ROH及其在绵羊遗传育种中的应用研究进展

doi:10.16431/j.cnki.1671-7236.2023.08.023

Abstract

Abstract: Runs of homozygosity (ROH) is a long homozygosity segment in the genome.ROH of different lengths and individuals are associated with the genetic background of a common ancestor,and the farther of genetic relationship has the shorter ROH fragment.In the process of inbreeding,with the increase of the number of generations,the ROH inherited from the common ancestor of the offspring individuals will be constantly interrupted and rearranged.ROH is subject to a variety of factors such as population inbreeding,population bottleneck,genomic characteristics and artificial selection,etc.,which will leave various imprints on its genome.There is abundant genetic information in ROH fragments,which equip a new tool for studying sheep genome information.In recent years,with the development of high-throughput sequencing technology,researchers use genome ROH to assess inbreeding degrees and population diversity,infer population structure and history,screen and identify important economic trait genes,and carry out individual selection track selection signals.Therefore,the author summarized the generation principle,influencing factors,detection methods and the application of ROH in sheep genetic breeding,so as to accurately formulate the protection strategy of sheep germplasm resources and provide theoretical basis for the application of ROH in sheep genetic breeding.

Key words: runs of homozygosity (ROH); sheep; genetic breeding

CLC Number:

S813

SUN Lixia, LU Zengkui, YUAN Chao, ZHANG Dan, LIU Jianbin. Research Progress of ROH and Its Application in Sheep Genetic Breeding[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(8): 3258-3266.

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Research Progress of ROH and Its Application in Sheep Genetic Breeding

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