长链非编码RNA调控牛科反刍动物相关经济性状的研究进展

doi:10.16431/j.cnki.1671-7236.2024.01.021

中国畜牧兽医 ›› 2024, Vol. 51 ›› Issue (1): 203-211.doi: 10.16431/j.cnki.1671-7236.2024.01.021

长链非编码RNA调控牛科反刍动物相关经济性状的研究进展

陈宇¹, 刘俊阳¹, 穆卿¹, 卢泽宇¹, 李蕴华², 刘佳森², 吴子贤^1,2, 王浩源¹, 孙一文¹, 赵艳红¹

1. 内蒙古农业大学动物科学学院, 内蒙古自治区动物遗传育种与繁殖重点实验室, 农业农村部肉羊遗传育种重点实验室, 呼和浩特 010018;
2. 内蒙古自治区农牧业科学院畜牧研究所, 呼和浩特 010031

收稿日期:2023-06-02 出版日期:2024-01-05 发布日期:2023-12-27
通讯作者: 赵艳红 E-mail:13947196432@163.com
作者简介:陈宇,E-mail:1455294571@qq.com。
基金资助:
国家自然科学基金项目（32160772、31860628）；内蒙古自治区科技重大专项（2021ZD0012）；内蒙古自治区研究生科研创新项目（B20210177Z）；内蒙古自治区高等学校创新团队发展计划支持（NMGIRT2322）

Research Progress on the Regulation of Economic Traits Related to Bovine Ruminants by Long-chain Non-coding RNA

CHEN Yu¹, LIU Junyang¹, MU Qing¹, LU Zeyu¹, LI Yunhua², LIU Jiasen², WU Zixian^1,2, WANG Haoyuan¹, SUN Yiwen¹, ZHAO Yanhong¹

1. Key Laboratory of Meat and Sheep Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Inner Mongolia Autonomous Region Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
2. Animal Husbandry Research Institute, Inner Mongolia Autonomous Region Academy of Agriculture and Animal Husbandry Sciences, Hohhot 010031, China

Received:2023-06-02 Online:2024-01-05 Published:2023-12-27

摘要/Abstract

摘要： 长链非编码RNA （long non-coding RNA，lncRNA）是一种长度>200 nt、自身不具有编码能力的真核生物转录本，主要通过转录水平、转录后水平和表观遗传学调控基因的表达，在动植物基因组中普遍存在。lncRNA是一种在动植物生长发育、细胞分化及疾病发生中起着关键作用的调控分子。相较于医疗领域的研究，lncRNA在牛科反刍动物中的研究尚处于起步阶段，特别是调控牛科反刍动物相关经济性状的研究鲜见报道。近年来，高通量测序与微阵列技术的迅速发展，为lncRNA的鉴定提供了更为高效快速的方法。笔者对lncRNA的研究发现、特征分类、转录后水平调控作用机制以及其在牛科反刍动物的肌肉生长、毛囊发育和泌乳性状等方面的研究进行综述，旨在为进一步研究lncRNA在牛科反刍动物生长发育中的调控机制提供理论参考。

关键词: lncRNA; 牛科反刍动物; 生长发育; 经济性状

Abstract: Long non-coding RNA (lncRNA) is a eukaryotic transcript that is longer than 200 nucleotides and does not have the ability to code itself.It regulates the expression of genes mainly through transcriptional level, post-transcriptional level and epigenetics, and is ubiquitous in animal and plant genomes.lncRNA is a regulatory molecule that plays a key role in the growth and development, cell differentiation and disease occurrence of animals and plants.Compared with research in the medical field, the study of lncRNA in bovine ruminants is still in its infancy, especially in the regulation of economic traits related to bovine ruminants.In recent years, the rapid development of high-throughput sequencing and microarray technology has provided more efficient and rapid methods for the identification of lncRNA.Therefore, the author reviews the research findings, feature classification, post-transcriptional horizontal regulation mechanism of lncRNA and their research on muscle growth, hair follicle development and lactation traits in bovine ruminants, which lays a theoretical foundation for further research on the regulatory mechanism of lncRNA in the growth and development of bovine ruminants.

Key words: lncRNA; bovidne ruminants; growth and development; economic traits

中图分类号:

S813.3

陈宇, 刘俊阳, 穆卿, 卢泽宇, 李蕴华, 刘佳森, 吴子贤, 王浩源, 孙一文, 赵艳红. 长链非编码RNA调控牛科反刍动物相关经济性状的研究进展[J]. 中国畜牧兽医, 2024, 51(1): 203-211.

CHEN Yu, LIU Junyang, MU Qing, LU Zeyu, LI Yunhua, LIU Jiasen, WU Zixian, WANG Haoyuan, SUN Yiwen, ZHAO Yanhong. Research Progress on the Regulation of Economic Traits Related to Bovine Ruminants by Long-chain Non-coding RNA[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(1): 203-211.

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长链非编码RNA调控牛科反刍动物相关经济性状的研究进展

Research Progress on the Regulation of Economic Traits Related to Bovine Ruminants by Long-chain Non-coding RNA

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