脂肪酸功能及其在养猪生产中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2015.12.021

摘要/Abstract

摘要： 脂肪酸是猪饲料中的一种重要营养成分,包括短链脂肪酸、中链脂肪酸和多不饱和脂肪酸等多种类型,它们除了提供能量外还对猪的肠道微生态、机体代谢、免疫机能、繁殖性能等具有调节作用。文章简述了不同饲料原料中脂肪酸的含量、脂肪酸的主要生物学功能及其在养猪生产中的应用效果,以期为养猪生产中合理应用油脂和脂肪酸提供依据。

关键词: 脂肪酸; 功能; 肠道微生态; 机体代谢; 养猪生产

Abstract: Fatty acids are important compositions of nutrient,including short-chain fatty acids,medium-chain fatty acids and polyunsaturated fatty acids.They play a role in optimizing intestinal microflora,modulating nutrient metabolism,improving immunology and reproductive performance of pigs except for providing energy.This paper reviewed fatty acid profile of feed ingredients,basic biological functions of different variety of fatty acids and its application in swine industry to provide evidences for better using lipids and fatty acid in pig diet.

Key words: fatty acid; function; intestinal microflora; body metabolism; pig production

中图分类号:

Q547

宋增廷, 王华朗, 杨荣, 韩垂旺, 蔡仁贤. 脂肪酸功能及其在养猪生产中应用的研究进展[J]. , 2015, 42(12): 3253-3260.

SONG Zeng-ting, WANG Hua-lang, YANG Rong, HAN Chui-wang, CAI Ren-xian. Research Progress on the Function of Fatty Acids and Application in Pig Production[J]. , 2015, 42(12): 3253-3260.

参考文献

[1] 豁银强.短链脂肪酸在猪营养中的研究与应用[J].饲料研究,2011,7:14-15.
[2] 王海燕,李睿.功能性不饱和脂肪酸研究进展[J].肉类研究,2010,12:14-17.
[3] 林华锋,石桂城,何流健.不同油脂的脂肪酸组成比较分析及其在水产中的应用[J].饲料与畜牧,2012,6:30-32.
[4] 王建军,王恬.中链脂肪酸的生物学特性及其在动物生产中的应用[J].动物营养学报,2011,23(7):1073-1078.
[5] 熊本海,庞之洪,罗清尧.中国饲料成分及营养价值表(2013年第24版)(续)[J].中国饲料,2013,22:38-42.
[6] NRC.Nutrient requirements of swine[S].11th.Washington D C:National Academy Press,2012.
[7] 徐俊,苏衍菁,刘明美.脂肪酸在猪日粮中的应用及展望[J].江西饲料,2012,1:4-9.
[8] 阮光锋,范志红,李楠楠,等.烹调对罗非鱼主要营养成分及脂肪酸的影响[J].中国农业大学学报,2012,17(1):143-148.
[9] Hong Y H,Nishimura Y,Hishikawa D,et al.Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43[J].Endocrinology,2005,146(12):5092-5099.
[10] Vidyasagar S,Barmeyer C,Geibel J,et al.Role of short-chain fatty acids in colonic HCO(3) secretion[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2005,288(6):1217-1226.
[11] Comalada M,Bailón E,de Haro O,et al.The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype[J].Journal of Cancer Research and Clinical Oncology,2006,132(8):487-497.
[12] Gantois I,Ducatelle R,Pasmans F,et al.Butyrate specifically down-requlates Salmonella pathogenicity island 1 gene expression[J].Applied and Environmental Microbilology,2006,72(1):946-949.
[13] Van Immerseel F,De Buck J,De Smet I,et al.Interactions of butyric acid-and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro[J].Avian Diseases,2004,48(2):384-391.
[14] Van Immerseel F,Fevez V,De Buck J,et al.Microencapsulated short-chain fatty acids in feed modify colonization and invasion early after infection with Salmonella enteritidis in young chickens[J].Poultry Science,2004,83(1):69-74.
[15] Ganapathy V,Thangaraju M,Prasad P D,et al.Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host[J].Curr Opin Pharmacol,2013,13(6): 869-874.
[16] Vinolo M A,Rodrigues H G Nachbar R T,et al.Reguation of inflammation by shortchain fatty acids[J]. Nutrients,2011,3(10):858-876.
[17] Weber T E,Kerr B J.Butyrate differentially regulates cytokines and proliferation in porcine peripheral blood mononuclear cells[J].Veterinary Immunology and Immunopathology,2006,113(1-2):139-147.
[18] DeCastro M,Nankova B B,Shah P,et al.Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependant signaling pathway[J].Brain Res Mol Brain Rese,2005,142(1):28-38.
[19] Noguchi O,Takeuchi H,Kubota F,et al.Larger diet-induced thermogenesis and less body fat accumulation in rats fed medium-chain triacylglycerols than in those fed long-chain triacylglycerols[J].Journal of Nutritional Science and Vitaminology,2002,48(6):524-529.
[20] Ooyama K,Kojima K,Aoyama T,et al.Decrease of food intake of rats after ingestion of medium-chain tricylglycerol[J].Journal of Nutritional Science and Vitaminology,2009,55(5):423-427.
[21] Messens W,Goris J,Dierick N,et al.Inhibition of Salmonella typhimurium by medium chain fatty acids in an in vitro simulation of the porcine cecum[J].Veterinary Microbiology,2010,141(1-2):73-80.
[22] Skrivanová E,Savka O G,Marouek M.In vitro effect of C2-C18 fatty acids on Salmonellas[J].Folia Microbiol,2004,49(2):199-202.
[23] Kitajka K,Sinclait A J,Weisinger R S,et al.Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(30):10931-10936.
[24] Jump D B.The biochemistry of ω-3 polyunsaturated fatty acids[J].Journal of Biological Chemistry,2002,277:8755-8758.
[25] Kouba M,Enser M,Whittington F M,et al.Effect of a high-linolenic acid diet on lipogenic enzyme activities,fatty acid composition,and meat quality in the growing pig[J].Journal of Animal Science,2003,81(8):1967-1979.
[26] Nuernberg K,Fischer K,Nuernberg G,et al.Effects of dietary olive and linseed oil on lipid composition,meat quality,sensory characteristics and muscle structure in pigs[J].Meat Science,2005,70(1):63-74.
[27] Smith H J,Khal J,Tisdale M J.Downregulation of ubiquitin-dependent protein degradation in murine myotubes during hyperthermia by eicosapentaenoic acid[J].Biochem Biophys Res Commun,2005,332(1):83-88.
[28] Wyke S M,Russell S T,Tisdale M J.Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation[J].Br J Cancer,2004,91(9):1742-1750.
[29] Bergeron K,Julien P,Davis T,et al.Long-chain ω-3 fatty acids enhance neonatal insulin-regulated protein metabolism in piglets by differentially altering muscle lipid composition[J].The Journal of Lipid Research,2007,48:2396-2410.
[30] 罗杰.长链ω-3 UFA对仔猪免疫成熟和生长的影响及调控作用研究[D].武汉:华中农业大学,2009.
[31] Marion-Letellier R,Butler M,Dechelotte P,et al.Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells——Potential for dietary modulation of peroxisome proliferator-activated receptor gamma in intestinal inflammation[J].American Journal of Clinical Nutrition,2008,87(4):939-948.
[32] 李孟伟.ω-3多不饱和脂肪酸免疫调控作用的研究进展[J].湖南饲料,2014,5:26-28.
[33] Castellano C A,Audet I,Bailey J L,et al.Dietary omega-3 fatty acids (fish oils) have limited effects on boar semen stored at 17 ℃ or cryopreserved[J].Theriogenology,2010,74(8):1482-1490.
[34] Spencer J D,Wilson L,Webel S K,et al.Effect of feeding protected n-3 polyunsaturated fatty acids (Fertilium^TM) on liter size in gilts[J].Journal of Animal Science,2004,82(Suppl 1):211.
[35] Webel S K,Otto E R,Webel D M,et al.Effect of protected n-3 polyunsaturated fatty acids on liter size in sows[J].Journal of Animal Science,2003,81(Suppl 1):18.
[36] Sung W K,Mateo R D,Yin Y,et al.Functional amino acids and fatty acids for enhancing production performance of sows and piglets[J].Asian-Australasian Journal of Animal Sciences,2007,20:295-306.
[37] Peng Y,Ren F,Yin J D,et al.Transfer of conjugated linoleic acid from sows to their offspring and its impact on the fatty acid profiles of plasma,muscle,and subcutaneous fat in piglets[J].Journal of Animal Science,2010,88(5):1741-1751.
[38] Muskiet F A J,van Goor S A,Kuipers R S,et al.Long-chain polyunsaturated fatty acids in maternal and infant nutrition[J].Prostaglandins,Leukot Essent Fatty Acids,2006,75(3):135-144.
[39] 吴静.猪营养中的脂肪酸平衡[J].饲料研究,2006,3:39-41.
[40] Yao W,Zhao H L,Li J,et al.Effects of the ratio of n-6:n-3 polyunsaturated fatty acids in the maternal die on immunoglobulins,fatty acid composition,and performance of lactating sows and suckling piglets under conditions of low maternal energy intake[J].Journal of Animal Science and Biotechnology,2012,2(3):141-152.
[41] 左磊,李藏兰,赖长华.不同n-6/n-3多不饱和脂肪酸比值对断奶仔猪生长性能和免疫反应的影响[J].中国畜牧杂志,2010,46(23):48-50.
[42] 纪颖,黄金秀,李藏兰,等.不同n-6/n-3多不饱和脂肪酸比值对LPS诱导的断奶仔猪肠道形态的影响[J].中国畜牧杂志,2011,47(23):39-43.
[43] Lu H,Su S,Ajuwon K M.Butyrate supplementation to gestating sows and piglets induces muscle and adipose tissue oxidative genes and improves growth performance[J].Journal of Animal Science,2012,90:430-432.
[44] Hanczakowska E,Niwinska B,Grela E R,et al.Effect of dietary glutamine,glucose and/or sodium butyrate on piglet growth,intestinal environment,subsequent fattener performance,and meat quality[J].Czech Journal of Animal Science,2014,59(10):460-470.
[45] Wang J,Yang M,Xu S,et al.Comparative effects of sodium butyrate and flavors on feed intake of lactating sows and growth performance of piglets[J].Animal Science Journal,2014,85(6):683-689.
[46] 董冠,杨维仁,杨在宾,等.不同丁酸钠对生长猪生产性能的影响极其比较研究[J].饲料工业,2012,S1:56-58.
[47] 王志刚,章利丰,侯嘉,等.微囊丁酸钠对保育猪生长性能的影响[J].中国饲料,2013,22:29-31.
[48] 陈国顺,余荣,冯光彧.日粮中添加包膜丁酸钠对香猪生产性能和血液生化指标的影响[J].中国畜牧兽医,2012,39(6):98-100.
[49] Fang C L,Sun H,Wu J,et al.Effects of sodium butyrate on growth performance,haemotological and immunological characteristics of weanling piglets[J].Journal of Animal Physiology and Animal Nutrition,2014,98(4):680-685.
[50] Gatlin L A,Odle J,Soede J,et al.Dietary medium-or long-chain trigliycerides improve body condition of lean-genotype sows and increase suckling pig growth[J].Journal of Animal Science,2002,80(1):38-44.
[51] Hong S M,Hwang J H,Kim I H.Effect of medium-chain triglyceride (MCT) on growth performacnce,nutrient digestibility,blood characteristics in weanling pigs[J].Aian-Australasian Journal of Animal Sciences,2012,25(7):1003-1008.
[52] Li Y,Zhang H,Yang L,et al.Effect of medium-chain triglycerides on growth performance,nutrient digestibility,plasma metabolites and antioxidant capacity in weanling pigs[J].Animal Nutrition,2015,1:12-18.
[53] Lai W K,Yen H C,Lin C S,et al.The effects of dietary medium-chain triacylglycerols on growth performance and intestinal microflora in young pigs[J].Journal of Animal and Feed Sciences,2014,23:331-336.
[54] Zentek J,Buchheit-Renko S,Männer K,et al.Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Arch Anim Nutrn,2012,66(1):14-26.
[55] Yen H C,Lai W K,Lin C S,et al.Medium-chain triglyceride as an alternative of in-feed colistin sulfate to improve growth performance and intestinal microbial environment in newly weaned pigs[J].Animal Science Journal,2013,86(1):99-104.
[56] Mohana D S,Kin I H.Effect of medium chain fatty acids (MCFA) and probiotic (Enterococcus faecium) supplementation on the growth performance,digestibility and blood profiles in weanling pigs[J].Veterinarni Medicina,2014,59(11):527-535.
[57] Zentek J,Ferrara F,Pieper R,et al.Effects of dietary combinations of organic acid and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets[J].Journal of Animal Science,2013,91(7):3200-3210.
[58] Hanczakowska E,Szewczyk A,Swiatkiewicz M,et al.Short-and medium-chain fatty acids as a feed supplement for weaning and nursery pigs[J].Polish Journal of Veterinary Sciences,2013,16(4):647-654.
[59] Li Q,Brendemuhl J H,Jeong K C,et al.Effects of dietary omega-3 polyunsaturated fatty acids on growth and immune response of weanling pigs[J].Journal of Animal Science and Technology,2014,56:7-13.
[60] Andersen A D,Ludvig S E,Damsgaard C T,et al.The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2013,89(4):235-240.
[61] Wijendran V,Downs I,Srigley C T,et al.Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2013,89(5):345-350.
[62] de Greeff A,Bikker P,Smit-Heinsbroek A,et al.Increased fat and polyunsaturated fatty acid content in sow gestation diet has no effect on gene expression in progeny during the first 7 days of life[J].Journal of Animal Physiology and Animal Nutrition,2015,Epub ahead of print.
[63] Yao W,Li J,Wang J J,et al.Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins,cytokines,fatty acid composition,and performance of lactating sows and suckling piglets[J].Journal of Animal Science and Biotechnology,2012,3(1):43-50.
[64] Tanghe S,Cox E,Melkebeek V,et al.Effect of fatty acid composition of the sow diet on the innate and adaptive immunity of the piglets after weaning[J].Vet J,2014,200(2):287-293.
[65] Vicente J G,Isabel B,Cordero G,et al.Fatty acid profile of the sow diet alters fat metaolism and fatty acid composition in weaning pigs[J].Animal Feed Science and Technology,2013,181:45-53.
[66] Martínez-Ramírz H R,Kramer J K G,de Lange C F M.Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs[J].Journal of Animal Science,2014,92(1):238-249.
[67] Gjerlaug-Enger E,Haug A,Gaarder M,et al.Pig feeds rich in rapeseed products and organic selenium increased omega-3 fatty acids and selenium in pork meat and backfat[J].Food Sci Nutr,2015,3(2):120-128.
[68] 张飞,柏云爱,鲁海龙.饱和脂肪酸与健康研究进展[J].中国油脂,2012,7(4):29-33.