新型猪瘟疫苗的研究进展

doi:10.16431/j.cnki.1671-7236.2018.07.029

Abstract

Abstract:

Classical swine fever is one of the most important infectious diseases that endanger the health of pigs.It has such characteristics as acuteness,heat and high contact,causing great economic losses to the world pig industry.At present,the traditional vaccination is still the main means to prevent classical swine fever.Although traditional vaccines (such as C-strain) play a huge role in the prevention and control of classical swine fever,some shortcomings exist,such as the inability to differentiate between wild-type and vaccinated animals and the immune failure of classical swine fever.Therefore,the development of a new type of vaccine against classical swine fever is of great significance.With the continuous development of molecular biology technology and recombinant DNA technology,the research on genetic engineering vaccines has been continuously deepened.Six kinds of new classical swine fever vaccines such as subunit vaccines,nucleic acid vaccines,recombinant live vaccine vectors,gene deletion vaccines,full-length infectious cDNA marker vaccines and synthetic peptide vaccines have been developed.Compared with the traditional vaccine,the new vaccine is cheap,safe,efficient,easy to transport and save and could distinguish between wild-type virus infection and vaccine immunization.The authors review the research progress of six kinds of new classical swine fever vaccines so as to provide reference for prevention and control of classical swine fever.

Key words: classical swine fever; classical swine fever virus; new-type vaccines

CLC Number:

S858.28

REN Pengju, LI Peng, ZHANG Qiuyu, WANG Yaping, WU Leyi, WANG Xuannian. Research Progress on New Type Classical Swine Fever Vaccines[J]. , 2018, 45(7): 1958-1964.

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Research Progress on New Type Classical Swine Fever Vaccines

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