益生菌维护肠道健康及抗病毒作用研究进展

doi:10.16431/j.cnki.1671-7236.2022.11.015

摘要/Abstract

摘要： 动物肠道存在复杂的微生物群落，适宜的微环境有利于多种肠道微生物的定植生长。肠道健康是保证动物机体健康的基础，也是当前国内外学者所关注的热点问题。益生菌是对肠道健康有益的微生物，在改善动物肠道健康领域具有极大的潜力。益生菌对病原微生物侵袭有一定的抑制作用，对部分病毒也具有一定的预防及清除作用，但不同菌株作用效果存在较大差异。作者首先将益生菌对肠道健康的保护概括为益生菌抑制病原菌入侵和定植、改善肠道屏障功能、维持肠道健康菌群、提高机体免疫力4种方式，并探讨了不同菌株的作用方式；其次简述了益生菌抗肠道病毒的作用机制，其中，益生菌通过间接方式调节机体免疫是其抗病毒的主要方式；最后讨论了近年来益生菌在轮状病毒、流行性腹泻病毒和传染性胃肠炎病毒中应用的研究进展，并对益生菌的发展前景进行了展望，以期为益生菌在改善动物肠道健康的研究及产品的开发方面提供一定的参考依据。

关键词: 益生菌; 肠道健康; 抗病毒

Abstract: There are complex microbiota in animal intestinal tract, and suitable microenvironment is beneficial to the colonization and growth of gut microbiota.Intestinal health is the basis for ensuring the health of animals, and it is also the current domestic and international research hot spot.As a beneficial microorganism for intestinal health, probiotics have great potential in improving animal intestinal health.Probiotics can inhibit the invasion of pathogenic microorganisms, and have a certain prevention and clearance effect on some viruses, but different strains have different effects.The author firstly summarized four protection modes of probiotics on intestinal health:Inhibiting pathogenic bacteria invasion and colonization, improving intestinal barrier function, maintaining intestinal healthy microbiota and improving immunity, and discussed the action modes of different strains.Secondly, the mechanism of probiotics antiviral was briefly described.Among them, probiotics regulate indirectly immune function is the main way of antiviral.Finally, the research progress on the application of probiotics in Rotavirus, Epidemic diarrhea virus and Infectious gastroenteritis virus in recent years were discussed, and the development prospect of probiotics was prospected, so as to provide certain reference for the research of probiotics in improving animal intestinal health and the development of products.

Key words: probiotics; intestinal health; antiviral

中图分类号:

Q935

赵德辉, 张海华, 王金铭, 马翠柳, 刘晗璐. 益生菌维护肠道健康及抗病毒作用研究进展[J]. 中国畜牧兽医, 2022, 49(11): 4252-4260.

ZHAO Dehui, ZHANG Haihua, WANG Jinming, MA Cuiliu, LIU Hanlu. Research Progress on Maintain Intestinal Health and Antiviral Effect of Probiotics[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4252-4260.

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