羊口疮病毒活载体疫苗和生物制剂的研制现状

doi:10.16431/j.cnki.1671-7236.2015.09.042

Abstract

Abstract: Orf virus (ORFV) has special advantages as the live viral vaccination vectors due to its structure of genome, replication characteristics of encoding gene and quick activation of immunoreactions in host and non-host.In addition, ORFV and its coding proteins have huge potential as clinical biological agents for their function as dual immune modulators.Research statuses on recombinant vaccine of ORFV and biological agents were reviewed which would provide the reference for the development and clinical application of vaccination and biological agents.

Key words: Orf virus (ORFV); live vector vaccine; biological agents

CLC Number:

S852.65

ZHANG Kai-zhao, YU Meng, NING Zhang-yong. Research Status on the Development of Live Vector Vaccine and Biological Agents of Orf Virus[J]. , 2015, 42(9): 2499-2505.

References

[1] Gallina L,Scagliarini L,Mcinnes C J,et al.Parapoxvirus in goats:Experimental infection and genomic analysis[J].Vet Res Commun,2008,32(Suppl1):S203-S205.

[2] Mercer A A,Ueda N,Friederichs S M,et al.Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation[J].Virus Res,2006,116(1-2):146-158.

[3] Dal Pozzo F,Andrei G,Holy A,et al.Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures[J].Antimicrob Agents Chemother,2005,49(12):4843-4852.

[4] White K P,Zedek D C,White W L,et al.Orf-induced immunobullous disease:A distinct autoimmune blistering disorder[J].J Am Acad Dermatol,2008,58(1):49-55.

[5] Li W,Hao W,Peng Y,et al.Comparative genomic sequence analysis of Chinese Orf virus strain NA1/11 with other parapoxviruses[J].Arch Virol,2015,160(1):253-266.

[6] Mcguire M J,Johnston S A,Sykes K F.Novel immune-modulator identified by a rapid,functional screen of the parapoxvirus ovis (Orf virus) genome[J].Proteome Sci,2012,10(1):4.

[7] Rziha H,Henkel M,Cottone R,et al.Generation of recombinant parapoxviruses:Non-essential genes suitable for insertion and expression of foreign genes[J].J Biotechnol,2000,83(1-2):137-145.

[8] Rziha H J,Henkel M,Cottone R,et al.Parapoxviruses:Potential alternative vectors for directing the immune response in permissive and non-permissive hosts[J].J Biotechnol,1999,73(2-3):235-242.

[9] Anziliero D,Kreutz L C,Flores E F,et al.Effects of inactivated parapoxvirus ovis on cellular and humoral events of the innate immune response in mice[J].Cell Immunol,2014,289(1-2):36-41.

[10] Fleming S B,Lyttle D J,Sullivan J T,et al.Genomic analysis of a transposition-deletion variant of orf virus reveals a 3.3 kb region of non-essential DNA[J]. J Gen Virol,1995,76 (12):2969-2978.

[11] Meyer H,Sutter G,Mayr A.Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence[J]. J Gen Virol,1991,72(5):1031-1038.

[12] Delhon G,Tulman E R,Afonso C L,et al.Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus[J].J Virol,2004,78(1):168-177.

[13] Ning Z,Peng Y,Hao W,et al.Generation of recombinant Orf virus using an enhanced green fluorescent protein reporter gene as a selectable marker[J].BMC Vet Res,2011,7:80.

[14] Haig D M,Mcinnes C,Deane D,et al.The immune and inflammatory response to Orf virus[J].Comp Immunol Microbiol Infect Dis,1997,20(3):197-204.

[15] Amann R,Rohde J,Wulle U,et al.A new rabies vaccine based on a recombinant ORF virus (parapoxvirus) expressing the rabies virus glycoprotein[J].J Virol,2013,87(3):1618-1630.

[16] Rohde J,Amann R,Rziha H J.New Orf virus (Parapoxvirus) recombinant expressing H5 hemagglutinin protects mice against H5N1 and H1N1 influenza A virus[J]. PLoS One,2013,8(12):e83802.

[17] Voigt H,Merant C,Wienhold D,et al.Efficient priming against classical swine fever with a safe glycoprotein E2 expressing Orf virus recombinant (ORFV VrV-E2)[J].Vaccine,2007,25(31):5915-5926.

[18] Marsland B J,Tisdall D J,Heath D D,et al.Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site[J].Arch Virol,2003,148(3):555-562.

[19] Fischer T,Planz O,Stitz L,et al.Novel recombinant parapoxvirus vectors induce protective humoral and cellular immunity against lethal herpesvirus challenge infection in mice[J].J Virol,2003,77(17):9312-9323.

[20] van Rooij E M,Rijsewijk F A,Moonen-Leusen H W,et al.Comparison of different prime-boost regimes with DNA and recombinant Orf virus based vaccines expressing glycoprotein D of pseudorabies virus in pigs[J].Vaccine,2010,28(7):1808-1813.

[21] Rohde J,Schirrmeier H,Granzow H,et al.A new recombinant Orf virus (ORFV,Parapoxvirus) protects rabbits against lethal infection with rabbit hemorrhagic disease virus (RHDV)[J].Vaccine,2011,29(49):9256-9264.

[22] Henkel M,Planz O,Fischer T,et al.Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant[J].J Virol,2005,79(1):314-325.

[23] Pekmezci D,Pekmezci G Z,Guzel M,et al.Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis[J].Vet Rec,2014,174(22):556.

[24] Proksch A L,Unterer S,Truyen U,et al.Efficacy of the paramunity inducer PIND-ORF in the treatment of canine parvovirus infection[J].Vet J,2014,202(2):340-347.

[25] Imlach W,Mccaughan C A,Mercer A A,et al.Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages[J].J Gen Virol,2002,83(5):1049-1058.

[26] Wise L,Mccaughan C,Tan C K,et al.Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes,but only partially impairs their proliferation[J]. J Gen Virol,2007,88(6):1677-1682.

[27] Wise L M,Stuart G S,Real N C,et al.Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring[J].Wound Repair Regen,2014,22(3):356-367.

[28] Lateef Z,Baird M A,Wise L M,et al.Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model[J]. J Gen Virol,2009,90(6):1477-1482.

[29] Savory L J,Stacker S A,Fleming S B,et al.Viral vascular endothelial growth factor plays a critical role in orf virus infection[J]. J Virol,2000,74(22):10699-10706.

[30] Deane D,Mcinnes C J,Percival A,et al.Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2[J]. J Virol,2000,74(3):1313-1320.

[31] Deane D,Ueda N,Wise L M,et al.Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins[J].J Gen Virol,2009,90(4):970-977.

[32] Friebe A,Siegling A,Friederichs S,et al.Immunomodulatory effects of inactivated Parapoxvirus ovis (ORF virus) on human peripheral immune cells:Induction of cytokine secretion in monocytes and Th1-like cells[J].J Virol,2004,78(17):9400-9411.

[33] Weber O,Siegling A,Friebe A,et al.Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus[J].J Gen Virol,2003,84(7):1843-1852.

[34] Nowatzky J,Knorr A,Hirth-Dietrich C,et al.Inactivated Orf virus (Parapoxvirus ovis) elicits antifibrotic activity in models of liver fibrosis[J].Hepatol Res,2013,43(5):535-546.

[35] Paulsen D,Urban A,Knorr A,et al.Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models[J].PLoS One,2013,8(9):e74605.

[36] Fiebig H H,Siegling A,Volk H D,et al.Inactivated Orf virus (Parapoxvirus ovis) induces antitumoral activity in transplantable tumor models[J].Anticancer Res,2011,31(12):4185-4190.

[37] Rintoul J L,Lemay C G,Tai L H,et al.ORFV:A novel oncolytic and immune stimulating parapoxvirus therapeutic[J].Mol Ther,2012,20(6):1148-1157.

[38] Horohov D W,Breathnach C C,Sturgill T L,et al.In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis[J].Equine Vet J,2008,40(5):468-472.

[39] Ons E,Van Brussel L,Lane S,et al.Efficacy of a Parapoxvirus ovis-based immunomodulator against equine herpesvirus type 1 and Streptococcus equi equi infections in horses[J].Vet Microbiol,2014,173(3-4):232-240.

[40] Anziliero D,Kreutz L C,Flores E F,et al.Effects of inactivated parapoxvirus ovis on cellular and humoral events of the innate immune response in mice[J]. Cell Immunol, 2014,289(1-2):36-41.

Research Status on the Development of Live Vector Vaccine and Biological Agents of Orf Virus

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	LIANG Qian, BAO Taotao, XIAN Simei, YANG Qian, LI Pengfei, GU Qinglin, ZHENG Weihao, DU Peng, QING Chengxin. Establishment of PMA-PCR Method for Detection of Orf Virus [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1524-1531.
[2]	PANG Feng, LONG Qinqin, LIANG Shaobo, CHENG Hongsong, CHENG Zhentao. Bioinformatics Analysis,Eukaryotic Expression and Subcellular Localization of Orf Virus ORFV114 Protein [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4150-4158.
[3]	YANG Mingzhu, CHEN Xiaochun, SONG Jiacheng, HOU Yaxin, LI Junping. Research Progress on Construction and Application of Recombinant Animal Herpesvirus Live Vector Vaccine [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 338-351.
[4]	DING Xuedong, WANG Guohua, PAN Xiangchen, LIU Dongdong, LUO Xuedong, MA Yuan, LI Maolin, CUI Qi, ZHANG Qijin. Comparison Analysis of Immune Related Gene of Orf Virus in Sheep and Camels [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(12): 3815-3824.
[5]	LI Pengfei, ZHANG You, XIAN Simei, LI Ting, BAO Ximing, ZHANG Yi, RAO Tiyu, WU Bomei. Isolation and Identification of Orf Virus DZ Strain [J]. China Animal Husbandry and Veterinary Medicine, 2019, 46(12): 3725-3732.
[6]	FENG Qian, WU Jinyan, CHEN Yan, LIU Yongjie, ZHANG Keshan, SHANG Youjun, LIU Xiangtao. Comparative Analysis of VIL-10 Gene Between the Vaccine and Wild Strains of Orf Virus [J]. , 2018, 45(9): 2368-2376.
[7]	SUN Zhengnan, MAO Congjian, ZHANG Huanrong. Molecular Characteristics Analysis and Antigen Epitope Prediction of F1L Gene of Orf Virus Isolate from Sichuan [J]. , 2018, 45(7): 1942-1948.
[8]	GE Shikun, ZHANG Kaizhao, LU Rong, LIU Jianxin, NING Zhangyong. Genetic and Phylogenetic Analysis of Orf Virus Isolated in China from 2006 to 2016 [J]. , 2018, 45(2): 439-447.
[9]	YANG Yu, FENG Jie, LIU Ai, ZHANG Su-hui, XU Guo-yang, FENG Jiang, LIU Zong-sheng, XIAN Si-mei. Isolation and Identification of Orf Virus in Chongqing Area, and Prokaryotic Expression of F1L Gene [J]. , 2015, 42(6): 1396-1401.
[10]	LIU Ai, YANG Yu, XIAN Si-mei, LIU Zong-sheng, WU Jian, LUO Bo, CHEN Yong-cui. Cloning and Bioinformatic Analysis of F1L Gene of Orf Virus from Guizhou Province [J]. , 2015, 42(1): 53-60.