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Effect of Molybdenum on the Lipid Peroxidation Injury and Smac Protein Expression of Kidney in Famale Mice

LIN Lin1,2, LI Qin-fan1, WANG Ji-cang2, WANG Hong-wei2, ZHANG Cai2, YANG Zi-jun2   

  1. 1. College of Veterinary Medicine,Northwest Agricultural and Forestry University, Yangling 712100, China;
    2. College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,China
  • Received:2011-11-24 Online:2012-08-20 Published:2012-08-24

Abstract: To investigate the effect of molybdenum on the lipid peroxidation injury and Smac protein expression of kidney in famale mice. Selected sixty 35-day-old female Kunming mice were randomly divided into 3 groups (control group, molybdenum groupⅠ, molybdenum groupⅡ). Three groups were treated with drinking water added with 0, 200, 400 mg/L molybdenum (Mo6+), respectively. On the 90th days of experiment, the SOD activity and MDA contends were measured, the expression of Smac protein were examined immunohistochemically in kidney tissue. The results showed that the SOD activity was lower in molybdenum group Ⅰthan that of the control group(P<0.05), the SOD activity was lower significantly in molybdenum groupⅡthan that of the control group(P<0.01);the MDA contends was higher in molybdenum groupⅡ than that of the control group in kidney tissue(P<0.05); The expression of Smac of renal cortex was higher significantly in molybdenum group than that of the control group (P<0.01). The results indicated that molybdenum may cause renal lipid peroxidation injury and promote expression of Smac protein in kidney tissue.

Key words: moybdenum; kidney; lipid peroxidation injury; Smac protein; mice

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