绵羊骨形态发生蛋白受体-1B基因研究进展

doi:10.16431/j.cnki.1671-7236.2024.02.021

Abstract

Abstract: Sheep reproductive performance holds significant importance in the sheep industry.In addition to various technical methods such as periodic estrus, artificial insemination, and superovulation, among the 20 mutations of 16 genes known to enhance sheep reproductive performance, the bone morphogenetic protein receptor type-1B (BMPR-1B) gene exhibits the most profound impact.BMPR-1B gene stands as the pioneering major lambing gene discovered worldwide.The A746G mutation within the coding region of BMPR-1B gene leads to arginine substitution for glutamine at position 249 in the protein sequence (Q249R), ultimately resulting in increased ovulations and lambs.This paper presents an introduction to the discovery and structure of BMPR-1B gene along with its mutant FecB (A746G).It briefly elucidates on the molecular mechanism of this gene, regulation of BMP/Smad signaling pathway, relationship between sheep reproduction, and provides a concise analysis on how FecB mutation affects ovarian function, follicles, other tissues, hormone regulation and related gene expression in sheep.Further comprehension of BMPR-1B gene will offer valuable insights for researchers exploring regulatory mechanisms inducing increased lambing numbers in sheep and other animals through manipulation of related ligands, regulatory factors as well as upstream and downstream signal proteins.Additionally it can accelerate efficient breeding and reproduction processes among mammals by expanding population size through establishment of multiple litter strains thereby increasing farmers’ economic income.

Key words: bone morphogenetic protein receptor type-1B (BMPR-1B); FecB; sheep

CLC Number:

S813

YANG Chulei, LI Xingyao, ZHANG Yiyuan, TANG Hong, GUO Yanhua, WANG Limin, ZHOU Ping. Research Progress on Bone Morphogenetic Protein Receptor Type-1B Gene in Sheep[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 649-658.

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Research Progress on Bone Morphogenetic Protein Receptor Type-1B Gene in Sheep

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