China Animal Husbandry and Veterinary Medicine ›› 2024, Vol. 51 ›› Issue (2): 770-778.doi: 10.16431/j.cnki.1671-7236.2024.02.033

• Preventive Veterinary Medicine • Previous Articles     Next Articles

Research Progress on Klebsiella pneumoniae from Giant Pandas

ZHAN Tongtong1, WANG Pingfeng3, ZHENG Xiaomei2, WEN Qiqi2, YE Gang2, DENG Linhua3, YOU Yuyan1, HE Ming3, WANG Qian3, LI Caiwu3, LING Shanshan3   

  1. 1. Beijing Key Laboratory of Captive Wildlife Technologies, Beijing Zoo, Beijing 100044, China;
    2. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611134, China;
    3. China Conservation and Research Center for Giant Panda, Chengdu 610051, China
  • Received:2023-07-19 Online:2024-02-05 Published:2024-01-29
  • Contact: 北京动物园管理处圈养野生动物技术北京市重点实验室开放课题资助(ZDK202214)

Abstract: In recent years, the increasing drug resistance of Klebsiella pneumoniae in captive giant pandas, even the emergence of multi-drug resistance, poses a serious threat to the health of giant pandas.Infections with this bacterium may lead to various diseases such as hemorrhagic colitis and urinary tract infections.With the rise in the number of captive giant pandas and the widespread use of antimicrobial drugs, the problem of drug resistance in Klebsiella pneumoniae has become increasingly prominent.Its pathogenic mechanism involves factors such as capsules, lipopolysaccharides, pili, and iron carrier systems, all of which play a role in the colonization and invasion process of the bacterium.From traditional cultivation to modern molecular detection, techniques for pathogenic identification and diagnosis of Klebsiella pneumoniae in giant pandas have become more convenient, rapid, and reliable.However, there is an urgent need to actively engage in antimicrobial drug development, seek new treatment options, and explore alternative treatment methods such as traditional Chinese medicine and plant extracts to inhibit bacterial growth and slow down the development of drug resistance.This article reviewed the research findings on the biological characteristics of Klebsiella pneumoniae in giant pandas, its current drug resistance status, and diagnostic and therapeutic methods, both domestically and internationally.A review and analysis of existing literature provide new insights for further controlling and delaying the emergence of drug-resistant strains and the spread of drug resistance and offers a valuable reference for the prevention and control of Klebsiella pneumoniae in giant pandas.

Key words: giant panda; Klebsiella pneumoniae; drug resistance; drug resistance mechanism; detection

CLC Number: