microRNA在猪中的研究进展

doi:10.16431/j.cnki.1671-7236.2018.06.025

Abstract

Abstract:

microRNA(miRNA) is small non-coding RNAs in eukaryotes that regulates gene expression by combining the 3'end non-coding sequence of target gene,and plays important roles in many biological processes,including cell growth,differentiation,proliferation and apoptosis.miRNA biosynthesis begins in the nucleus,and is divided into three stages of pri-miRNA,pre-miRNA and mature miRNA.The first and second stages are completed in nucleus,and the third stage is completed in cytoplasm.miRNAs have three characteristics,which are widely expressed in eukaryotic cells with length of 21 to 24 nt and highly conserved sequence.The present results indicate that miRNAs involve in porcine embryonic muscle development,postnatal muscle growth and meat quality traits,precursor adipocyte differentiation and lipid deposition,and immune response,interaction between pathogen and swine.Therefore,understanding the functions of miRNA will help to explore the molecular mechanisms of muscle development,fat metabolism,disease immunity in pigs,and may provide references for pig healthy production.

Key words: miRNA; pig; muscle development; fat metabolism; disease and immunity

CLC Number:

Q522

MIAO Zhiguo, ZHANG Jinzhou, ZHANG Xiaojian, WEI Panpeng, GAO Minglei, LIU Yaru. Research Progress on microRNA in Pigs[J]. , 2018, 45(6): 1626-1632.

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Research Progress on microRNA in Pigs

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