lncRNA在猪流产相关病毒感染中的作用研究进展

doi:10.16431/j.cnki.1671-7236.2022.09.030

摘要/Abstract

摘要： 猪的繁殖力是决定其生产效率的重要因素，而病毒感染导致的猪流产问题严重影响猪的繁殖效率。了解猪流产相关病毒的致病机制有助于提高猪的繁殖效率，然而大量的研究主要集中在病毒与宿主的蛋白质或基因组DNA上，近年来，长链非编码RNA （long noncoding RNA，lncRNA）从新的视角揭示了病毒与宿主的相互作用，为研究二者之间的互作关系提供了新的途径。lncRNA是一组长度>200 nt的转录本，主要通过与DNA、RNA、染色质和蛋白质互作发挥功能，在某些发育阶段、组织和疾病状态中发生特异性表达，参与机体的多种调控。lncRNA是调控病毒与宿主相互作用的关键因子，在病毒感染宿主后lncRNA发生差异性表达，对应的靶基因富集到炎症和免疫相关的信号通路，参与机体的炎症、免疫和抗病毒反应。深入了解lncRNA在猪流产相关病毒与宿主之间的调控作用，对预防和治疗病毒感染导致的猪流产具有重要意义。作者对lncRNA及其与猪流产相关病毒的关系、宿主lncRNA与病毒的互作及调控通路展开了综述，并对其存在的问题及应用前景进行了展望，以期为猪的抗病育种、猪流产药物的开发和设计及流产类相关疾病的靶点治疗等提供理论依据。

关键词: 长链非编码RNA(lncRNA); 病毒感染; 猪; 流产

Abstract: The reproductive capacity is an important factor to determine the production efficiency of pigs, and the abortion caused by virus infection seriously affects the reproductive efficiency of pigs.Understanding the pathogenic mechanism of porcine abortion-related viruses is helpful to improve the reproductive efficiency of pigs.However, a large number of studies have focused on the protein or genomic DNA of viruses and hosts.In recent years, long noncoding RNA (lncRNA) has revealed the interaction between viruses and hosts from a new perspective, it provides a new way to study the interaction between them.lncRNA is a transcription with a length of more than 200 nt, its function takes mainly through interaction with DNA, RNA, chromatin and protein, and is specifically expressed in certain developmental stages, tissues and disease states, and participates in various regulation of body.lncRNA is a key factor regulating the interaction between virus and host.After virus infects host, lncRNA is differentially expressed, and the corresponding target genes are enriched in inflammatory and immune-related signaling pathways, participating in inflammatory, immune and antiviral responses of body.In-depth understanding of the regulatory role of lncRNA between porcine abortion-related virus and host is of great significance for the prevention and treatment of porcine abortion caused by virus infection.In this paper, lncRNA and its relationship with porcine abortion-related viruses, host lncRNA and virus interaction and regulatory pathways were reviewed, and the existing problems and application prospects were introduced, in order to provide theoretical basis for porcine disease resistance breeding, development and design of porcine abortion-related drugs, and target treatment of abortion-related diseases.

Key words: long noncoding RNA (lncRNA); virus infection; pigs; abortion

中图分类号:

Q527⁺.5

余鹏, 牛晓玉, 董翎, 陆梦琪, 陈燕虹, 李凡, 宋卉. lncRNA在猪流产相关病毒感染中的作用研究进展[J]. 中国畜牧兽医, 2022, 49(9): 3559-3568.

YU Peng, NIU Xiaoyu, DONG Ling, LU Mengqi, CHEN Yanhong, LI Fan, SONG Hui. Research Progress on the Role of lncRNA in Porcine Abortion-related Virus Infection[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3559-3568.

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