lncRNA在顶复门原虫感染中的作用机制

doi:10.16431/j.cnki.1671-7236.2022.11.030

中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (11): 4392-4400.doi: 10.16431/j.cnki.1671-7236.2022.11.030

lncRNA在顶复门原虫感染中的作用机制

张亿清^1,2, 李娟¹, 戚南山¹, 廖申权¹, 吕敏娜¹, 林栩慧¹, 蔡海明¹, 胡俊菁¹, 张健騑¹, 李玉谷², 孙铭飞¹

1. 广东省农业科学院动物卫生研究所, 岭南现代农业科学与技术广东省实验室茂名分中心, 广东省畜禽疫病防治研究重点实验室, 农业农村部禽流感等家禽重大疾病防控重点实验室, 广州 510640;
2. 华南农业大学, 广州 510642

收稿日期:2022-05-26 出版日期:2022-11-05 发布日期:2022-11-04
通讯作者: 李玉谷, 孙铭飞 E-mail:liyugu@scau.edu.cn;smf7810@126.com
作者简介:张亿清,E-mail:941331943@qq.com;李娟,E-mail:lijuan84413@163.com。
基金资助:
国家自然科学基金（31872460、31302086）；广东省重点领域研发计划（2020B0202080004）；广东省自然科学基金（2021A1515010521、2021A1515012401）；广东省科技计划项目（2021B1212050021）

Mechanism of lncRNA in Apicomplexan Parasites Infection

ZHANG Yiqing^1,2, LI Juan¹, QI Nanshan¹, LIAO Shenquan¹, LYU Minna¹, LIN Xuhui¹, CAI Haiming¹, HU Junjing¹, ZHANG Jianfei¹, LI Yugu², SUN Mingfei¹

1. Maoming Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Key Laboratory of Avian Influenza and Other Major Poultry Diseases Prevention and Control, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
2. South China Agricultural University, Guangzhou 510642, China

Received:2022-05-26 Online:2022-11-05 Published:2022-11-04

摘要/Abstract

摘要： 长链非编码RNA （long noncoding RNA，lncRNA）是一种核酸长度>200 nt、不编码或具有有限编码能力的RNA，早期一直被认为是遗传暗物质，但伴随分子生物学技术的进步，越来越多的lncRNAs被发掘。研究表明，lncRNA作为基因表达的关键调控因子，能在组蛋白修饰、转录调控和转录后调控等方面影响基因表达，几乎参与所有的细胞生物学过程。顶复门原虫是一类专性胞内寄生虫，入侵机制复杂，对顶复门原虫与宿主的互作研究已成为新型抗虫药物的研发基础。近年来研究发现，lncRNA作为一类新型调控因子广泛参与到顶复门原虫与宿主细胞相互作用中，包括感染免疫、发育分化和信号传导等细胞生物学过程，既可帮助宿主抵御寄生虫入侵，也可协助寄生虫在胞内增殖发育，对疾病的发生发展具有重要的调控作用。笔者通过对lncRNA的生物学分类及其在细胞生理过程中的主要功能进行概述，综合近年来lncRNA在以弓形虫、疟原虫和隐孢子虫为主要代表的顶复门原虫的相关研究，系统梳理了lncRNA在宿主免疫反应、寄生虫发育分化和表观遗传调控等方面的作用机制，以期为顶复门原虫致病机理研究及高效防控技术研发提供新的思路和参考。

关键词: lncRNA; 顶复门原虫; 感染; 互作; 调控

Abstract: Long non-coding RNA (lncRNA) is an RNA with nucleic acid length greater than 200 nt, which does not encode or has limited coding ability.In the early days, it has been considered as genetic dark matter, but with the progress of molecular biology technology, more and more lncRNAs have been discovered.Studies have shown that lncRNA, as a key regulator of gene expression, can affect gene expression in histone modification, transcriptional regulation and post transcriptional regulation, and participate in almost all cell biological processes.Apicomplexan parasite is an obligate intracellular parasite with complex invasion mechanism.The research on the interaction between Apicomplexan parasites and their host has become the basis for the development of new anti-insect drugs.In recent years, it has been found that lncRNA, as a new type of regulatory factor, is widely involved in the interaction between Apicomplexan parasites and host cells, including infection immunity, development and differentiation, signal transduction and other cellular biological processes, which can not only help the host resist the invasion of parasites, but also help the parasites proliferate and develop in the cell, showing an important regulatory role in the occurrence and development of diseases.By summarizing the biological classification of lncRNA and its main functions in cell physiological processes, and combining the relevant studies of lncRNA in Apicomplexan parasites, which is mainly represented by Toxoplasma gondii, Plasmodium and Cryptosporidium in recent years, the author system arranged the mechanism of lncRNA in host immune response, parasite development and differentiation, epigenetic regulation and other aspects, in order to study the pathogenesis of Apicomplexan parasites, and provide new ideas and references for the research and development of efficient prevention and control technology.

Key words: lncRNA; Apicomplexan parasites; infection; interaction; regulation

中图分类号:

S852.72

张亿清, 李娟, 戚南山, 廖申权, 吕敏娜, 林栩慧, 蔡海明, 胡俊菁, 张健騑, 李玉谷, 孙铭飞. lncRNA在顶复门原虫感染中的作用机制[J]. 中国畜牧兽医, 2022, 49(11): 4392-4400.

ZHANG Yiqing, LI Juan, QI Nanshan, LIAO Shenquan, LYU Minna, LIN Xuhui, CAI Haiming, HU Junjing, ZHANG Jianfei, LI Yugu, SUN Mingfei. Mechanism of lncRNA in Apicomplexan Parasites Infection[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4392-4400.

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lncRNA在顶复门原虫感染中的作用机制

Mechanism of lncRNA in Apicomplexan Parasites Infection

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