroxidase,PHGPx)是硒谷胱苷肽过氧化酶家族中独特的一员,它不仅具有GPx的抗氧化作用,还具有清除生物膜内及其脂蛋白质上酯脂过氧化物的作用,还是构成精子的结构蛋白,在细胞调亡中也发挥重要作用。作者综述了PHGPx的生物学功能、结构特征、分布、组织表达及分子水平上表达调控的研究进展。

关键词: PHGPx; 生物学功能; 结构特征; 表达调控

Abstract: Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a unique member of the selenium-dependent glutathione peroxidases in mammals with multifunctional function. It acts as a reducing enzyme of peroxidized phospholipids and thiols and as a structural protein; it plays a pivotal role in apoptosis. The progresses of the function, molecular characteristic, tissue expression and regulation of expression were previewed in the article.

Key words: PHGPx; biological function; molecular characteristic; expression regulation

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