Klotho蛋白在动物钙磷代谢调控中的作用

doi:10.16431/j.cnki.1671-7236.2025.06.010

Abstract

Abstract: Calcium and phosphorus are two of the most abundant mineral elements in the animal body and play an important role in various life activities such as growth and development,metabolism,and immune function.Abnormal metabolism of calcium and phosphorus affects animals significantly,and they often cause symptoms of malnutrition and poor performance.Klotho proteins are encoded by the anti-aging gene Klotho and are expressed in kidney,brain,and bone.Klotho proteins have many important functions in biology.It was found that Klotho protein can act as a cofactor binding to fibroblast growth factor receptor (FGFR) to affect ion channel expression and regulate the secretion of hormones related to calcium and phosphorus metabolism to participate in the maintenance of calcium-phosphorus homeostasis in the animal organism.The author reviewed the expression and localization of Klotho protein, its biological functions, as well as the basic processes of calcium and phosphorus metabolism and the possible mechanisms of Klotho protein in regulating calcium and phosphorus metabolism. The paper aimed to provide theoretical references for further in-depth research on the role of Klotho protein in maintaining calcium and phosphorus homeostasis in the body, and for the development and utilization of Klotho protein as a potential target for the treatment of calcium and phosphorus metabolism diseases.

Key words: Klotho protein; calcium and phosphorus metabolism; kidney; bone; calcium regulatory hormone

CLC Number:

S852.21

WU Wenhao, LUAN Xinhong, LIN Shumei, GAI Yedan. Research Progress on the Role of Klotho Protein in the Regulation of Calcium and Phosphorus Metabolism in Animals[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2561-2568.

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Research Progress on the Role of Klotho Protein in the Regulation of Calcium and Phosphorus Metabolism in Animals

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