›› 2012, Vol. 39 ›› Issue (7): 159-162.

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Artificial Design Cecropins of AMP-D and Determination of Activity

HAN Jin-hui1, ZHAI Pei1, SHI Yong-hui2   

  1. 1. Guangdong Food and Drug Vocational College, Guangzhou 510520,China;
    2. Jiangnan University,Wuxi 214122,China
  • Received:2012-05-18 Online:2012-07-20 Published:2012-07-16

Abstract: By the experiment of antimicrobial peptides structure optimization and solid-phase synthesis technology of synthetic,new antibacterial peptide AMP-D could be obtained. According to determination of its activity and hemolytic, the experimental results showed that AMP-D could inhibit the growth of Gram-positive bacteria, and was no hemolytic activity. Minimal inhibitory concentration of AMP-D was 10.5 μg/mL against Staphylococcus aurous. The antimicrobial activities of AMP-D had more improve than the original peptide.

Key words: cecropin; AMP-D; antibacterial activity; hemolytic

CLC Number: