嗜水气单胞菌群体感应系统及其抑制剂应用研究进展

doi:10.16431/j.cnki.1671-7236.2023.05.026

摘要/Abstract

摘要： 近年来随着抗生素在水产养殖业的滥用,导致细菌耐药性的产生,因此,需要绿色、安全、高效的新型策略来缓解耐药问题。群体感应作为一种通讯机制,根据细菌细胞间的密度来调节其行为和生理反应,其中许多活性物质能通过群体感应系统在不抑制病原菌生长的情况下影响病原菌的致病性,同时减缓耐药的产生。因此,近年来抑制细菌群体感应系统的抑制剂成为研究热点。嗜水气单胞菌作为水产养殖业中的主要条件病原菌,严重危害着水产养殖业的发展。笔者介绍了嗜水气单胞菌群体感应系统的作用机制,对细菌生物被膜的调节,以及群体感应系统抑制剂中草药和益生菌在防控嗜水气单胞菌中的应用,旨在分析嗜水气单胞菌群体感应抑制在未来的发展潜力,为水产养殖业中嗜水气单胞菌的防控提供一定的参考。

关键词: 嗜水气单胞菌; 群体感应; 群体感应抑制剂; 耐药

Abstract: In recent years,with the abuse of antibiotics in aquaculture,bacterial drug resistance has emerged,so green,safe and efficient new strategies are needed to alleviate the drug resistance problem.As a communication mechanism,quorum sensing regulates the behavior and physiological response of bacteria according to the density between cells.Many active substances can affect the pathogenicity of pathogenic bacteria through quorum sensing system without inhibiting the growth of pathogenic bacteria,and at the same time slow down the emergence of drug resistance.Therefore,in recent years,inhibitors that inhibit bacterial quorum sensing system have become a research hotspot.Aeromonas hydrophila,as the main conditional pathogen in aquaculture,seriously harms the economic development of aquaculture.This paper introduced the mechanism of quorum sensing system of Aeromonas hydrophila,the regulation of bacterial biofilm,and the application of quorum sensing system inhibitors of Chinese herbal medicine and probiotics in the prevention and control of Aeromonas hydrophila,aiming at analyzing the development potential of quorum sensing inhibition of Aeromonas hydrophila in the future and providing some reference for the prevention and control of Aeromonas hydrophila in aquaculture.

Key words: Aeromonas hydrophila; quorum sensing; quorum sensing inhibitor; drug resistance

中图分类号:

S852.61

曾成容, 刘馨, 毕文文, 梅世慧, 何广霞, 张俊杰, 文明, 周碧君, 陈江凤, 姜海波. 嗜水气单胞菌群体感应系统及其抑制剂应用研究进展[J]. 中国畜牧兽医, 2023, 50(5): 1991-2000.

ZENG Chengrong, LIU Xin, BI Wenwen, MEI Shihui, HE Guangxia, ZHANG Junjie, WEN Ming, ZHOU Bijun, CHEN Jiangfeng, JIANG Haibo. Research Progress on Quorum Sensing System of Aeromonas hydrophila and Its Inhibitor Application[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1991-2000.

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