Abstract: In order to study the subchronic toxicity of the Jizhikang oral liquid, the test was conducted in accordance with the animal drug technological specification compile of Ministry of Agriculture. Experiment mice were divided into 4 groups, the 3 experiment groups were given Jizhikang oral liquid of 0.01,0.02,0.04 mL/(g·BW) for 28 days. The control group was given the same amount of naomal saline. The results showed that the body weight, organ coefficient, index of hematology and blood biochemistry indices in 3 experiment groups were not significantly different from that in the control group(P>0.05). Results of histopathology examination showed that it had no adverse reaction in experiment groups. The results showed that the Jizhikang oral liquid had no subchronic toxicity,and could be safely used for experimental animals.

Key words: Jizhikang oral liquid; mice; subchronic toxicity test