›› 2015, Vol. 42 ›› Issue (12): 3246-3252.doi: 10.16431/j.cnki.1671-7236.2015.12.020

• 动物营养与饲料科学 • 上一篇    下一篇

肉鸡日粮中1α-羟基维生素D3与25-羟基维生素D3生物学效价比较研究

韩进诚1, 王建国1,2, 陈冠华1,2, 张金龙1,2, 瞿红侠1, 张进良1, 席丽1, 闫永峰1   

  1. 1. 商丘师范学院生命科学学院, 商丘 476000;
    2. 河南农业大学牧医工程学院, 郑州 450002
  • 收稿日期:2015-06-29 出版日期:2015-12-20 发布日期:2015-12-30
  • 通讯作者: 闫永峰 E-mail:yanyf01@sina.com
  • 作者简介:韩进诚(1977-),男,河北沧州人,副教授,研究方向:家禽营养与饲料科学,E-mail:j.c.han@hotmail.com
  • 基金资助:
    国家自然科学基金项目(31101732);河南省创新型科技人才队伍建设工程项目

Study on Relative Bioavailability of 1α-Hydroxycholecalciferol to 25-Hydroxycholecalciferol in Broiler Chickens

HAN Jin-cheng1, WANG Jian-guo1,2, CHEN Guan-hua1,2, ZHANG Jin-long1,2, QU Hong-xia1, ZHANG Jin-liang1, XI Li1, YAN Yong-feng1   

  1. 1. College of Life Science, Shangqiu Normal University, Shangqiu 476000, China;
    2. College of Animal Husbandry and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
  • Received:2015-06-29 Online:2015-12-20 Published:2015-12-30

摘要: 本试验比较了肉鸡日粮中1α-羟基维生素D3(1α-OH-D3)与25-羟基维生素D3(25-OH-D3)生物学效价。将300只1日龄罗斯308肉鸡公雏随机分为6个处理,每个处理5个重复,每个重复10只鸡。设计6种日粮,即在相同的基础日粮中分别添加2.5、5.0和10.0 μg/kg 25-OH-D3和1.25、2.5和5.0 μg/kg 1α-OH-D3,斜率比法测定1α-OH-D3与25-OH-D3的相对生物学效价。结果显示,日粮中添加1α-OH-D3和25-OH-D3可改善肉鸡平均体增重、料重比及血浆磷浓度,显著增加胫骨和股骨重量、长度和灰分重量(P< 0.05),而对骨骼钙和磷含量无显著影响(P >0.05)。以1~42日龄肉鸡平均体增重、料重比和血浆磷浓度评价,1α-OH-D3生物学效价分别是25-OH-D3的2.16、2.56和2.77倍;以42日龄肉鸡胫骨重量、长度、宽度和灰分重量评价,1α-OH-D3生物学效价是25-OH-D3的1.80、1.88、2.42和2.04倍;以42日龄肉鸡股骨重量、长度和灰分重量评价,1α-OH-D3生物学效价是25-OH-D3的1.89、1.98和2.18倍。试验表明,以1~42日龄肉鸡生长性能和骨骼矿化指标评价,1α-OH-D3生物学效价约为25-OH-D3的2.17倍。

关键词: 1α-羟基维生素D3; 25-羟基维生素D3; 生物学效价; 生长性能; 骨骼矿化; 肉鸡

Abstract: The study was conducted to determine the relative bioavailability (RBV) of 1α-hydroxycholecalciferol (1α-OH-D3) to 25-hydroxycholecalciferol (25-OH-D3) in Ross 308 broiler chickens from 1 to 42 days of age.300 one-day-old Ross 308 broilers were randomly assigned into 6 groups with 5 replicates per group and 10 chicks per replicate.The six groups were fed with basal diets in which 2.5,5.0,10.0 μg/kg 25-OH-D3 and 1.25,2.5,5.0 μg/kg 1α-OH-D3 were added,respectively.The RBV of 1α-OH-D3 to 25-OH-D3 was determined by the slope ratio method.The results showed that average body weight gain (ABWG),feed to gain ratio (F/G),plasma phosphorus (P) were improved with the 1α-OH-D3 and 25-OH-D3 addition and the tibia and femur weight,length,and ash weight were linearly increased with the levels of 1α-OH-D3 or 25-OH-D3 increasing (P< 0.05).Using ABWG,F/G,and plasma P as the criteria,RBV of 1α-OH-D3 to 25-OH-D3 were 2.16,2.56,and 2.77.Using tibia weight,length,width,and ash weight as the criteria,RBV of 1α-OH-D3 to 25-OH-D3 were 1.80,1.88,2.42,and 2.04.Using femur weight,length,and ash weight as the criteria,RBV of 1α-OH-D3 to 25-OH-D3 were 1.89,1.98,and 2.18.These results indicated that the activity of 1α-OH-D3 was approximately 2.17 times higher than that of 25-OH-D3 in promoting growth performance and bone mineralization in broiler chickens from 1 to 42 days of age.

Key words: 1α-OH-D3; 25-OH-D3; bioavailability; growth performance; bone mineralization; broiler chick

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