槲皮素的生理功能及其在鸡生产上的应用

doi:10.16431/j.cnki.1671-7236.2022.06.012

中国畜牧兽医 ›› 2022, Vol. 49 ›› Issue (6): 2116-2128.doi: 10.16431/j.cnki.1671-7236.2022.06.012

槲皮素的生理功能及其在鸡生产上的应用

梅华迪^1,2, 田琦^1,2, 屈圣富^1,2, 高凤仙², 马现永¹, 李贞明¹, 罗雪辉³, 余苗¹

1. 广东省农业科学院动物科学研究所, 农业农村部华南动物营养与饲料重点实验室, 畜禽育种国家重点实验室, 广东省畜禽育种与营养研究重点实验室, 广东省畜禽肉品质量安全控制与评定工程技术研究中心, 广州 510640;
2. 湖南农业大学动物科学技术学院, 长沙 410128;
3. 清远市清城区清远鸡研究院, 清远 511510

收稿日期:2021-10-22 出版日期:2022-06-05 发布日期:2022-05-27
通讯作者: 余苗 E-mail:yumiao@gdaas.cn
作者简介:梅华迪,E-mail:m15973699341@163.com。
基金资助:
国家自然科学基金项目（31902200）；广东省基础与应用基础研究基金项目（2021A1515012120、2019B1515210032）；广东省现代农业产业技术体系饲料创新团队项目（2022KJ115）；广东省农业科学院农业优势产业科学团队建设项目（202118TD）；科技创新战略专项资金（高水平农科院建设）——杰出人才和优秀博士（R2020YC-JC0001、R2020YJ-YB2002）；清远市清城区清远鸡产业园项目（GDSCYY2018-032）

Physiological Function of Quercetin and Its Application in Chickens Production

MEI Huadi^1,2, TIAN Qi^1,2, QU Shengfu^1,2, GAO Fengxian², MA Xianyong¹, LI Zhenming¹, LUO Xuehui³, YU Miao¹

1. Institute of Animal Science, Guangdong Academy of Agricultural Sciences, South China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Livestock and Poultry Breeding and Nutrition, Guangdong Engineering and Technology Research Center for Quality and Safety Control and Evaluation of Livestock and Poultry Meat, Guangzhou 510640, China;
2. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
3. Qingyuan Chickens Research Institute, Qingcheng District, Qingyuan City, Qingyuan 511510, China

Received:2021-10-22 Online:2022-06-05 Published:2022-05-27

摘要/Abstract

摘要： 槲皮素是一种天然的黄酮类有机化合物，其自然资源丰富、安全无毒，具有多种生理功能：如可直接清除细胞内的自由基，激活抗氧化酶系统，抑制氧化应激通路的信号转导，发挥抗氧化功能；可通过抑制炎症通路的激活、降低白细胞活化来限制炎症因子产生，从而起到抗炎功效；可通过抑制肿瘤细胞增殖、迁徙和入侵促进其细胞凋亡，发挥抗肿瘤的作用；还可破坏潜在致病菌菌体细胞壁和细胞膜的结构、阻碍潜在致病菌的蛋白质和核酸合成，竞争菌体内的ATP结合位点等生物膜形成有关的途径，发挥抗菌功能。在鸡生产中，槲皮素可通过增加回肠对营养物质的转运和吸收减少肠道氧化应激引起的损伤，进而改善肉鸡的生长；可通过促进蛋鸡生殖器官发育以及生殖和生长相关激素分泌来提高产蛋性能；可提高鸡蛋和鸡肉品质；调节机体钙、蛋白质和脂代谢；改善机体免疫功能；调控肠道微生物区系。作者就槲皮素抗氧化、抗炎、抗菌等重要生理功能及其作用机制，以及近些年槲皮素在鸡生产中的应用进展进行综述，以期为促进槲皮素在鸡生产上的应用及其在鸡饲料中的开发提供理论依据。

关键词: 槲皮素; 鸡; 生理功能; 作用机制

Abstract: Quercetin is a natural flavonoid organic compound, which is rich in natural resources, safe and non-toxic.Quercetin has many physiological functions:It can directly remove free radicals in cells, activate antioxidant enzyme system, inhibit signal transduction of oxidative stress pathway, and subsequently exert antioxidant function.It can limit the production of inflammatory factors by inhibiting the activation of inflammatory pathways and reducing the activation of white blood cells, and thus achieve the anti-inflammatory effect.It can inhibit the proliferation, migration and invasion of tumor cells, promote their apoptosis and finally play an important role in anti-tumor.It can exert antibacterial function by blocking the ways related to biofilm formation of potential pathogenic bacteria, such as the destruction of the cell wall and cell membrane structure, the synthesis of protein and nucleic acid and the binding of ATP.In the application of chickens production, quercetin can improve the growth of broilers by increasing the transport and absorption of nutrients in ileum and reducing the damage caused by intestinal oxidative stress.It can improve the laying performance by promoting the development of reproductive organs of laying hens and enhancing the secretion of reproductive and growth-related hormones.It can improve the product quality of eggs and chickens, regulate the metabolism of calcium, protein and lipid, improve the immune function of organism, and regulate the intestinal microflora.The authors reviewed the important physiological functions of quercetin, such as antioxidation, anti-inflammation and antibacterial actions and underlying mechanisms, as well as the application progress of quercetin in chickens production in recent years, in order to provide theoretical basis for promoting the application of quercetin in chickens production and the development in chicken feed.

Key words: quercetin; chickens; physiological function; action mechanism

中图分类号:

S816.7

梅华迪, 田琦, 屈圣富, 高凤仙, 马现永, 李贞明, 罗雪辉, 余苗. 槲皮素的生理功能及其在鸡生产上的应用[J]. 中国畜牧兽医, 2022, 49(6): 2116-2128.

MEI Huadi, TIAN Qi, QU Shengfu, GAO Fengxian, MA Xianyong, LI Zhenming, LUO Xuehui, YU Miao. Physiological Function of Quercetin and Its Application in Chickens Production[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2116-2128.

参考文献

[1] NAM J S, SHARMA A R, NGUYEN L T, et al.Application of bioactive quercetin in oncotherapy:From nutrition to nanomedicine[J].Molecules, 2016, 21(1):108.
[2] DOOST A S, KASSOZI V, GROOTAERT C, et al.Self-assembly, functionality, and in-vitro properties of quercetin loaded nanoparticles based on shellac-almond gum biological macromolecules[J].International Journal of Biological Macromolecules, 2019, 129:1024-1033.
[3] 刘淑兰, 翟少伟, 陈龙伟.槲皮素的生理功能及其应用前景[J].广东饲料, 2010, 19(7):25-27. LIU S L, ZHAI S W, CHEN L W.Physiological function and application prospect of quercetin[J].Guangdong Feed, 2010, 19(7):25-27.(in Chinese)
[4] SAEED M, NAVEED M, ARAIN M A, et al.Quercetin:Nutritional and beneficial effects in poultry[J].World's Poultry Science Journal, 2017, 73(2):355-364.
[5] YAHFOUFI N, ALSADI N, JAMBI M, et al.The immunomodulatory and anti-inflammatory role of polyphenols[J].Nutrients, 2018, 10(11):1618.
[6] SAIKI P, NAKAJIMA Y, VAN-GRIENSVEN L J L D, et al.Real-time monitoring of IL-6 and IL-10 reporter expression for anti-inflammation activity in live RAW 264.7 cells[J].Biochemical and Biophysical Research Communications, 2018, 505(3):885-890.
[7] ENDALE M, PARK S C, KIM S, et al.Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells[J].Immunobiology, 2013, 218(12):1452-1467.
[8] GARCÍA-MEDIAVILLA V, CRESPO I, COLLADO P S, et al.The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells[J].European Journal of Pharmacology, 2007, 557(2-3):221-229.
[9] XIONG G, JI W S, WANG F, et al.Quercetin inhibits inflammatory response induced by LPS from porphyromonas gingivalis in human gingival fibroblasts via suppressing NF-κB signaling pathway[J].Biomed Research International, 2019, 2019:6282635.
[10] RICOTE M, LI A C, WILLSON T M, et al.The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation[J].Nature, 1998, 391(6662):79-82.
[11] LIU X Y, YU Z J, HUANG X, et al.Peroxisome proliferator-activated receptor γ (PPARγ) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-κB pathway[J].American Journal of Translational Research, 2016, 8(12):5169.
[12] YANG D W, LIU X Y, LIU M, et al.Protective effects of quercetin and taraxasterol against H₂O₂ induced human umbilical vein endothelial cell injury in vitro[J].Experimental and Therapeutic Medicine, 2015, 10(4):1253-1260.
[13] WANG S N, YAO J Y, ZHOU B, et al.Bacteriostatic effect of quercetin as an antibiotic alternative in vivo and its antibacterial mechanism in vitro[J].Journal of Food Protection, 2018, 81(1):68-78.
[14] 滕楠.槲皮素抑菌作用的体内和体外研究[D].哈尔滨:东北农业大学, 2015. TENG N.Bacteriostasis of quercetin in vivo and in vitro[D].Harbin:Northeast Agricultural University, 2015.(in Chinese)
[15] 洪志伟, 孟令宇, 葛雅琨, 等.槲皮素对大肠杆菌和金黄色葡萄球菌的体外抑菌作用的研究[J].吉林化工学院学报, 2017, 34(5):38-41. HONG Z W, MENG L Y, GE Y K, et al.In vitro bateriostasis of quercetin against Escherichia coli and Staphlococcus aureus[J].Jilin Institute of Chemical Technology, 2017, 34(5):38-41.(in Chinese)
[16] PLAPER A, GOLOB M, HAFNER I, et al.Characterization of quercetin binding site on DNA gyrase[J].Biochemical and Biophysical Research Communications, 2003, 306(2):530-536.
[17] JAISINGHANI R N.Antibacterial properties of quercetin[J].Microbiology Research, 2017, 8(1):13-14.
[18] 陈樱萌, 胡满江, 曾钰鹏, 等.槲皮素对肠道菌群的调节作用研究[J].食品研究与开发, 2020, 41(10):6-15. CHEN Y M, HU M J, ZENG Y P, et al.Study on the regulation of quercetin on intestinal flora[J].Food Research and Development, 2020, 41(10):6-15.(in Chinese)
[19] TAO L H, KRAMER P M, WANG W, et al.Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents[J].Carcinogenesis, 2002, 23(9):1447-1454.
[20] YOSHIZUMI M, TSUCHIYA K, KIRIMA K, et al.Quercetin inhibits Shc-and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin Ⅱ in cultured rat aortic smooth muscle cells[J].Molecular Pharmacology, 2001, 60(4):656-665.
[21] TAN J, WANG B C, ZHU L C.Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin[J].Chemistry & Biodiversity, 2009, 6(7):1101-1110.
[22] NÖTHLINGS U, MURPHY S P, WILKENS L R, et al.A food pattern that is predictive of flavonol intake and risk of pancreatic cancer[J].The American Journal of Clinical Nutrition, 2008, 88(6):1653-1662.
[23] 王箭, 张鹏辉, 涂植光.槲皮素对肺腺癌A549细胞生长的影响[J].第三军医大学学报, 2007, 19:1852-1854. WANG J, ZHANG P H, TU Z G.Effects of quercetin on proliferation of lung cancer cell line A549 by down-regulating hTERT gene expression[J].Journal of Third Military Medical University, 2007, 19:1852-1854.(in Chinese)
[24] LIN C W, HOU W C, SHEN S C, et al.Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells[J].Carcinogenesis, 2008, 29(9):1807-1815.
[25] HUANG Y T, HWANG J J, LEE P P, et al.Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor[J].British Journal of Pharmacology, 1999, 128(5):999-1010.
[26] ENDE C, GEBHARDT R.Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids[J].Planta Medica, 2004, 70(10):1006-1008.
[27] MENDOZA E E, BURD R.Quercetin as a systemic chemopreventative agent:Structural and functional mechanisms[J].Mini Reviews in Medicinal Chemistry, 2011, 11(14):1216-1221.
[28] KOBORI M, TAKAHASHI Y, AKIMOTO Y, et al.Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice[J].Journal of Functional Foods, 2015, 15:551-560.
[29] ADEMOSUN A O, OBOH G, BELLO F, et al.Antioxidative properties and effect of quercetin and its glycosylated form (Rutin) on acetylcholinesterase and butyrylcholinesterase activities[J].Journal of Evidence-Based Complementary & Alternative Medicine, 2016, 21(4):11-17.
[30] QIU L N, LUO Y J, CHEN X J.Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats[J].Biomedicine & Pharmacotherapy, 2018, 103:1585-1591.
[31] ZHANG F W, FENG J, ZHANG J Y, et al.Quercetin modulates AMPK/SIRT1/NFκB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat dietinduced atherosclerosis in the rat carotid artery[J].Experimental and Therapeutic Medicine, 2020, 20(6):280.
[32] HUNG C H, CHAN S H, CHU P M, et al.Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation[J].Molecular Nutrition & Food Research, 2015, 59(10):1905-1917.
[33] ROSENKRANZ S, KNIREL D, DIETRICH H, et al.Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox"[J].The Faseb Journal, 2002, 16(14):1958-1960.
[34] CHEN K C W, ZHOU Y, ZHANG W, et al.Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells[J].Molecular Vision, 2007, 13:374-387.
[35] 朱启航.大蒜素和槲皮素对铅中毒鸡肝脏的保护效应[D].扬州:扬州大学, 2020. ZHU Q H.Protective effects of allicin and quercetin on the liver of lead-poisoned chickens[D].Yangzhou:Yangzhou University, 2020.(in Chinese)
[36] ZHAO Y, HU X B, LIU Y J, et al.ROS signaling under metabolic stress:Cross-talk between AMPK and AKT pathway[J].Molecular Cancer, 2017, 16(1):1-12.
[37] HANIKOGLU A, KUCUKSAYAN E, HANIKOGLU F, et al.Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes[J].Canadian Journal of Physiology and Pharmacology, 2020, 98(3):131-138.
[38] VURUSANER B, POLI G, BASAGA H.Tumor suppressor genes and ROS:Complex networks of interactions[J].Free Radical Biology and Medicine, 2012, 52(1):7-18.
[39] ZHANG S, KIM I H.Effect of quercetin (flavonoid) supplementation on growth performance, meat stability, and immunological response in broiler chickens[J].Livestock Science, 2020, 242:104286.
[40] TORKI M, SCHOKKER D, DUIJSTER-LENSING M, et al.Effect of nutritional interventions with quercetin, oat hulls, β-glucans, lysozyme and fish oil on performance and health status related parameters of broilers chickens[J].British Poultry Science, 2018, 59(5):579-590.
[41] KIM D W, HONG E C, KIM J H, et al.Effects of dietary quercetin on growth performance, blood biochemical parameter, immunoglobulin and blood antioxidant activity in broiler chicks[J].Korean Journal of Poultry Science, 2015, 42(1):33-40.
[42] ABDEL-LATIF M A, ELBESTAWY A R, EL-FAR A H, et al.Quercetin dietary supplementation advances growth performance, gut microbiota, and intestinal mrna expression genes in broiler chickens[J].Animals, 2021, 11(8):2302.
[43] YANG J X, MARIA T C, ZHOU B, et al.Quercetin improves immune function in Arbor Acre broilers through activation of NF-κB signaling pathway[J].Poultry Science, 2020, 99(2):906-913.
[44] 王密.槲皮素调节肉鸡脂质代谢的信号转导机制[D].哈尔滨:东北农业大学, 2020. WANG M.Signal transduction mechanism of quercetin regulating lipid metabolism in broilers[D].Harbin:Northeast Agricultural University, 2020.(in Chinese)
[45] 韩春艳.槲皮素对注射链脲佐菌素AA肉鸡脂质代谢的作用及机制[D].哈尔滨:东北农业大学, 2017. HAN C Y.Effect and mechanism of quercetin on lipid metabolism in AA broilers injected with streptozotocin[D].Harbin:Northeast Agricultural University, 2017.(in Chinese)
[46] MARIA TABASSUM CH.槲皮素对链脲佐菌素诱导的高血糖AA肉鸡的作用及机制[D].哈尔滨:东北农业大学, 2018. MARIA T C.The effect and mechanism of quercetin on hyperglycemic AA broilers induced by streptozotocin[D].Harbin:Northeast Agricultural University, 2018.(in Chinese)
[47] 肖风林.槲皮素对肉鸡回肠禽β-防御素和菌群作用的Toll样受体信号转导机制[D].哈尔滨:东北农业大学, 2020. XIAO F L.Toll-like receptor signal transduction mechanism of quercetin on beta-defensin and microflora in ileum of broilers[D].Harbin:Northeast Agricultural University, 2020.(in Chinese)
[48] GOLIOMYTIS M, TSOUREKI D, SIMITZIS P E, et al.The effects of quercetin dietary supplementation on broiler growth performance, meat quality, and oxidative stability[J].Poultry Science, 2014, 93(8):1957-1962.
[49] 孙丹彤.槲皮素对蛋鸡生产性能、体内和体外抗氧化指标的影响[D].哈尔滨:东北农业大学, 2015. SUN D T.Effects of quercetin on performance and antioxidant status in laying hens in vivo and in vitro[D].Harbin:Northeast Agricultural University, 2015.(in Chinese)
[50] YANG J X, CHAUDHRY M T, YAO J Y, et al.Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens[J].Journal of Animal Physiology and Animal Nutrition, 2018, 102(2):505-513.
[51] 由莹.槲皮素对蛋鸡产蛋性能的雌激素样作用[D].哈尔滨:东北农业大学, 2016. YOU Y.Estrogen-like effect of quercetin on performance in laying hens[D].Harbin:Northeast Agricultural University, 2016.(in Chinese)
[52] 张琳, 李垚, 冯香安, 等.槲皮素对蛋鸡生产性能及脂类代谢的影响[J].中国畜牧兽医, 2013, 40(1):89-93. ZHANG L, LI Y, FENG X A, et al.Effects of quercetin on production performance and lipidsmetabolism of laying hens[J].China Animal Husbandry & Veterinary Medicine, 2013, 40(1):89-93.(in Chinese)
[53] 刘莹.槲皮素对蛋鸡生产性能和蛋品质的影响[D].哈尔滨:东北农业大学, 2013. LIU Y.Effect of quercetin on performance and egg quality in laying hens[D].Harbin:Northeast Agricultural University, 2013.(in Chinese)
[54] 金芳.槲皮素对蛋鸡生产性能及营养物质消化吸收的影响[D].哈尔滨:东北农业大学, 2013. JIN F.Effect of quercetin on performance and related indicators in laying hens at 39 weeks of age[D].Harbin:Northeast Agricultural University, 2013.(in Chinese)
[55] 呼林林.槲皮素对蛋鸡生产性能、蛋品质、胆固醇含量的影响[D].哈尔滨:东北农业大学, 2014. HU L L.Effects of quercetin on performance, egg quality, cholesterol content in laying hens[D].Harbin:Northeast Agricultural University, 2014.(in Chinese)
[56] LIU H N, LIU Y, HU L L, et al.Effects of dietary supplementation of quercetin on performance, egg quality, cecal microflora populations, and antioxidant status in laying hens[J].Poultry Science, 2014, 93(2):347-353.
[57] 金芳, 李垚, 刘红南, 等.槲皮素对39周龄蛋鸡生产性能的影响[J].中国畜牧杂志, 2013, 49(5):62-65. JIN F, LI Y, LIU H N, et al.Effect of quercetin on production performance of 39 weeks laying hens[J].Chinese Journal of Animal Science, 2013, 49(5):62-65.(in Chinese)
[58] 索艳丽.槲皮素对不同时期蛋鸡生产性能和蛋壳品质的影响[D].哈尔滨:东北农业大学, 2013. SUO Y L.Effect of quercetin on performance and eggshell quality of laying hens in different periods[D].Harbin:Northeast Agricultural University, 2013.(in Chinese)
[59] SIMITZIS P, SPANOU D, GLASTRA N, et al.Impact of dietary quercetin on laying hen performance, egg quality and yolk oxidative stability[J].Animal Feed Science and Technology, 2018, 239:27-32.
[60] SKENDER H, YENICE G, DOKUMACIOGLU E, et al.Comparison of the effects of dietary supplementation of flavonoids on laying hen performance, egg quality and egg nutrient profile[J].British Poultry Science, 2017, 58(5):550-556.
[61] 刘红南, 滕楠, 李垚, 等.饲粮添加槲皮素对蛋鸡蛋品质和蛋组分的影响[J].动物营养学报, 2014, 26(8):2246-2252. LIU H N, TENG N, LI Y, et al.Effects of dietary quercetin on egg quality and egg components in laying hens[J].Chinese Journal of Animal Nutrition, 2014, 26(8):2246-2252.(in Chinese)
[62] 索艳丽, 李垚, 刘莹, 等.槲皮素对蛋鸡蛋壳品质的影响[J].中国畜牧兽医, 2013, 40(2):75-79. SUO Y L, LI Y, LIU Y, et al.Effects of quercetin on eggshell quality in laying hens[J].China Animal Husbandry & Veterinary Medicine, 2013, 40(2):75-79.(in Chinese)
[63] 刘莹, 李垚, 索艳丽, 等.槲皮素对蛋鸡产蛋后期蛋品质的影响[J].中国饲料, 2012, 16:17-20. LIU Y, LI Y, SUO Y L, et al.Effects of quercetin on eggs quality of laying hens at late laying stage[J].China Feed, 2012, 16:17-20.(in Chinese)
[64] 李贤, 李敬双, 于洋.洋葱槲皮素对肉鸡肉品质、血液生化及免疫功能的影响[J].饲料研究, 2021, 44(6):45-49. LI X, LI J S, YU Y, et al.Effects of onion quercetin on meat quality, blood biochemistry and immune function of broilers[J].Feed Research, 2021, 44(6):45-49.(in Chinese)
[65] 王盛楠.槲皮素对AA肉鸡蛋白质消化利用的作用及机制[D].哈尔滨:东北农业大学, 2018. WANG S N.Effects and mechanism of quercetin on protein digestion and utilization in AA broilers[D].Harbin:Northeast Agricultural University, 2018.(in Chinese)

槲皮素的生理功能及其在鸡生产上的应用

Physiological Function of Quercetin and Its Application in Chickens Production

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	杜元军, 段国超, 刘玮, 李大鹏, 韩海霞, 雷秋霞, 周艳, 刘杰, 王杰, 曹顶国, 李福伟, 陈甫. 暗斑对蛋鸡蛋品质的影响及其与肠道功能的关系[J]. 中国畜牧兽医, 2023, 50(6): 2305-2311.
[2]	吴立婷, 陆睿, 刘半红, 包红朵, 王永娟, 周艳, 王冉, 张辉. 产气荚膜梭菌噬菌体及乳酸杆菌联用改善肉鸡生长性能和调节肠道菌群功能研究[J]. 中国畜牧兽医, 2023, 50(6): 2321-2332.
[3]	杨庆林, 吴昊, 刘家言, 伏雨欣, 周帅帅, 卢涵, 丁满溢, 李垚. 槲皮素饲料添加剂延长鸡蛋贮存时间的研究[J]. 中国畜牧兽医, 2023, 50(6): 2342-2353.
[4]	卢玉葵, 刘佳琪, 钟嘉诚, 陈济铛, 朱婉君, 张溢珊, 张济培. 鹅源副鸡禽杆菌的分离鉴定及致病性研究[J]. 中国畜牧兽医, 2023, 50(6): 2562-2572.
[5]	片慧芳, 杜旭彬, 李妍, 张雨辰, 刘斐, 虞德兵. 海兰褐壳蛋鸡小黄卵泡颗粒细胞全长转录组测序分析[J]. 中国畜牧兽医, 2023, 50(5): 1754-1763.
[6]	王浩睿, 禹保军, 杨嘉翊, 魏榕, 付希, 王川川, 张迪, 李德生, 蔡正云, 顾亚玲, 张娟. 静原鸡DERA基因生物信息学分析及组织表达研究[J]. 中国畜牧兽医, 2023, 50(5): 1764-1773.
[7]	刘佳隆, 张译文, 张悦然, 孙奇娟, 陈建, 何雷, 贾艳艳, 丁轲, 余祖华. 鸡ELAVL1基因克隆、原核表达及生物信息学分析[J]. 中国畜牧兽医, 2023, 50(5): 1807-1817.
[8]	乔宏兴, 张菡, 赵圣振, 孙彦婷, 张晓静, 康宇, 边传周. 发酵杜仲叶对肉鸡生产性能、抗氧化性能和免疫相关基因表达的影响[J]. 中国畜牧兽医, 2023, 50(5): 1845-1854.
[9]	吴静璇, 孙征, 马雪莲, 张丽阳, 廖秀冬, 罗绪刚, 李素芬, 吕林. 中国畜禽饲料资源中镁含量的调查研究[J]. 中国畜牧兽医, 2023, 50(5): 1888-1898.
[10]	谢华亮, 雷小文, 李建军, 刘珍妮, 钟云平, 谭东海, 张强. 蚯蚓液对105~175日龄蛋鸡产蛋性能、血清生化指标、抗氧化指标及免疫相关指标的影响[J]. 中国畜牧兽医, 2023, 50(5): 1899-1906.
[11]	张金武, 魏紫, 冀禹彤, 吴昌旭, 李振民, 韦英益, 胡庭俊, 于美玲. A型产气荚膜梭菌诱导黄羽肉鸡肠道氧化应激和炎性损伤研究[J]. 中国畜牧兽医, 2023, 50(5): 2069-2081.
[12]	蒋山翊, 周碧君, 文明, 王开功. 中药联合复合益生菌对鸡柔嫩艾美耳球虫的预防作用[J]. 中国畜牧兽医, 2023, 50(5): 2092-2102.
[13]	许丞惠, 张旭梅, 杨彤, 李嘉蕙, 孙亚伟, 史慧君, 付强, 杨莉. 基于网络药理学及分子对接探究益母草碱治疗肠道炎症的分子机制[J]. 中国畜牧兽医, 2023, 50(5): 2103-2113.
[14]	刘歆, 陈群, 邱玉朗, 李林, 侯国喜, 闫晓刚, 李忠和, 陈龙, 高星爱, 柳冬梅, 翟迪, 闫秋良. 鸡粪堆肥含氮和含硫废气产生机制及控制技术研究进展[J]. 中国畜牧兽医, 2023, 50(5): 2166-2174.
[15]	李梦媛, 刘梦潜, 康佳佳, 黄英, 段勇, 贾俊静, 葛长荣, 曹玮娜. 胍基乙酸对肉鸡肉品质和腹脂沉积的影响[J]. 中国畜牧兽医, 2023, 50(4): 1385-1394.