ART3功能及其与精子发生关系的研究进展

doi:10.16431/j.cnki.1671-7236.2023.08.019

摘要/Abstract

摘要： ADP核糖基转移酶3(ADP-ribosyl transferases 3,ART3)是ADP核糖基转移酶(ADP-ribosyl transferases,ARTs)家族成员之一,与非阻塞性无精症及癌症高度相关,干扰ART3基因或抑制该基因编码蛋白的表达,会导致精子密度降低、畸形率升高和曲细精管生精细胞脱落。ART3在精子发生过程中不可或缺,因此,深入研究其功能很有必要。目前,ART3在精子发生中的具体作用机制尚不清楚,并且相关研究报道较少。笔者综述了ARTs家族成员蛋白结构及其在精子发生中的作用,ART3蛋白结构预测及其在睾丸组织中的定位,并通过分析其在三阴性乳腺癌和黑色素瘤中的功能和作用,探讨其可能参与的调控通路,以期为揭示ART3在精子发生中的功能及作用机制提供科学参考,为提升动物精液品质、解决雄性不育等问题提供思路。

关键词: ADP-核糖基转移酶(ART3); 精子发生; 亚细胞定位; 精液品质

Abstract: ADP ribosyl transferase 3(ART3) is an ADP-ribosyl transferases,which is highly associated with nonobstructive azoospermia and cancer.Generally,interference with the ART3 gene or inhibition of the protein encoded by the gene results in low sperm density,high malformation rate and the spermatogenic cells in the seminiferous tubules fall off.It shows that ART3 is indispensable in spermatogenesis,and it is necessary to further study its function.At present,the specific roles of ART3 in spermatogenesis is unclear yet and there is very little reports on it.The author reviewed the protein structures of ARTs family members and their roles in spermatogenesis,the results of ART3 protein structure prediction and its localization in testicular tissue,and also summarized the ART3 functions in the pathogenesis of triple negative breast cancer and melanoma and the regulatory pathways in which ART3 had been involved.The review might serve as a scientific reference to help in unveiling the functions of ART3 in spermatogenesis,which might provide insight into the improvement of semen quality and the solutions to male sterility.

Key words: ADP-ribosyl transferase(ART3); spermatogenesis; subcellular localization; semen quality

中图分类号:

S814.4

许师源, 张秋雪, 赵羚均, 董智豪, 刘松奇, 原开敏, 吴开慧, 王栋. ART3功能及其与精子发生关系的研究进展[J]. 中国畜牧兽医, 2023, 50(8): 3221-3228.

XU Shiyuan, ZHANG Qiuxue, ZHAO Lingjun, DONG Zhihao, LIU Songqi, YUAN Kaimin, WU Kaihui, WANG Dong. Research Progress on the Function of ART3 and Its Relationship with Spermatogenesis[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(8): 3221-3228.

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