IGF2基因表达调控及其遗传变异在动物生长发育中的研究进展

doi:10.16431/j.cnki.1671-7236.2020.06.024

Abstract

Abstract: Insulin-like growth factor 2(IGF2),one of the insulin-like hormone family,widely involved in many physiological and metabolic processes of the body,which has an important role in cancer,neuroregulation,metabolic disease,osteoporosis,muscle development and lipidosis.IGF2 functions mainly through competitive binding to the IGF1R,IGF2R or IGF2BPs.Base on the IGF2 plays an important role in musle develop and lipidosis,it makes sense to mine molecular markers of IGF2.Furthermore,the internal regulation mechanism of IGF2 in livestock production was further analyzed.It was found that there was a significant correlation between the genetic variation of IGF2 gene and animal development.Genetic variation functions by affecting IGF2 gene imprinting,methylation,transcription factors binding or post-transcriptional regulation due to miRNA targeting binding.Therefore,this paper focused on the research progress of IGF2 gene expression regulation,gene imprinting,and epigenetic regulation about miRNA,in order to provide relevant reference for the study of IGF2 gene in the regulation of animal growth and development,and provide effective clues for molecular breeding in animal husbandry.

Key words: IGF2 gene; growth and development; transcription factor; heritable variation

CLC Number:

S811.3

ZHAO Haidong, WU Mingli, CHEN Pingbo, WEI Yanpei, WANG Shuhui, SUN Xiuzhu. Research Progress of IGF2 Gene Expression Regulation and Its Genetic Variation in Animal Growth and Development[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1844-1852.

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Research Progress of IGF2 Gene Expression Regulation and Its Genetic Variation in Animal Growth and Development

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