Abstract: The pathogen were isolated and identified on feces of sick piglets and disease of the spleen, liver, lymph nodes, lung, kidney edema fluidin a pig farm in Hunan northwestern region. Susceptibility of 15 kinds antimicrobial drug was determined with the Kirby-Barer for isolated strains. The results showed piglets were infected with E. coli-based and Staphylococcus. Escherichia coli was sensitive to gentamicin, cephalosporins latter skin, Amikacin, tetracycline, cefoperazone sodium, to chloramphenicol, piperacillin, pioneer V, ceftriaxone, neomycin was intermediate, to carbenicillin, doxycycline, penicillin, ampicillin, erythromycin had a higher resistance. Staphylococcus was sensitive to pioneer V, Amikacin, to ceftriaxone was intermediate, on the other antibiotic was resistance. Which was 33.33% the rate of drug sensitivity, intermediate and resistance to E.coli. Which was 13.33% sensitive rate, intermediate rate was 6.67%, resistance rate was 80.00% to Staphylococcus.

Key words: pig; Escherichia coli; Staphylococcus; drug susceptibility testing