生长激素激活受体机理的研究进展

Abstract

Abstract: The growth hormone (GH),a 191 amino acid polypeptide secreted by the anterior pituitary into the blood circulation,has a molecular weight of 22 ku. It binds to membrane receptors existing as a preformed dimer in target tissues to cause a conformational change to exert on its effects. Janus kinase 2 (JAK2) and other cytokines are rapidly activated after GH binding and induced four different signal transduction pathways which bring signal into cells to generate a series of physiological effects such as metabolism,proliferation and differentiation. This article reviewed the structure,mechanism of action,and signal transduction pathways of growth hormone and growth hormone receptor.

Key words: growth hormone; growth hormone receptor; mechanism of action; signal transduction

CLC Number:

Q257

YANG Yan-hong, FU Zhi-ling, LAN Hai-nan, LI Wei, LIU Yu, GUO Feng, ZHANG Hui, CUI Huan-zhong, ZHAO Xue, ZHENG Xin. Research Progress on the Mechanism of Growth Hormone-activated Receptor[J]. , 2013, 40(10): 148-151.

References

1 马晓,胡毅,熊钢,等.生长激素受体及其基因研究进展[J].湖南农业大学学报,2010,36(1):58~62.
2 张明哲,叶丹,张志和,等.生长激素受体及其介导的信号转导[J].细胞生物学杂志,2005,27:49~52.
3 陈宝定,李琦华,李丽红,等.生长激素与生长激素受体基因的表达[J].中国畜牧兽医,2007,34(11):52~54.
4 贺淹才.生长激素和生长激素受体的分子生物学[J].生命的化学,2002,22(1):29~32.
5 Barclay J L,Kerr L M,Arthur L.In vivo targeting of the GH receptor box1 sequence demonstrates that GHR does not signal exclusively through JAK2[J]. Mol Endocrinol,2010,24:204~217.
6 Baumann G P.Growth hormone isoforms[J].Growth Hormone & IGF Reasearch,2009,19:333~340.
7 Birzniece V,Sata A,Ho K K. Growth hormone receptor modulators[J]. Rev Endocr Metab Disord,2009,10:145~156.
8 Brooks A J,Wooh J W,Tunny K A,et al. Growth hormone receptor; mechanism of action[J]. The International Journal of Biochemistry & Cell Biology, 2008,40:1984~1989.
9 Brown R J,Adams J J,Pelekanos R A,et al. A model for GH receptor activation based on subunit rotation within a receptor dimer[J].Nature Structural & Molecular Biology,2005,12:814~821.
10 Conway-Campbell B L,Brooks A J,Robinson P J,et al. The extracellular domain of the growth hormone receptor intracts with coactivator to promote cell proliferation[J]. Mol Endocrinol,2008,22(9):2190~2202.
11 De Vos A M,Ultsch M,Kossiakoff A A. Human growth hormone and extracellular domain of its receptor:Crystal structure of the complex[J].Science,1992,255:306~312.
12 Fuh G,Cunningham B C,Fukunaga R,et al. Rational design of potent antagonists to the human growth hormone receptor[J]. Science,1992,256:1677~1680.
13 Gent J,van Kerkhof P,Roza M,et al.Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis[J]. PNAS,2002,99:9858~9863.
14 Highham C E,Trainer P J. Growth hormone excess and the development of growth hormone receptor antagnists[J].Experlmental Physlogy,1993,11:1157~1169.
15 Kaabi Y A.Growth hormone and its receptor:A molecular insight[J]. Saudi Journal for Health Sciences,2012,1:61~68.
16 Leung D W,Spencer S A,Cachianes G, et al.Growth hormone receptor and serum binding protein:Purification,cloning and expression[J]. Nature, 1987, 330: 537~543.
17 Pang X,Zhou H X.A common model for cytokine receptor activation:Combined scissor-like rotation and self-rotation of receptor dimer induced by class Ⅰ cytokine[J]. PLoS Comput Biol,2012,8:e1002427.
18 Rowlinson S W,Behncken S N,Rowland J E,et al. Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling[J].Biological Chemistry,1998,273:5307~5314.
19 Smith S O,Song D,Shekar S,et al.Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers[J].Biochemistry,2001,40:6553~6558.
20 Tripathi A,Sodhi A. Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: Role of JAK/STAT,PI3K,PKC and MAP kinases[J]. Immunobiology,2009,214:430~440.
21 Wan Y,Zheng Y Z,Harris J M,et al.Epitope map for growth hormone receptor agonist monoclonal antibody,MAb263[J]. Molecular Endocrinology,2003,17(11):2240~2250.
22 Waters M J,Hoang H N,Fairlie D P,et al. New insights into growth hormone action[J]. Molecular Endocrinology,2006,36:1~7.
23 Waters M J,Brooks A J. Growth hormone receptor: Structure function relationships[J]. Horm Res Paediatr, 2011,76:12~16.

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Research Progress on the Mechanism of Growth Hormone-activated Receptor

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