羊口疮病毒与宿主互作研究进展

doi:10.16431/j.cnki.1671-7236.2021.05.027

Abstract

Abstract: Orf is a zoonotic infectious disease,which is mainly caused by Orf virus (OrfV) infection.There is currently no specific medicine to treat it.Envelope protein is the main antigenic protein of OrfV.Its mechanism is mainly to create a series of conditions for the virus to invade host cells,while reducing the host's immunity and enhancing the virulence of the virus.When the virus invades the host,the host will produce an antiviral immune response to eliminate virus particles,including specific humoral immunity and non-specific cellular immune response,but mainly non-specific cellular immune response.The host will produce an antiviral immune response to the virus,and the virus will also form an immune evasion mechanism against the host's immune response.This mechanism is used to avoid the capture and removal of virus particles by the host immune cells,which is the proliferation of virus particles in the host,maturity and enhancement of virus virulence have created various conditions.This article summarized the research status of the interaction between OrfV and the host in recent years,expounded the biological function of the envelope protein of OrfV,the antiviral immune response of the host,the immune evasion mechanism of the virus in the host,and the mechanism of OrfV about the pathogenic effects of some other virulence factors,in order to provide a theoretical reference for the study of the pathogenic mechanism of the ovine aphtha virus and vaccine control.

Key words: Orf virus; antiviral immune response; immune escape

CLC Number:

S852.65

ZHANG You, BAO Taotao, XIAN Simei, YANG Qian, LIANG Qian, GU Qinglin. Research Progress on the Interaction Between Orf Virus and Host[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(5): 1755-1761.

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Research Progress on the Interaction Between Orf Virus and Host

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