牛朊蛋白基因多态性对疯牛病影响的研究进展

摘要/Abstract

摘要： 朊蛋白(prion protein,PRNP)是近年来已证明的人和部分哺乳动物传染性海绵状脑病(transmissible spongiform encephalopathy,TSE)的主要根源,该蛋白编码基因的多态性显著影响了人和动物对TSE的易感性或抗病性。牛传染性海绵状脑病俗称"疯牛病"。作者分析了疯牛病的起源、监测和预防措施;简要介绍了牛PRNP基因的结构与功能;系统分析了牛科动物PRNP基因非编码区多态性与抗病性作用;总结了牛科动物PRNP基因启动子区域内23 bp插入/缺失和第1内含子区域内12 bp插入/缺失对疯牛病易感性的影响,为牛的抗病分子育种提供指导。

关键词: 牛脑部海绵状病(BSE); 朊蛋白基因(PRNP); 多态性; 抗性

Abstract: The prion protein is the pathogenesis agent for transmissible spongiform encephlopathies (TSE) of human being and some mammal. The polymorphisms of the prion protein (PRNP)gene were significantly affect the susceptibility or resistance to TSE for human being and mammal. In this paper, we analyzed the origins, the monitoring and prevention of BSE. The structure and function of PRNP gene in cattle were introduced briefly.The polymorphism of bovine PRNP gene locating in non-coding region was analyzed systematically. We also summarized and compared the insertion-deletion (indel) in the promoter (23 bp) and the first intron (12 bp) polymorphism together for BSE susceptibility. These could assist the cattle molecular breeding project.

Key words: bovine spongiform encephalopathies (BSE); prion protein gene (PRNP); polymorphisms; resisitance

中图分类号:

S858.23

陈婷, 刘万洪, 杨春玲, 李强飞, 郝甜甜, 席冬梅. 牛朊蛋白基因多态性对疯牛病影响的研究进展[J]. , 2013, (5): 150-155.

CHEN Ting, LIU Wan-hong, YANG Chun-ling, LI Qiang-fei, HAO Tian-tian, XI Dong-mei. Research Progress on Effect of Polymorphisms of the Prion protein Gene on Bovine Spongiform Encephalopathies[J]. , 2013, (5): 150-155.

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