Abstract: In recent years, the increasing drug resistance of Klebsiella pneumoniae in captive giant pandas, even the emergence of multi-drug resistance, poses a serious threat to the health of giant pandas.Infections with this bacterium may lead to various diseases such as hemorrhagic colitis and urinary tract infections.With the rise in the number of captive giant pandas and the widespread use of antimicrobial drugs, the problem of drug resistance in Klebsiella pneumoniae has become increasingly prominent.Its pathogenic mechanism involves factors such as capsules, lipopolysaccharides, pili, and iron carrier systems, all of which play a role in the colonization and invasion process of the bacterium.From traditional cultivation to modern molecular detection, techniques for pathogenic identification and diagnosis of Klebsiella pneumoniae in giant pandas have become more convenient, rapid, and reliable.However, there is an urgent need to actively engage in antimicrobial drug development, seek new treatment options, and explore alternative treatment methods such as traditional Chinese medicine and plant extracts to inhibit bacterial growth and slow down the development of drug resistance.This article reviewed the research findings on the biological characteristics of Klebsiella pneumoniae in giant pandas, its current drug resistance status, and diagnostic and therapeutic methods, both domestically and internationally.A review and analysis of existing literature provide new insights for further controlling and delaying the emergence of drug-resistant strains and the spread of drug resistance and offers a valuable reference for the prevention and control of Klebsiella pneumoniae in giant pandas.

Key words: giant panda; Klebsiella pneumoniae; drug resistance; drug resistance mechanism; detection