China Animal Husbandry and Veterinary Medicine ›› 2024, Vol. 51 ›› Issue (2): 649-658.doi: 10.16431/j.cnki.1671-7236.2024.02.021

• Genetics and Breeding • Previous Articles     Next Articles

Research Progress on Bone Morphogenetic Protein Receptor Type-1B Gene in Sheep

YANG Chulei1,2, LI Xingyao1,2, ZHANG Yiyuan1, TANG Hong1, GUO Yanhua1, WANG Limin1,2, ZHOU Ping1,2   

  1. 1. State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural Reclamation Sciences, Shihezi 832000, China;
    2. College of Animal Science and Technology, Shihezi University, Shihezi 832000, China
  • Received:2023-07-04 Online:2024-02-05 Published:2024-01-29
  • Contact: 兵团科技创新人才计划(2021CB032);兵团农业创新工程(NCG202221);
  • Supported by:
    The project was supported by the National Key Research and Development Program of China (2019YFC1905301);National Natural Science Foundation of China (22078115,21776108,21690083,22008078).

Abstract: Sheep reproductive performance holds significant importance in the sheep industry.In addition to various technical methods such as periodic estrus, artificial insemination, and superovulation, among the 20 mutations of 16 genes known to enhance sheep reproductive performance, the bone morphogenetic protein receptor type-1B (BMPR-1B) gene exhibits the most profound impact.BMPR-1B gene stands as the pioneering major lambing gene discovered worldwide.The A746G mutation within the coding region of BMPR-1B gene leads to arginine substitution for glutamine at position 249 in the protein sequence (Q249R), ultimately resulting in increased ovulations and lambs.This paper presents an introduction to the discovery and structure of BMPR-1B gene along with its mutant FecB (A746G).It briefly elucidates on the molecular mechanism of this gene, regulation of BMP/Smad signaling pathway, relationship between sheep reproduction, and provides a concise analysis on how FecB mutation affects ovarian function, follicles, other tissues, hormone regulation and related gene expression in sheep.Further comprehension of BMPR-1B gene will offer valuable insights for researchers exploring regulatory mechanisms inducing increased lambing numbers in sheep and other animals through manipulation of related ligands, regulatory factors as well as upstream and downstream signal proteins.Additionally it can accelerate efficient breeding and reproduction processes among mammals by expanding population size through establishment of multiple litter strains thereby increasing farmers’ economic income.

Key words: bone morphogenetic protein receptor type-1B (BMPR-1B); FecB; sheep

CLC Number: