绵羊重要经济性状可用遗传标记研究进展

doi:10.16431/j.cnki.1671-7236.2023.08.012

Abstract

Abstract: As an important economic animal,sheep is one of the sources of meat,milk and fur in human society.Growth traits,carcass traits,breeding traits,reproductive traits,disease resistance and cold resistance are important economic traits of production and genetic breeding in sheep,understanding the molecular genetic basis of these traits,determining the key functional genes and genetic markers are conducive to improve the accuracy of important economic trait selection,and accelerate the genetic improvement of economic traits in sheep.With the development of genome resequencing,transcriptome sequencing and methylation sequencing,as well as the maturity of genome-wide association analysis technologies,there were many reports on the association analysis of phenotypic traits and genotypes in sheep,and a series of candidate genes and genetic marker related to economic traits in sheep have been excavated.The author summarized the available genetic marker genes screened in recent years mainly from the perspectives of growth and development,reproduction,tail lipid deposition and wool production,and selected some star genes,such as myocyte enhancer factor 2B (MEF2B) and somatostatin receptor 1 (SSTR1) affected body weight in sheep.Vertebrae development associated gene (VRTN) was a major gene that determines the number of thoracic vertebrae.Fecundity booroola (FecB),bone morphogenetic protein 15 (BMP15) and follicle stimulating hormone receptor (FSHR) were related to the breeding characters of sheep.Platelet derived growth factor D (PDGFD) and BMP2 genes were strongly selected in Fat-tailed sheep,and played an important role in tail fat deposition.Signaling protein agouti (ASIP) and melanocortin 1 receptor (MC1R) were significantly associated with hair color in sheep.The mutation sites,base changes and mutation types of available genetic markers affecting economic traits in sheep were summarized in this paper,which provided ideas for the subsequent research on genetic breeding in sheep.

Key words: sheep; candidate gene; whole genome; genetic marker

CLC Number:

S813.3

LI Xiaojie, HAN Jiangang, LIANG Benmeng, YE Shaohui, JIANG Lin, MA Yuehui. Research Advance on Available Genetic Markers for Important Economic Traits in Sheep[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(8): 3142-3156.

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Research Advance on Available Genetic Markers for Important Economic Traits in Sheep

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